Neurofibroma laboratory findings: Difference between revisions

Jump to navigation Jump to search
← Older edit
VisualWikitext
 
(5 intermediate revisions by 2 users not shown)
Line 3: Line 3:
{{CMG}}; {{AE}}{{S.M.}}
{{CMG}}; {{AE}}{{S.M.}}
==Overview==
==Overview==
[[Immunohistochemistry]] of [[neurofibroma]] shows [[Positivity effect|positivity]] for [[S100A1|S100]], [[CD34]], and factor XIIIa and [[Negativity bias|negativity]] for EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]]).
On [[Immunohistochemistry]], [[neurofibroma]] [[Stain|stains]] positive for [[S100A1|S100]], [[SOX10]], [[CD34]], factor XIIIa, [[neurofilament]], [[GFAP]] and [[calretinin]] and negative for EMA, [[keratin]], [[smooth muscle]] [[actin]], [[desmin]], [[calponin]], [[caldesmon]] and [[p53]].


==Laboratory Findings==
==Laboratory Findings==
Line 9: Line 9:
*Positive for:
*Positive for:
**[[S100A1|S100]]
**[[S100A1|S100]]
**Sox10
**[[SOX10]]
**[[CD34]] (focal)
**[[CD34]] (focal)
**Factor XIIIa (focal)
**Factor XIIIa (focal)
**Neurofilament (and Bielshowsky)
**[[Neurofilament]] (and Bielshowsky)
**GFAP
**[[GFAP]]
**Calretinin (focal)
**[[Calretinin]] (focal)
*Negative for:
*Negative for:
**EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]])
**EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]])
**Keratin
**[[Keratin]]
**Smooth muscle actin
**[[Smooth muscle]] [[actin]]
**Desmin
**[[Desmin]]
**Calponin
**[[Calponin]]
**Caldesmon
**[[Caldesmon]]
**p53
**[[P53]]
{| class="wikitable"
{| class="wikitable"
|+Immunohistochemical differences between Neurofibroma and Schwannoma
|+Immunohistochemical differences between Neurofibroma and Schwannoma
!Immunohistochemical stain
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Immunohistochemical stain
!Neurofibroma
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Neurofibroma
!Schwannoma
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Schwannoma
|-
|-
|'''S-100 and Sox10'''
| style="background:#DCDCDC;" align="center" + |'''[[S-100]] and [[SOX10]]'''
|Moderate positivity
|Moderate [[Positivity effect|positivity]]
|Strong, diffuse positivity
|[[Strong]], [[diffuse]] [[Positivity effect|positivity]]
|-
|-
|'''CD34'''
| style="background:#DCDCDC;" align="center" + |'''[[CD34]]'''
|Moderate
|Moderate
|Scattered cells in Antoni B areas
|Scattered [[Cells (biology)|cells]] in Antoni B [[Area|areas]]
|-
|-
|'''Neurofilament (and Bielshowsky)'''
| style="background:#DCDCDC;" align="center" + |'''[[Neurofilament]] (and Bielshowsky)'''
|Stains entrapped axons within lesion
|[[Stain|Stains]] entrapped [[axons]] within [[lesion]]
|Stains peripherally located axons of parent nerve
|[[Stain|Stains]] peripherally located [[axons]] of parent [[nerve]]
|-
|-
|'''Factor XIIIa'''
| style="background:#DCDCDC;" align="center" + |'''Factor XIIIa'''
|Moderate
|Moderate
|Negative to focal
|Negative to focal
|-
|-
|'''Calretinin'''
| style="background:#DCDCDC;" align="center" + |'''[[Calretinin]]'''
|Negative to focal
|Negative to focal
|Moderate
|Moderate
|-
|-
|'''GFAP'''
| style="background:#DCDCDC;" align="center" + |'''[[GFAP]]'''
|Variable, weak
|Variable, weak
|Variable, moderate
|[[Variable|Variable,]] moderate
|}
|}


Latest revision as of 21:48, 28 April 2019

Neurofibroma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Neurofibroma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Neurofibroma laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Neurofibroma laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Neurofibroma laboratory findings

CDC on Neurofibroma laboratory findings

Neurofibroma laboratory findings in the news

Blogs on Neurofibroma laboratory findings

Directions to Hospitals Treating Neurofibroma

Risk calculators and risk factors for Neurofibroma laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

On Immunohistochemistry, neurofibroma stains positive for S100, SOX10, CD34, factor XIIIa, neurofilament, GFAP and calretinin and negative for EMA, keratin, smooth muscle actin, desmin, calponin, caldesmon and p53.

Laboratory Findings

Immunohistochemistry of neurofibroma is as follows:

Immunohistochemical differences between Neurofibroma and Schwannoma
Immunohistochemical stain Neurofibroma Schwannoma
S-100 and SOX10 Moderate positivity Strong, diffuse positivity
CD34 Moderate Scattered cells in Antoni B areas
Neurofilament (and Bielshowsky) Stains entrapped axons within lesion Stains peripherally located axons of parent nerve
Factor XIIIa Moderate Negative to focal
Calretinin Negative to focal Moderate
GFAP Variable, weak Variable, moderate

References


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Neurofibroma_laboratory_findings&oldid=1565431"