Neurofibroma laboratory findings: Difference between revisions

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Latest revision as of 21:48, 28 April 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

On Immunohistochemistry, neurofibroma stains positive for S100, SOX10, CD34, factor XIIIa, neurofilament, GFAP and calretinin and negative for EMA, keratin, smooth muscle actin, desmin, calponin, caldesmon and p53.

Laboratory Findings

Immunohistochemistry of neurofibroma is as follows:

Positive for:
- S100
- SOX10
- CD34 (focal)
- Factor XIIIa (focal)
- Neurofilament (and Bielshowsky)
- GFAP
- Calretinin (focal)
Negative for:
- EMA (except in plexiform neurofibromas)
- Keratin
- Smooth muscle actin
- Desmin
- Calponin
- Caldesmon
- P53

Immunohistochemical differences between Neurofibroma and Schwannoma
Immunohistochemical stain	Neurofibroma	Schwannoma
S-100 and SOX10	Moderate positivity	Strong, diffuse positivity
CD34	Moderate	Scattered cells in Antoni B areas
Neurofilament (and Bielshowsky)	Stains entrapped axons within lesion	Stains peripherally located axons of parent nerve
Factor XIIIa	Moderate	Negative to focal
Calretinin	Negative to focal	Moderate
GFAP	Variable, weak	Variable, moderate

References

Template:WikiDoc Sources

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Neurofibroma}}
-{{CMG}}; {{AE}} {{SC}}
+{{CMG}}; {{AE}}{{S.M.}}
 ==Overview==
-There are no laboratory findings associated with neurofibroma.
+On [[Immunohistochemistry]], [[neurofibroma]] [[Stain|stains]] positive for [[S100A1|S100]], [[SOX10]], [[CD34]], factor XIIIa, [[neurofilament]], [[GFAP]] and [[calretinin]] and negative for EMA, [[keratin]], [[smooth muscle]] [[actin]], [[desmin]], [[calponin]], [[caldesmon]] and [[p53]].
 ==Laboratory Findings==
-There are no laboratory findings associated with neurofibroma.
+[[Immunohistochemistry]] of [[neurofibroma]] is as follows:
+*Positive for:
+**[[S100A1|S100]]
+**[[SOX10]]
+**[[CD34]] (focal)
+**Factor XIIIa (focal)
+**[[Neurofilament]] (and Bielshowsky)
+**[[GFAP]]
+**[[Calretinin]] (focal)
+*Negative for:
+**EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]])
+**[[Keratin]]
+**[[Smooth muscle]] [[actin]]
+**[[Desmin]]
+**[[Calponin]]
+**[[Caldesmon]]
+**[[P53]]
+{| class="wikitable"
+|+Immunohistochemical differences between Neurofibroma and Schwannoma
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Immunohistochemical stain
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Neurofibroma
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Schwannoma
+|-
+| style="background:#DCDCDC;" align="center" + |'''[[S-100]] and [[SOX10]]'''
+|Moderate [[Positivity effect|positivity]]
+|[[Strong]], [[diffuse]] [[Positivity effect|positivity]]
+|-
+| style="background:#DCDCDC;" align="center" + |'''[[CD34]]'''
+|Moderate
+|Scattered [[Cells (biology)|cells]] in Antoni B [[Area|areas]]
+|-
+| style="background:#DCDCDC;" align="center" + |'''[[Neurofilament]] (and Bielshowsky)'''
+|[[Stain|Stains]] entrapped [[axons]] within [[lesion]]
+|[[Stain|Stains]] peripherally located [[axons]] of parent [[nerve]]
+|-
+| style="background:#DCDCDC;" align="center" + |'''Factor XIIIa'''
+|Moderate
+|Negative to focal
+|-
+| style="background:#DCDCDC;" align="center" + |'''[[Calretinin]]'''
+|Negative to focal
+|Moderate
+|-
+| style="background:#DCDCDC;" align="center" + |'''[[GFAP]]'''
+|Variable, weak
+|[[Variable|Variable,]] moderate
+|}
 ==References==
@@ Line 17: / Line 63: @@
 {{WikiDoc Help Menu}}
 {{WikiDoc Sources}}
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Neurology]]
+[[Category:Neurosurgery]]

Neurofibroma laboratory findings: Difference between revisions

Latest revision as of 21:48, 28 April 2019

Overview

Laboratory Findings

References

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