Seminoma causes: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Seminoma}}
{{Seminoma}}
{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{S.G.}}
==Overview==
==Overview==
Disease name] may be caused by [cause1], [cause2], or [cause3].
Common causes of seminoma include: [[cryptorchidism]], undeescending [[testis]], [[abdominal]] [[testis]], [[trauma]], [[mumps]], [[maternal]] [[estrogen]] [[Exposure (photography)|exposure]].Seminoma is caused by a [[mutation]] in the KIT [[gene]]. 12p11.2-p12.1 [[chromosomal]] [[Amplification|amplifications]] and [[Deletion (genetics)|deletions]] observed in majority of cases of seminoma.
 
OR
 
Common causes of [disease] include [cause1], [cause2], and [cause3].
 
OR
 
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
 
OR
 
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click [[Pericarditis causes#Overview|here]].


==Causes==
==Causes==
===Life-threatening Causes===
*Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of [[disease name]], however complications resulting from untreated [[disease name]] is common.
*Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
*[Cause] is a life-threatening cause of [disease].
===Common Causes===
===Common Causes===
Common causes of seminoma may include:<ref name="pmid23519268">{{cite journal |vauthors=Ferguson L, Agoulnik AI |title=Testicular cancer and cryptorchidism |journal=Front Endocrinol (Lausanne) |volume=4 |issue= |pages=32 |date=2013 |pmid=23519268 |doi=10.3389/fendo.2013.00032 |url=}}</ref>
Common causes of seminoma may include:<ref name="pmid23519268">{{cite journal |vauthors=Ferguson L, Agoulnik AI |title=Testicular cancer and cryptorchidism |journal=Front Endocrinol (Lausanne) |volume=4 |issue= |pages=32 |date=2013 |pmid=23519268 |doi=10.3389/fendo.2013.00032 |url=}}</ref><ref name="pmid11061944">{{cite journal |vauthors=Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH |title=Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma? |journal=J. Urol. |volume=164 |issue=6 |pages=2143–4 |date=December 2000 |pmid=11061944 |doi= |url=}}</ref>
*Cryptorchidism
*[[Cryptorchidism]]
*Undescended testis  
*Undescended [[testis]]
*Abdominal testis  
*[[Abdominal]] [[testis]]
*Trauma
*[[Trauma]]
*Mumps
*[[Mumps]]
*Maternal estrogen exposure
*[[Maternal]] [[estrogen]] [[Exposure (photography)|exposure]]


===Genetic Causes===
===Genetic Causes===
*Seminoma is caused by a mutation in the KIT gene.<ref name="pmid17943970">{{cite journal |vauthors=Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA |title=Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature |journal=Genes Chromosomes Cancer |volume=47 |issue=1 |pages=34–42 |date=January 2008 |pmid=17943970 |doi=10.1002/gcc.20503 |url=}}</ref>
*Seminoma is caused by a [[mutation]] in the KIT [[gene]].<ref name="pmid17943970">{{cite journal |vauthors=Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA |title=Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature |journal=Genes Chromosomes Cancer |volume=47 |issue=1 |pages=34–42 |date=January 2008 |pmid=17943970 |doi=10.1002/gcc.20503 |url=}}</ref>
*12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.<ref name="pmid27584029">{{cite journal |vauthors=Woldu SL, Amatruda JF, Bagrodia A |title=Testicular germ cell tumor genomics |journal=Curr Opin Urol |volume=27 |issue=1 |pages=41–47 |date=January 2017 |pmid=27584029 |pmc=6368344 |doi=10.1097/MOU.0000000000000347 |url=}}</ref>
*12p11.2-p12.1 [[chromosomal]] [[Amplification|amplifications]] and [[Deletion (genetics)|deletions]] observed in majority of cases.<ref name="pmid27584029">{{cite journal |vauthors=Woldu SL, Amatruda JF, Bagrodia A |title=Testicular germ cell tumor genomics |journal=Curr Opin Urol |volume=27 |issue=1 |pages=41–47 |date=January 2017 |pmid=27584029 |pmc=6368344 |doi=10.1097/MOU.0000000000000347 |url=}}</ref>





Latest revision as of 13:19, 15 May 2019

Seminoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Seminoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

TNM
Stage Grouping

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Treatment - Stage I
Treatment - Stage II
Treatment - Stage III
Treatment - Recurrent

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Seminoma causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Seminoma causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Seminoma causes

CDC on Seminoma causes

Seminoma causes in the news

Blogs on Seminoma causes

Directions to Hospitals Treating Seminoma

Risk calculators and risk factors for Seminoma causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

Common causes of seminoma include: cryptorchidism, undeescending testis, abdominal testis, trauma, mumps, maternal estrogen exposure.Seminoma is caused by a mutation in the KIT gene. 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases of seminoma.

Causes

Common Causes

Common causes of seminoma may include:[1][2]

Genetic Causes


References

  1. Ferguson L, Agoulnik AI (2013). "Testicular cancer and cryptorchidism". Front Endocrinol (Lausanne). 4: 32. doi:10.3389/fendo.2013.00032. PMID 23519268.
  2. Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH (December 2000). "Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma?". J. Urol. 164 (6): 2143–4. PMID 11061944.
  3. Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA (January 2008). "Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature". Genes Chromosomes Cancer. 47 (1): 34–42. doi:10.1002/gcc.20503. PMID 17943970.
  4. Woldu SL, Amatruda JF, Bagrodia A (January 2017). "Testicular germ cell tumor genomics". Curr Opin Urol. 27 (1): 41–47. doi:10.1097/MOU.0000000000000347. PMC 6368344. PMID 27584029.

Template:WH Template:WS