Neurofibroma MRI: Difference between revisions

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Latest revision as of 16:02, 26 May 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]

Overview

MRI may be helpful in the diagnosis of neurofibroma. It appears as a hypointense, homogeneous low signal intensity lesion with center demonstrating a higher signal intensity than the periphery on T1. T2 weighted images show hyperintense, homogeneous lesion with positive target sign and fascicular sign. Moreover, neurofibromas have heterogeneous enhancement on T1 C+ (Gd) (with gadolinium contrast).

MRI

MRI may be helpful in the diagnosis of neurofibroma
MRI signal characteristics include:^[1]^[2]


MRI sequence	Characteristics
T1	Hypointense Homogeneous low signal intensity Center demonstrating a higher signal intensity than the periphery (reverse of target sign on T2)
T2	Hyperintense Homogeneous high signal intensity (higher than fat) Target sign (plexiform neurofibromas) Low signal intensity centrally with a ring of high signal intensity peripherally Due to a dense central area of collagenous stroma Highly suggestive of neurofibroma but occasionally also seen in schwannomas and malignant peripheral nerve sheath tumors Fascicular sign Plexiform neurofibromas may appear as a larger and more infiltrating mass with lobulated borders with inhomogeneous enhancement Myxoid stroma enhancement helps differentiating the high signal intensity at T2-weighted imaging from cystic change or necrosis
T1 C+ (Gd) (with gadolinium contrast)	Heterogenous enhancement

References

↑ Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015
↑ https://pubs.rsna.org/doi/10.1148/rg.24si035170#REF8

Template:WikiDoc Sources

[radio-1] Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015

[2] ttps://pubs.rsna.org/doi/10.1148/rg.24si035170#REF8

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Neurofibroma}}
-{{CMG}}; {{AE}} {{SC}}
+{{CMG}}; {{AE}}{{S.M.}} {{SC}}
 ==Overview==
-[[MRI]] may be helpful in the diagnosis of neurofibroma.
+[[MRI]] may be helpful in the [[diagnosis]] of [[neurofibroma]]. It [[Appearance|appears]] as a hypointense, [[homogeneous]] low [[Signal (biology)|signal]] [[intensity]] [[lesion]] with center demonstrating a higher [[Signal (biology)|signal]] [[intensity]] than the [[periphery]] on [[T1]]. T2 [[Weighted mean|weighted]] [[images]] show hyperintense, [[homogeneous]] [[lesion]] with positive [[Target cell|target]] [[Sign (medicine)|sign]] and [[Fascicle|fascicular]] [[Sign (medicine)|sign]]. Moreover, [[Neurofibroma|neurofibromas]] have [[heterogeneous]] enhancement on [[T1]] C+ (Gd) (with [[gadolinium]] [[contrast]]).
 ==MRI==
-* [[MRI]] may be helpful in the diagnosis of neurofibroma.
+* [[MRI]] may be helpful in the [[diagnosis]] of [[neurofibroma]]
-* MRI signal characteristics include:
+* [[Magnetic resonance imaging|MRI]] [[Signal (biology)|signal]] characteristics include:<ref name="radio">Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015 </ref><ref>https://pubs.rsna.org/doi/10.1148/rg.24si035170#REF8</ref>
-:* T1 weighted image:
+{| class="wikitable"
-:* T2 weighted image:
+|+
-:* T1 with gadolinium contrast:
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |MRI sequence
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Characteristics
+|-
+| style="background:#DCDCDC;" align="center" + |'''[[T1]]'''
+|
+* Hypointense
+* [[Homogeneous]] low [[Signal (biology)|signal]] [[intensity]]
+* Center demonstrating a higher [[Signal (biology)|signal]] [[intensity]] than the [[periphery]] (reverse of [[Target cell|target]] [[Sign (medicine)|sign]] on T2)
+|-
+| style="background:#DCDCDC;" align="center" + |'''T2'''
+|
+* Hyperintense
+* [[Homogenous|Homogeneous]] high [[Signal (biology)|signal]] [[intensity]] (higher than [[fat]])
+* [[Target cell|Target]] [[Sign (medical)|sign]] ([[Plexiform neurofibroma|plexiform neurofibromas]])
+** Low [[Signal (biology)|signal]] [[intensity]] [[Central|centrally]] with a ring of high [[Signal (biology)|signal]] [[intensity]] peripherally
+** Due to a [[dense]] [[central]] [[area]] of [[collagenous]] [[stroma]]
+** Highly suggestive of [[neurofibroma]] but occasionally also seen in [[schwannomas]] and [[Malignant peripheral nerve sheath tumor|malignant peripheral nerve sheath tumors]]
+* [[Fascicle|Fascicular]] [[Sign (medical)|sign]]
+* [[Plexiform neurofibroma|Plexiform neurofibromas]] may [[Appearance|appear]] as a larger and more [[Infiltration (medical)|infiltrating]] [[mass]] with [[Lobular|lobulated]] [[Borderline|borders]] with inhomogeneous enhancement
+* Myxoid [[stroma]] enhancement helps differentiating the high [[Signal (biology)|signal]] [[intensity]] at T2-[[Weighted mean|weighted]] [[imaging]] from [[cystic]] change or [[necrosis]]
+|-
+| style="background:#DCDCDC;" align="center" + |'''[[T1]] C+ (Gd) (with [[gadolinium]] [[contrast]])'''
+|
+* Heterogenous enhancement
+|}
 ==References==
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+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Neurology]]
+[[Category:Neurosurgery]]

Neurofibroma MRI: Difference between revisions

Latest revision as of 16:02, 26 May 2019

Overview

MRI

References

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