Neurofibroma laboratory findings: Difference between revisions

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{{CMG}}; {{AE}}{{S.M.}}
{{CMG}}; {{AE}}{{S.M.}}
==Overview==
==Overview==
On [[Immunohistochemistry]], [[neurofibroma]] stains positive for [[S100A1|S100]], SOX10, [[CD34]], factor XIIIa, [[Neurofilament]] (and Bielshowsky), [[GFAP]] and [[Calretinin]] and negative for EMA, [[Keratin]], smooth muscle actin, [[Desmin]], [[Calponin]], [[Caldesmon]] and [[P53]].
On [[Immunohistochemistry]], [[neurofibroma]] [[Stain|stains]] positive for [[S100A1|S100]], [[SOX10]], [[CD34]], factor XIIIa, [[neurofilament]], [[GFAP]] and [[calretinin]] and negative for EMA, [[keratin]], [[smooth muscle]] [[actin]], [[desmin]], [[calponin]], [[caldesmon]] and [[p53]].


==Laboratory Findings==
==Laboratory Findings==
Line 9: Line 9:
*Positive for:
*Positive for:
**[[S100A1|S100]]
**[[S100A1|S100]]
**SOX10
**[[SOX10]]
**[[CD34]] (focal)
**[[CD34]] (focal)
**Factor XIIIa (focal)
**Factor XIIIa (focal)
Line 18: Line 18:
**EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]])
**EMA (except in [[Plexiform neurofibroma|plexiform neurofibromas]])
**[[Keratin]]
**[[Keratin]]
**Smooth muscle actin
**[[Smooth muscle]] [[actin]]
**[[Desmin]]
**[[Desmin]]
**[[Calponin]]
**[[Calponin]]
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! style="background:#4479BA; color: #FFFFFF;" align="center" + |Schwannoma
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Schwannoma
|-
|-
| style="background:#DCDCDC;" align="center" + |'''[[S-100]] and SOX10'''
| style="background:#DCDCDC;" align="center" + |'''[[S-100]] and [[SOX10]]'''
|Moderate positivity
|Moderate [[Positivity effect|positivity]]
|Strong, diffuse positivity
|[[Strong]], [[diffuse]] [[Positivity effect|positivity]]
|-
|-
| style="background:#DCDCDC;" align="center" + |'''[[CD34]]'''
| style="background:#DCDCDC;" align="center" + |'''[[CD34]]'''
|Moderate
|Moderate
|Scattered cells in Antoni B areas
|Scattered [[Cells (biology)|cells]] in Antoni B [[Area|areas]]
|-
|-
| style="background:#DCDCDC;" align="center" + |'''[[Neurofilament]] (and Bielshowsky)'''
| style="background:#DCDCDC;" align="center" + |'''[[Neurofilament]] (and Bielshowsky)'''
|Stains entrapped axons within lesion
|[[Stain|Stains]] entrapped [[axons]] within [[lesion]]
|Stains peripherally located axons of parent nerve
|[[Stain|Stains]] peripherally located [[axons]] of parent [[nerve]]
|-
|-
| style="background:#DCDCDC;" align="center" + |'''Factor XIIIa'''
| style="background:#DCDCDC;" align="center" + |'''Factor XIIIa'''
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| style="background:#DCDCDC;" align="center" + |'''[[GFAP]]'''
| style="background:#DCDCDC;" align="center" + |'''[[GFAP]]'''
|Variable, weak
|Variable, weak
|Variable, moderate
|[[Variable|Variable,]] moderate
|}
|}


Latest revision as of 21:48, 28 April 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

On Immunohistochemistry, neurofibroma stains positive for S100, SOX10, CD34, factor XIIIa, neurofilament, GFAP and calretinin and negative for EMA, keratin, smooth muscle actin, desmin, calponin, caldesmon and p53.

Laboratory Findings

Immunohistochemistry of neurofibroma is as follows:

Immunohistochemical differences between Neurofibroma and Schwannoma
Immunohistochemical stain Neurofibroma Schwannoma
S-100 and SOX10 Moderate positivity Strong, diffuse positivity
CD34 Moderate Scattered cells in Antoni B areas
Neurofilament (and Bielshowsky) Stains entrapped axons within lesion Stains peripherally located axons of parent nerve
Factor XIIIa Moderate Negative to focal
Calretinin Negative to focal Moderate
GFAP Variable, weak Variable, moderate

References


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