Neurofibroma MRI: Difference between revisions
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==Overview== | ==Overview== | ||
[[MRI]] may be helpful in the diagnosis of neurofibroma. | [[MRI]] may be helpful in the [[diagnosis]] of [[neurofibroma]]. It [[Appearance|appears]] as a hypointense, [[homogeneous]] low [[Signal (biology)|signal]] [[intensity]] [[lesion]] with center demonstrating a higher [[Signal (biology)|signal]] [[intensity]] than the [[periphery]] on [[T1]]. T2 [[Weighted mean|weighted]] [[images]] show hyperintense, [[homogeneous]] [[lesion]] with positive [[Target cell|target]] [[Sign (medicine)|sign]] and [[Fascicle|fascicular]] [[Sign (medicine)|sign]]. Moreover, [[Neurofibroma|neurofibromas]] have [[heterogeneous]] enhancement on [[T1]] C+ (Gd) (with [[gadolinium]] [[contrast]]). | ||
==MRI== | ==MRI== | ||
* [[MRI]] may be helpful in the diagnosis of neurofibroma | * [[MRI]] may be helpful in the [[diagnosis]] of [[neurofibroma]] | ||
* MRI signal characteristics include:<ref name="radio">Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015 </ref> | * [[Magnetic resonance imaging|MRI]] [[Signal (biology)|signal]] characteristics include:<ref name="radio">Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015 </ref><ref>https://pubs.rsna.org/doi/10.1148/rg.24si035170#REF8</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
|+ | |+ | ||
!MRI sequence | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |MRI sequence | ||
!Characteristics | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Characteristics | ||
|- | |- | ||
|'''T1''' | | style="background:#DCDCDC;" align="center" + |'''[[T1]]''' | ||
| | | | ||
* Hypointense | * Hypointense | ||
* Homogeneous low signal intensity | * [[Homogeneous]] low [[Signal (biology)|signal]] [[intensity]] | ||
* Center demonstrating a higher signal intensity than the periphery (reverse of target sign on T2) | * Center demonstrating a higher [[Signal (biology)|signal]] [[intensity]] than the [[periphery]] (reverse of [[Target cell|target]] [[Sign (medicine)|sign]] on T2) | ||
|- | |- | ||
|'''T2''' | | style="background:#DCDCDC;" align="center" + |'''T2''' | ||
| | | | ||
* Hyperintense | * Hyperintense | ||
* Homogeneous high signal intensity (higher than fat) | * [[Homogenous|Homogeneous]] high [[Signal (biology)|signal]] [[intensity]] (higher than [[fat]]) | ||
* Target sign ( | * [[Target cell|Target]] [[Sign (medical)|sign]] ([[Plexiform neurofibroma|plexiform neurofibromas]]) | ||
* Plexiform neurofibromas may appear as a larger and more infiltrating mass with lobulated borders with inhomogeneous enhancement | ** Low [[Signal (biology)|signal]] [[intensity]] [[Central|centrally]] with a ring of high [[Signal (biology)|signal]] [[intensity]] peripherally | ||
* Myxoid stroma enhancement helps differentiating the high signal intensity at T2-weighted imaging from cystic change or necrosis | ** Due to a [[dense]] [[central]] [[area]] of [[collagenous]] [[stroma]] | ||
** Highly suggestive of [[neurofibroma]] but occasionally also seen in [[schwannomas]] and [[Malignant peripheral nerve sheath tumor|malignant peripheral nerve sheath tumors]] | |||
* [[Fascicle|Fascicular]] [[Sign (medical)|sign]] | |||
* [[Plexiform neurofibroma|Plexiform neurofibromas]] may [[Appearance|appear]] as a larger and more [[Infiltration (medical)|infiltrating]] [[mass]] with [[Lobular|lobulated]] [[Borderline|borders]] with inhomogeneous enhancement | |||
* Myxoid [[stroma]] enhancement helps differentiating the high [[Signal (biology)|signal]] [[intensity]] at T2-[[Weighted mean|weighted]] [[imaging]] from [[cystic]] change or [[necrosis]] | |||
|- | |- | ||
|'''T1 with gadolinium contrast''' | | style="background:#DCDCDC;" align="center" + |'''[[T1]] C+ (Gd) (with [[gadolinium]] [[contrast]])''' | ||
| | | | ||
* Heterogenous enhancement | * Heterogenous enhancement | ||
Latest revision as of 16:02, 26 May 2019
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Neurofibroma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Neurofibroma MRI On the Web |
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American Roentgen Ray Society Images of Neurofibroma MRI |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]
Overview
MRI may be helpful in the diagnosis of neurofibroma. It appears as a hypointense, homogeneous low signal intensity lesion with center demonstrating a higher signal intensity than the periphery on T1. T2 weighted images show hyperintense, homogeneous lesion with positive target sign and fascicular sign. Moreover, neurofibromas have heterogeneous enhancement on T1 C+ (Gd) (with gadolinium contrast).
MRI
| MRI sequence | Characteristics |
|---|---|
| T1 | |
| T2 |
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| T1 C+ (Gd) (with gadolinium contrast) |
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References
- ↑ Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015
- ↑ https://pubs.rsna.org/doi/10.1148/rg.24si035170#REF8