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| {|
| | ==pic== |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Category
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| |
| ! colspan="2" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" + |Clinical manifestation
| |
| ! colspan="5" align="center" style="background:#4479BA; color: #FFFFFF;" + |Laboratory testing
| |
| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| |-
| |
| ! rowspan="16" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet disorders
| |
| ! rowspan="7" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Thrombocytopenia]]
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Infection]]-Induced [[thrombocytopenia]]<ref name="HerbingerSchunk2012">{{cite journal|last1=Herbinger|first1=K.-H.|last2=Schunk|first2=M.|last3=Nothdurft|first3=H. D.|last4=von Sonnenburg|first4=F.|last5=Löscher|first5=T.|last6=Bretzel|first6=G.|title=Comparative study on infection-induced thrombocytopenia among returned travellers|journal=Infection|volume=40|issue=4|year=2012|pages=373–379|issn=0300-8126|doi=10.1007/s15010-012-0242-9}}</ref>
| |
| | |
| | align="left" style="background:#F5F5F5;" |
| |
| * History of prior infection
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Medication]]-Induced [[Thrombocytopenia|Thrombocytopenia]]<ref name="EltingCantor2003">{{cite journal|last1=Elting|first1=Linda S.|last2=Cantor|first2=Scott B.|last3=Martin|first3=Charles G.|last4=Hamblin|first4=Lois|last5=Kurtin|first5=Danna|last6=Rivera|first6=Edgardo|last7=Vadhan-Raj|first7=Saroj|last8=Benjamin|first8=Robert S.|title=Cost of chemotherapy-induced thrombocytopenia among patients with lymphoma or solid tumors|journal=Cancer|volume=97|issue=6|year=2003|pages=1541–1550|issn=0008-543X|doi=10.1002/cncr.11195}}</ref>
| |
| | align="left" style="background:#F5F5F5;" |
| |
| *History of [[Medication|medications]] such as:
| |
| ** [[Furosemide]]
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| ** [[Non-steroidal anti-inflammatory drug|Nonsteroidal anti-inflammatory drugs]] ([[Non-steroidal anti-inflammatory drug|NSAIDs]])
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| ** [[Penicillin]]
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| ** [[Quinidine]]
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| ** [[Quinine]]
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| ** [[Ranitidine]]
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| ** [[Sulfonamide (medicine)|Sulfonamides]]
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| ** [[Linezolid]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Most important part of treatment is discontinuing of the medication.
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Heparin-Induced Thrombocytopenia|Heparin-Induced thrombocytopenia]]<ref name="Miller2003">{{cite journal|last1=Miller|first1=Penny L.|title=Heparin-induced Thrombocytopenia Recognition and Treatment|journal=AORN Journal|volume=78|issue=1|year=2003|pages=79–89|issn=00012092|doi=10.1016/S0001-2092(06)61348-3}}</ref>
| |
| | align="left" style="background:#F5F5F5;" |
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| * [[Thrombosis]]
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| * Unexplained [[thrombocytopenia]] up to 3 weeks after the end of [[heparin]] therapy
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
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| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | For more information click here: [[Heparin-induced thrombocytopenia]].
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Idiopathic thrombocytopenic purpura|Immune Thrombocytopenic Purpura]]<ref name="CurtisKaliszewski2006">{{cite journal|last1=Curtis|first1=Brian R.|last2=Kaliszewski|first2=James|last3=Marques|first3=Marisa B.|last4=Saif|first4=M. Wasif|last5=Nabelle|first5=Lisle|last6=Blank|first6=Jules|last7=McFarland|first7=Janice G.|last8=Aster|first8=Richard H.|title=Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin|journal=American Journal of Hematology|volume=81|issue=3|year=2006|pages=199–201|issn=0361-8609|doi=10.1002/ajh.20516}}</ref>
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * History of prior [[infection]] or no history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Inherited [[Thrombocytopenia]]<ref name="Drachman2004">{{cite journal|last1=Drachman|first1=J. G.|title=Inherited thrombocytopenia: when a low platelet count does not mean ITP|journal=Blood|volume=103|issue=2|year=2004|pages=390–398|issn=0006-4971|doi=10.1182/blood-2003-05-1742}}</ref>
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Thrombotic thrombocytopenic purpura|Thrombotic Thrombocytopenic Purpura]]<ref name="George2006">{{cite journal|last1=George|first1=James N.|title=Thrombotic Thrombocytopenic Purpura|journal=New England Journal of Medicine|volume=354|issue=18|year=2006|pages=1927–1935|issn=0028-4793|doi=10.1056/NEJMcp053024}}</ref>
| |
| | align="left" style="background:#F5F5F5;" | History of:
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| *[[Cancer]]
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| *[[Bone marrow transplantation]]
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| *[[Pregnancy]]
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| *[[Medication]]
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| **[[Platelet]] aggregation inhibitors ([[ticlopidine]] and [[clopidogrel]])
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| **Immunosuppressants ([[cyclosporine]], [[mitomycin]], [[tacrolimus]]/FK506, [[interferon|interferon-α]])
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| *[[HIV-1]] infection
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| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Hemolytic-uremic syndrome|Hemolytic Uremic Syndrome]]<ref name="Noris2005">{{cite journal|last1=Noris|first1=M.|title=Hemolytic Uremic Syndrome|journal=Journal of the American Society of Nephrology|volume=16|issue=4|year=2005|pages=1035–1050|issn=1046-6673|doi=10.1681/ASN.2004100861}}</ref>
| |
| | align="left" style="background:#F5F5F5;" |History of:
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| * [[Infections]]
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| * [[Malignancy]], [[chemotherapy]], and [[ionizing radiation]]
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| * [[Calcineurin inhibitor]]s and [[transplantation]]
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| * [[Pregnancy]], [[HELLP syndrome]], and [[oral contraceptive pill]]
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| * [[Systemic lupus erythematosis]]
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| * [[Antiphospholipid syndrome|Antiphospholipid antibody syndrome]]
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| * [[Glomerulopathy]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |-
| |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |Thromobcytosis
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| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Iron deficiency anemia|Iron deficiency anemia]]
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| Inflammatory diseases
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| | |
| [[Splenectomy]]
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| | |
| [[Essential thrombocytosis|Essential thrombocytosis]]
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| | align="left" style="background:#F5F5F5;" |
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| * Digital [[pain]]
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| * [[Gangrene]]
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| * [[Erythromelalgia]]
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| * H[[eadache]]
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| * [[Paresthesia|Paresthesias]]
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| * [[Transient ischemic attack|Transient ischemic attacks]]
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! rowspan="6" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Qualitative Disorders of [[Platelet]] Function
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| ! rowspan="4" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Inherited Disorders of [[Platelet]] Function
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| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Glanzmann's thrombasthenia|Glanzmann’s thrombasthenia]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Rare
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * AR inheritance
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| * Absence of the platelet Gp IIb/IIIa receptor
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| * Diminished for GP 2B-3A on [[Flow cytometry|flow cytometry]]
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| |-
| |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Bernard-Soulier syndrome]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * AR inheritance
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| * Absence of the platelet Gp Ib-IX-V receptor
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| * On PBS: giant platelets
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| * Ristocetin - no aggregation
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| |-
| |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Wiskott-Aldrich syndrome]]
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| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
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| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
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| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Anti-WASP antibody can be used to detect presence or absence of WAS protein
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| * In Wiskott–Aldrich syndrome, the [[Platelet|platelets]] are small and do not function properly. They are removed by the [[spleen]], which leads to low [[platelet]] counts.
| |
| |-
| |
| ! align="left" style="padding: 5px 5px; background: #DCDCDC;" |Platelet storage pool disorder:
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| *[[Hermansky-Pudlak syndrome]]
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| *[[Chediak-Higashi syndrome]]
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| *[[Gray platelet syndrome]]
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| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| * [[Hairy cell leukemia]]
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| * [[Cardiovascular bypass]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * AD inheritance
| |
| * AbNlities of platelet granule formation
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Acquired Disorders of [[Platelet]] Function
| |
| | align="left" style="background:#F5F5F5 " |
| |
| * [[Chronic renal failure pathophysiology|Uremia]]
| |
| * [[Cardiopulmonary bypass]]
| |
| * Hematologic disorders such as: [[Myeloproliferative disease|myeloproliferative]] and [[Myelodysplastic syndrome|myelodysplastic syndromes]]
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | Nl or ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Von Willebrand disease|Von Willebrand Disease]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Easy bruising
| |
| * [[Epistaxis]]
| |
| * Oral cavity bleeding
| |
| * Bleeding after dental extraction/surgery
| |
| * [[Menorrhagia]]
| |
| * [[Postpartum hemorrhage]]
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" | <nowiki>+</nowiki>
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | See the table below for the details about different types.
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |-
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Vessel wall disorders
| |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Metabolism|Metabolic]] and [[Inflammation|Inflammatory]] Disorders
| |
| ! colspan="2" align="left" style="padding: 5px 5px; background: #DCDCDC;" |
| |
| * Acute febrile illnesses
| |
| * [[Cryoglobulinemia|Mixed cryoglobulinemia]]
| |
| * [[Monoclonal gammopathy|Monoclonal gammopathies]]
| |
| * [[Rocky Mountain spotted fever]]
| |
| * [[Vitamin C deficiency]]
| |
| * [[Cushing's syndrome|Cushing’s syndrome]]
| |
| * Chronic [[glucocorticoid]] therapy
| |
| * [[Vasculitis]] such as Henoch-Schönlein Purpura
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * History of the underlying disease
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |-
| |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |Inherited Disorders of the [[Vessel wall|Vessel Wall]]
| |
| ! colspan="2" align="left" style="background:#DCDCDC;" |
| |
| * [[Marfan's syndrome|Marfan’s syndrome]]
| |
| * [[Ehlers-Danlos syndrome]]
| |
| * [[Pseudoxanthoma elasticum]]
| |
| * [[Hereditary hemorrhagic telangiectasia]] ([[Hereditary hemorrhagic telangiectasia|HHT]], or [[Osler-Weber-Rendu|Osler-Weber-Rendu disease]])
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |-
| |
| ! rowspan="15" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Coagulation factor disorders
| |
| <ref name="pmid28966616" />
| |
| ! align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Fibrinogen]] deficiency
| |
| ! colspan="2" align="left" style="padding: 5px 5px; background: #DCDCDC;" |
| |
| Different types of the [[fibrinogen]] disorders:
| |
| * [[Fibrinogen#Congenital afibrinogenemia|Congenital afibrinogenemia]]
| |
| * [[Fibrinogen#Congenital hypofibrinogenemia|Congenital hypofibrinogenemia]]
| |
| * [[Fibrinogen#Fibrinogen storage disease|Fibrinogen storage disease]]
| |
| * [[Fibrinogen#Congenital dysfibrinogenemia|Congenital dysfibrinogenemia]]
| |
| * [[Fibrinogen#Hereditary fibrinogen A.CE.B1-Chain amyloidosis|Hereditary fibrinogen Aα-Chain amyloidosis]]
| |
| * [[Fibrinogen#Acquired dysfibrinogenemia|Acquired dysfibrinogenemia]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * [[Epistaxis]]
| |
| * Easy [[Bruise|bruising]]
| |
| * [[Menorrhagia]]
| |
| * [[Muscle]] bleeds
| |
| * [[Hemarthrosis]]
| |
| * [[Bleeding]] from the [[umbilical cord]] stump after birth
| |
| * Bleeding after [[dental surgery]] or tooth extraction
| |
| * AbNl bleeding during or after injury, surgery, or childbirth
| |
| * [[Gastrointestinal tract|Gastrointestinal]] [[hemorrhage]]
| |
| * [[Cerebral hemorrhage]]
| |
| * [[Thrombosis]]
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Impaired fibrin cross-linking or clot dissolution
| |
| * Mild or severe bleeding idepend on levels of functional fibrinogen
| |
| * Variable age of onset
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |-
| |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Prothrombin deficiency]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * [[Epistaxis]]
| |
| * Soft-tissue hemorrhage
| |
| * Excessive postoperative bleeding
| |
| * [[Menorrhagia]]
| |
| * Muscle [[Hematoma|hematomas]]
| |
| * [[Hemarthrosis]]
| |
| * [[Intracranial hemorrhage|Intracranial]] bleeding
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| |-
| |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor V deficiency]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Excessive bruising with minor injuries
| |
| * [[Epistaxis]]
| |
| * [[Hemarthrosis]]
| |
| * [[Menorrhagia]]
| |
| * [[Intracerebral hemorrhage|Intracerebral hemorrhages]]
| |
| * [[Pulmonary hemorrhage]]
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | −
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| * The severity of bleeding related to the degree of factor V deficiency
| |
| |-
| |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor VII deficiency]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Easy [[Bruise|bruising]]
| |
| * Mucosal bleeding
| |
| * Postoperative bleeding
| |
| * [[Menorrhagia]]
| |
| * Soft tissue hematomas
| |
| * [[Thrombosis]]
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Thrombosis in inherited factor VII deficiency
| |
| * Treatment with the administration of factor VII replacement therapy
| |
| |-
| |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor X deficiency]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Prolonged bleeding following circumcision
| |
| * Easy [[Bruise|bruising]]
| |
| * [[Hematuria]]
| |
| * [[Menorrhagia]]
| |
| * Abortion
| |
| * Postpartum hemorrhage
| |
| * Epistaxis
| |
| * Pseudotumors
| |
| * Intracranial bleeding
| |
| * Hemarthroses
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |-
| |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor XII|Factor XII deficiency]]
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Asymptomatic
| |
| * Recurrent miscarriages
| |
| * Painful leg ulcers
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |-
| |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[High-molecular-weight kininogen|High molecular weight kininogen (HMWK)]] deficiency
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history of bleeding
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| |-
| |
| ! colspan="3" rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Prekallikrein]] deficiency
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history of bleeding
| |
| | align="center" style="background:#F5F5F5;" |
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |
| |
| |-
| |
| ! rowspan="1" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Factor XIII deficiency]]<ref>{{cite journal | vauthors = Dorgalaleh A, Naderi M, Hosseini MS, Alizadeh S, Hosseini S, Tabibian S |display-authors=etal | title = Factor XIII Deficiency in Iran: A Comprehensive Review of the Literature. Seminars in thrombosis and hemostasis; | volume = 41 | issue = 3 (41) | pages = 323–329 | date=2015}}</ref>
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |
| |
| * Sub unit A mutation disease (more common)
| |
| * Sub unit B mutation disease
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history of bleeding
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |±
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl or ↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Impaired fibrin cross-linking or clot dissolution
| |
| * The severity of factor XIII deficiency bleeds can be different in different patients
| |
| |-
| |
| ! rowspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Hemophilia]]<ref name="pmid26897598">{{cite journal |vauthors=Peyvandi F, Garagiola I, Young G |title=The past and future of haemophilia: diagnosis, treatments, and its complications |journal=Lancet |volume=388 |issue=10040 |pages=187–97 |date=July 2016 |pmid=26897598 |doi=10.1016/S0140-6736(15)01123-X |url=}}</ref>
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Type A deficiency
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Eeasy [[Bruise|bruising]]
| |
| * Inadequate clotting in [[trauma]] or mild injury
| |
| * Spontaneous hemorrhage
| |
| * [[Hemarthrosis]]
| |
| * [[Epistaxis]]
| |
| * [[Gingival bleeding]]
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Type B deficiency
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Neonatal bleeding
| |
| * Trauma-related soft tissue hemorrhage
| |
| * [[Hemarthrosis]]
| |
| * [[Hematoma|Hematomas]]
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |-
| |
| ! colspan="2" align="center" style="padding: 5px 5px; background: #DCDCDC;" |Type C deficiency
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Positive family history
| |
| * Bleeding after surgery or injury
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Rare
| |
| | align="center" style="background:#F5F5F5;" |Rare
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |-
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subcategory
| |
| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |History
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mucosal bleeding
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Petechia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Ecchymoses
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Menorrhagia
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hematoma
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hemarthrosis
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |BT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |PTT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |TT
| |
| ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Comments
| |
| |-
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rare diseases
| |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Disseminated intravascular coagulation|Disseminated Intravascular Coagulation]]<ref name="pmid580488">{{cite journal |vauthors=Siegal T, Seligsohn U, Aghai E, Modan M |title=Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases |journal=Thromb. Haemost. |volume=39 |issue=1 |pages=122–34 |date=February 1978 |pmid=580488 |doi= |url=}}</ref><ref name="pmid19222477">{{cite journal |vauthors=Levi M, Toh CH, Thachil J, Watson HG |title=Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology |journal=Br. J. Haematol. |volume=145 |issue=1 |pages=24–33 |date=April 2009 |pmid=19222477 |doi=10.1111/j.1365-2141.2009.07600.x |url=}}</ref><ref name="pmid18066597">{{cite journal |vauthors=Ghosh K, Shetty S |title=Blood coagulation in falciparum malaria--a review |journal=Parasitol. Res. |volume=102 |issue=4 |pages=571–6 |date=March 2008 |pmid=18066597 |doi=10.1007/s00436-007-0832-0 |url=}}</ref><ref name="pmid5804882">{{cite journal |vauthors=Siegal T, Seligsohn U, Aghai E, Modan M |title=Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases |journal=Thromb. Haemost. |volume=39 |issue=1 |pages=122–34 |date=February 1978 |pmid=580488 |doi= |url=}}</ref><ref name="pmid1531791">{{cite journal |vauthors=Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P |title=Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies |journal=Chest |volume=101 |issue=3 |pages=816–23 |date=March 1992 |pmid=1531791 |doi= |url=}}</ref>
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * [[Trauma]]
| |
| * [[Burn]]
| |
| * [[Crush injury]]
| |
| * [[Sepsis]]
| |
| * [[Malignancy]]
| |
| * Obstetric complication: abruption, amniotic fluid embolism
| |
| * [[Hemolytic anemia]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |↓
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |-
| |
| ! colspan="3" align="center" style="padding: 5px 5px; background: #DCDCDC;" |[[Vitamin K Deficiency]]<ref name="pmid165052572">{{cite journal| author=Dezee KJ, Shimeall WT, Douglas KM, Shumway NM, O'malley PG| title=Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. | journal=Arch Intern Med | year= 2006 | volume= 166 | issue= 4 | pages= 391-7 | pmid=16505257 | doi=10.1001/.391 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16505257 }}</ref>
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Bleeding after trauma
| |
| * [[Epistaxis]]
| |
| * [[Hematoma]]
| |
| * Gastrointestinal bleeding
| |
| * [[Menorrhagia]]
| |
| * [[Hematuria]]
| |
| * Gum bleeding
| |
| * Oozing from venipuncture sites
| |
| * Easy [[Bruise|bruisability]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |↑
| |
| | align="center" style="background:#F5F5F5;" |Nl or mildly prolonged
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| |}
| |
| | |
| {| | | {| |
| |[[image:LowKECG.png|thumb|700px|center|An ECG in a person with a potassium level of 1.1 showing the classical ECG changes of ST segment depression, inverted T waves, large U waves, and a slightly prolonged PR interval. By James Heilman, MD - Own work, CC BY-SA 3.0<ref name="urlFile:LowKECG.JPG - Wikimedia Commons">{{cite web |url=https://commons.wikimedia.org/w/index.php?curid=12210926 |title=File:LowKECG.JPG - Wikimedia Commons |format= |work= |accessdate=}}</ref>]] | | |[[image:LowKECG.png|thumb|700px|center|An ECG in a person with a potassium level of 1.1 showing the classical ECG changes of ST segment depression, inverted T waves, large U waves, and a slightly prolonged PR interval. By James Heilman, MD - Own work, CC BY-SA 3.0]] |
| |} | | |} |
| <br style="clear:left" /> | | <br style="clear:left" /> |
|
| |
|
| [[image:LowKECG.png|thumb|700px|center|An ECG in a person with a potassium level of 1.1 showing the classical ECG changes of ST segment depression, inverted T waves, large U waves, and a slightly prolonged PR interval. By James Heilman, MD - Own work, CC BY-SA 3.0<ref name="urlFile:LowKECG.JPG - Wikimedia Commons">{{cite web |url=https://commons.wikimedia.org/w/index.php?curid=12210926 |title=File:LowKECG.JPG - Wikimedia Commons |format= |work= |accessdate=}}</ref>]] | | [[image:LowKECG.png|thumb|700px|right|An ECG in a person with a potassium level of 1.1 showing the classical ECG changes of ST segment depression, inverted T waves, large U waves, and a slightly prolonged PR interval. By James Heilman, MD - Own work, CC BY-SA 3.0]] |
| <br style="clear:left" /> | | <br style="clear:left" /> |
|
| |
|
Line 758: |
Line 19: |
| | align="left" style="background:#F5F5F5;" + | | | | align="left" style="background:#F5F5F5;" + | |
| *[[Lung]] | | *[[Lung]] |
| | align="left" style="background:#F5F5F5;" + | | | | align="center" style="background:#F5F5F5;" + | |
| *[[Lung]] | | *[[Lung]] |
| |} | | |} |
| <br>
| |
| <references />
| |