Squamous cell carcinoma of the skin classification: Difference between revisions

Jump to navigation Jump to search
← Older edit
VisualWikitext
Jyostna Chouturi (talk | contribs)
nocaptcha
9,554 edits
No edit summary
No edit summary
 
(8 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Squamous cell carcinoma}}
{{Squamous cell carcinoma}}
{{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:Aditya Govindavarjhulla|Aditya Govindavarjhulla, M.B.B.S.]] [mailto:agovi@wikidoc.org], [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]] [mailto:ravitheja.g@gmail.com]
{{CMG}}; {{AE}} {{RAK}}


== Overview ==
== Overview ==
Squamous cell carcinoma of the skin is a slow growing invasive non-melanoma skin [[tumour]], which is caused mainly by prolonged exposure to sunlight and other forms of UV radiation. Patients undergo staging as a routine part of their diagnosis and treatment. Staging of the lesion assists the physician to choose which form of treatment strategy suits the patient. The following is the [[TNM]] staging recommended by the [[American Joint Committee on Cancer]] (AJCC) for cutaneous SCC.<ref>http://www.cancer.gov/cancertopics/pdq/treatment/skin/HealthProfessional/page3</ref>


==Classification==
== Classification ==
 
{| class="wikitable"
{|style="width:80%; height:100px" border="1"
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Category
|style="height:100px"; style="width:25%" border="1" | '''Primary Tumour(T)'''
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Criteria
|-
|-bgcolor="LightSteelBlue"
| <center>'''TX''' </center>
|bgcolor="Beige"| Primary tumour cannot be assessed.
|-
|-
|-bgcolor="LightSteelBlue"
| colspan="2" style="background:#A9A9A9;" align="left" + |T - Primary tumor
|  <center> '''T0''' </center>
|bgcolor="Beige"| No evidence of primary tumour.
|-
|-
|-bgcolor="LightSteelBlue"
| style="background:#DCDCDC;" align="left" + |TX
| <center> '''Tis''' </center>
| style="background:#F5F5F5;" align="left" + |Primary tumor cannot be assessed
|bgcolor="Beige"| Carcinoma in situ.
|-
|-
|-bgcolor="LightSteelBlue"
| style="background:#DCDCDC;" align="left" + |Tis
|  <center> '''T1''' </center>
| style="background:#F5F5F5;" align="left" + |Carcinoma in situ
|bgcolor="Beige"|Tumour 2 cms or less in greatest dimension.
|-
|-bgcolor="LightSteelBlue"
| rowspan="3"  | <center>  '''T2''' </center>
|bgcolor="Beige"| Tumour greater than 2 cms in greatest dimesion.
|-
|-
|bgcolor="Beige" | Or.
| style="background:#DCDCDC;" align="left" + |T1
| style="background:#F5F5F5;" align="left" + |Tumor ≤ to 2 cm
|-
|-
|bgcolor="Beige" | Tumour any size with >= with high risk features <sup>'''^^'''</sup>.
| style="background:#DCDCDC;" align="left" + |T2
|-
| style="background:#F5F5F5;" align="left" + | Tumor > 2 cm, and ≤ to 4 cm
|-bgcolor="LightSteelBlue"
|  <center> '''T3''' </center>
|bgcolor="Beige"|Tumour with invasion of maxilla, mandible, orbit or temporal bone.
|-
|-bgcolor="LightSteelBlue"
|  <center> '''T4''' </center>
|bgcolor="Beige"|Tumour with invasion of skelton(axial or appendicular) or perineural invasion  of skull base
|- 
|}
<sup>'''^^'''</sup>High risk features are as follows.
 
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" | '''High Risk Features For Primary Tumour(T) staging'''
|-
|-
|-bgcolor="LightSteelBlue"
| style="background:#DCDCDC;" align="left" + |T3
|rowspan ="3"| '''Depth/Invasion'''
| style="background:#F5F5F5;" align="left" + |Tumor > 4 cm or minor bone erosion or perineural invasion or deep invasion
|bgcolor="Beige"| > 2mm thickness
|-
|-
|bgcolor="Beige"| Clark Level >= IV
| style="background:#DCDCDC;" align="left" + |T4
| style="background:#F5F5F5;" align="left" + |Tumor with gross cortical bone/marrow, skull base invasion and/or skull base foramen invasion
|-
|-
|bgcolor="Beige"| Perineural Invasion
| style="background:#DCDCDC;" align="center" + |T4a
| style="background:#F5F5F5;" align="left" + |Tumor with gross cortical bone/marrow invasion
|-
|-
|}
| style="background:#DCDCDC;" align="center" + |T4b
 
| style="background:#F5F5F5;" align="left" + |Tumor with skull base invasion and/or skull base foramen involvement
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" | '''Regional Lymph Nodes(N)'''
|-
|-
|-bgcolor="LightSteelBlue"
| colspan="2" style="background:#A9A9A9;" align="left" + |N - Regional lymph nodes
|  <center> '''NX''' </center>
|bgcolor="Beige"|  Regional  lymph nodes cannot be assessed.
|-
|-bgcolor="LightSteelBlue"
|  <center> '''N0''' </center>
|bgcolor="Beige"| No regional lymph node metastases.
|-
|-bgcolor="LightSteelBlue"
|  <center> '''N1''' </center>
|bgcolor="Beige"| Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimesion.
|-
|-bgcolor="LightSteelBlue"
| <center>  '''N2''' </center>
|bgcolor="Beige"| Metastasis is single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimesnion. 
|-
|-bgcolor="LightSteelBlue"
|  <center> '''N2a''' </center>
|bgcolor="Beige"| Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension.
|-
|-bgcolor="LightSteelBlue"
|  <center> '''N2b''' </center>
|bgcolor="Beige"|  Metastasis in multiple ipsilateral lymph nodes, more than 6 cm in greatest dimension.
|-
|-bgcolor="LightSteelBlue"
|  <center> '''N2c''' </center>
|bgcolor="Beige"| Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.
|- 
|-bgcolor="LightSteelBlue"
|  <center> '''N3''' </center>
|bgcolor="Beige"|Metastasis in a lymph node, more than 6 cm in greatest dimension.
|-
|}
 
{|style="width:35%; height:100px" border="1" 
|style="height:100px"; style="width:25%" border="1" | '''Metastasis (M)'''
|-
|-bgcolor="LightSteelBlue"
|  <center>  '''M0'''  </center>
|bgcolor="Beige"|  <center>  No distant Metastasis </center>
|-
|-bgcolor="LightSteelBlue"
| <center> '''M1''' </center>
|bgcolor="Beige"| <center> Distant Metastasis </center>
|-
|}
 
{| border="1"  cellpadding="4" 
|+ '''Cutaneous Squamous cell carcinoma'''
! Grouping !! TNM staging
|-
|-
| Stage 0
| style="background:#DCDCDC;" align="left" + |NX
| Tis N0 M0
| style="background:#F5F5F5;" align="left" + |Regional lymph nodes cannot be assessed
|-
|-
| Stage I
| style="background:#DCDCDC;" align="left" + |N0
| T1 N0 M0
| style="background:#F5F5F5;" align="left" + |No regional lymph node metastasis
|-
|-
| Stage II
| style="background:#DCDCDC;" align="left" + |N1
| T2 N0 M0
| style="background:#F5F5F5;" align="left" + |Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and no extranodal extension
|-
|-
|rowspan="4"| Stage III
| style="background:#DCDCDC;" align="left" + |N2
| T3 N0 M0
| style="background:#F5F5F5;" align="left" + |
* Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and presence of extranodal extension; or
* Tumor size > 3 cm but ≤ 6 cm without extranodal extension; or
* Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and presence of extranodal extension; or
* Metastases in multiple ipsilateral lymph nodes, tumor size ≤ 6 cm without extranodal extension; or
* In bilateral or contralateral lymph node(s), tumor size ≤ 6 cm without extranodal extension
|-
|-
| T1 N1 M0
| style="background:#DCDCDC;" align="center" + |N2a
| style="background:#F5F5F5;" align="left" + |
* Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and presence of extranodal involvement; or
* Single ipsilateral node larger, tumor size > 3 cm and ≤ 6 cm, without extranodal extension
|-
|-
| T2 N1 M0
| style="background:#DCDCDC;" align="center" + |N2b
| style="background:#F5F5F5;" align="left" + |Metastases in multiple ipsilateral nodes, tumor size ≤ 6 cm, and without extranodal extension
|-
|-
| T3 N1 M0
| style="background:#DCDCDC;" align="center" + |N2c
| style="background:#F5F5F5;" align="left" + |Metastases in bilateral or contralateral lymph node(s), tumor size ≤ 6 cm, and without extranodal extension
|-
|-
|rowspan="6"| Stage IV
| style="background:#DCDCDC;" align="left" + |N3
| T1 N2 M0
| style="background:#F5F5F5;" align="left" + |
* Metastasis in a lymph node, tumor size > 6 cm, and without extranodal extension; or
* In a single ipsilateral node, tumor size > 3 cm, and presence of extranodal extension; or
* Multiple ipsilateral, contralateral, or bilateral nodes with any extranodal exension; or
* Single contralateral node of any size with any extranodal extension
|-
|-
| T2 N2 M0
| style="background:#DCDCDC;" align="center" + |N3a
| style="background:#F5F5F5;" align="left" + |Metastasis in a lymph node, tumor size > 6 cm, and absence of extranodal extension
|-
|-
| T3 N2 M0
| style="background:#DCDCDC;" align="center" + |N3b
| style="background:#F5F5F5;" align="left" + |
* Metastasis in a single ipsilateral node, tumor size > 3 cm, and in presence of extranodal extension; or
* Multiple ipsilateral, contralateral, or bilateral nodes, with any extranodal extension; or
* Single contralateral node of any size and with any extranodal extension
|-
|-
| Any T N3 M0
| colspan="2" style="background:#A9A9A9;" align="left" + |M - Distant metastasis
|-
|-
| T4 Any N M0
| style="background:#DCDCDC;" align="left" + |M0
| style="background:#F5F5F5;" align="left" + |No distant metastasis
|-
|-
| Any T Any N M1
| style="background:#DCDCDC;" align="left" + |M1
| style="background:#F5F5F5;" align="left" + |Distant metastasis
|}
|}


Latest revision as of 00:04, 11 June 2019

Squamous cell carcinoma of the skin Microchapters

Home

Patient Info

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Squamous cell carcinoma of the skin from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT Scan

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Squamous cell carcinoma of the skin classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Squamous cell carcinoma of the skin classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Squamous cell carcinoma of the skin classification

CDC on Squamous cell carcinoma of the skin classification

Squamous cell carcinoma of the skin classification in the news

Blogs on Squamous cell carcinoma of the skin classification

Directions to Hospitals Treating Squamous cell carcinoma of the skin

Risk calculators and risk factors for Squamous cell carcinoma of the skin classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Classification

Category Criteria
T - Primary tumor
TX Primary tumor cannot be assessed
Tis Carcinoma in situ
T1 Tumor ≤ to 2 cm
T2 Tumor > 2 cm, and ≤ to 4 cm
T3 Tumor > 4 cm or minor bone erosion or perineural invasion or deep invasion
T4 Tumor with gross cortical bone/marrow, skull base invasion and/or skull base foramen invasion
T4a Tumor with gross cortical bone/marrow invasion
T4b Tumor with skull base invasion and/or skull base foramen involvement
N - Regional lymph nodes
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and no extranodal extension
N2
  • Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and presence of extranodal extension; or
  • Tumor size > 3 cm but ≤ 6 cm without extranodal extension; or
  • Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and presence of extranodal extension; or
  • Metastases in multiple ipsilateral lymph nodes, tumor size ≤ 6 cm without extranodal extension; or
  • In bilateral or contralateral lymph node(s), tumor size ≤ 6 cm without extranodal extension
N2a
  • Metastasis in a single ipsilateral lymph node, tumor size ≤ 3 cm, and presence of extranodal involvement; or
  • Single ipsilateral node larger, tumor size > 3 cm and ≤ 6 cm, without extranodal extension
N2b Metastases in multiple ipsilateral nodes, tumor size ≤ 6 cm, and without extranodal extension
N2c Metastases in bilateral or contralateral lymph node(s), tumor size ≤ 6 cm, and without extranodal extension
N3
  • Metastasis in a lymph node, tumor size > 6 cm, and without extranodal extension; or
  • In a single ipsilateral node, tumor size > 3 cm, and presence of extranodal extension; or
  • Multiple ipsilateral, contralateral, or bilateral nodes with any extranodal exension; or
  • Single contralateral node of any size with any extranodal extension
N3a Metastasis in a lymph node, tumor size > 6 cm, and absence of extranodal extension
N3b
  • Metastasis in a single ipsilateral node, tumor size > 3 cm, and in presence of extranodal extension; or
  • Multiple ipsilateral, contralateral, or bilateral nodes, with any extranodal extension; or
  • Single contralateral node of any size and with any extranodal extension
M - Distant metastasis
M0 No distant metastasis
M1 Distant metastasis

References


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Squamous_cell_carcinoma_of_the_skin_classification&oldid=1571578"