Ovarian cancer staging: Difference between revisions

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{{CMG}}; {{AE}} {{Hudakarman}}
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{{Ovarian cancer}}


==Overview==
==Overview==
[[Ovarian cancer]] staging is by the International [[FIGO|Federation of Gynecology and Obstetrics]] ([[FIGO]]) [[Cancer staging|staging]] system and uses information obtained after [[surgery]], which can include a total [[abdominal]] [[hysterectomy]], removal of (usually) both [[ovaries]] and [[fallopian tubes]], (usually) the [[momentum]],  and [[pelvic]] ([[peritoneal]]) washings for [[cytology]].  The [[American Joint Committee on Cancer]] ([[AJCC]]) [[Cancer staging|stage]] is the same as the [[FIGO]] stage. The [[Cancer staging|staging]] system is based on the [[surgical]] information about the [[tumor]], [[lymph nodes]], and [[metastasis]]. The evaluation of the [[tumor]] determines if it is primary or secondary, involve one [[ovary]], both [[ovaries]], or [[fallopian tube]], involve ovarian surface, capsule rupture, and if there is dense [[adhesions]].   


==Staging==
==Staging==


* [[Ovarian cancer]] staging is by the International Federation of Gynecology and Obstetrics ([[FIGO]]) staging system and uses information obtained after surgery, which can include a total abdominal [[hysterectomy]], removal of (usually) both ovaries and fallopian tubes, (usually) the [[omentum]],  and pelvic (peritoneal) washings for [[cytology]].  The American Joint Committee on Cancer ([[AJCC]]) stage is the same as the [[FIGO]] stage.
* [[Ovarian cancer]] [[Cancer staging|staging]] is by the [[International Federation of Gynecology and Obstetrics]] ([[FIGO]]) [[Cancer staging|staging]] system and uses information obtained after [[surgery]], which can include a total abdominal [[hysterectomy]], removal of (usually) both [[ovaries]] and [[fallopian tubes]], (usually) the [[momentum]],  and [[pelvic]] ([[peritoneal]]) washings for [[cytology]].  The [[American Joint Committee on Cancer]] ([[AJCC]]) stage is the same as the [[FIGO]] stage.<ref name="pmid24219974">{{cite journal| author=Prat J, FIGO Committee on Gynecologic Oncology| title=Staging classification for cancer of the ovary, fallopian tube, and peritoneum. | journal=Int J Gynaecol Obstet | year= 2014 | volume= 124 | issue= 1 | pages= 1-5 | pmid=24219974 | doi=10.1016/j.ijgo.2013.10.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24219974  }}</ref>
*The staging system is based on the surgical information about the tumor, lymph nodes, and metastasis.  
*The [[Cancer staging|staging]] system is based on the surgical information about the [[tumor]], [[lymph nodes]], and [[metastasis]].
*The following should be considered when evaluating the tumor:
*The following should be considered when evaluating the [[tumor]]:
** Is it primary or secondary
** Is it primary or secondary
** Involvement of both ovaries or ovarian tube
** Involvement of both [[ovaries]] or [[ovarian tube]]
** Involvement of ovarian surface and hence, expose peritoneum to the tumor cells
** Involvement of [[ovarian]] surface and hence, expose [[peritoneum]] to the tumor cells
** Rupture of the capsule
** Rupture of the capsule
** Presence of dense adhesions
** Presence of dense [[adhesions]]
* The staging system is the same for [[ovarian cancer]], [[fallopian tube cancer]], and [[peritoneal carcinoma]] with large variations based on the histologic subtypes<ref name="pmid24219974">{{cite journal| author=Prat J, FIGO Committee on Gynecologic Oncology| title=Staging classification for cancer of the ovary, fallopian tube, and peritoneum. | journal=Int J Gynaecol Obstet | year= 2014 | volume= 124 | issue= 1 | pages= 1-5 | pmid=24219974 | doi=10.1016/j.ijgo.2013.10.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24219974  }}</ref>
* The [[Cancer staging|staging]] system is the same for [[ovarian cancer]], [[fallopian tube cancer]], and [[Peritoneal carcinomatosis|peritoneal carcinoma]] with large variations based on the [[histologic]] subtypes
*To achieve better outcome, the surgical staging procedure should be operated by gynecologist [[Oncologist|oncologist.]]
*To achieve better outcome, the [[surgical]] staging procedure should be operated by [[Gynecologic oncology|gynecologist oncologist]].


{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
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| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Metastasis to the retroperitoneal lymph nodes with or without microscopic peritoneal involvement beyond the pelvis
*[[Metastasis]] to the [[retroperitoneal]] [[lymph nodes]] with or without microscopic [[peritoneal]] involvement beyond the [[pelvis]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA(i)]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA(i)]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Positive retroperitoneal lymph nodes only (cytologically or histologically proven)
*Positive [[retroperitoneal]] [[lymph nodes]] only ([[Cytological|cytologically]] or [[histologically]] proven)
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA(ii)]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA(ii)]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Metastasis >10 mm in greatest dimension
*[[Metastasis]] >10 mm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA2]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIA2]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes
*[[Microscopic]] extrapelvic (above the [[pelvic brim]]) [[peritoneal]] involvement with or without positive [[retroperitoneal]] [[lymph nodes]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIB]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIB]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Macroscopic peritoneal metastases beyond the pelvic brim ≤2 cm in greatest dimension, with or without metastasis to the retroperitoneal lymph nodes
*[[Macroscopic]] [[peritoneal]] [[metastases]] beyond the [[pelvic brim]] ≤ 2 cm in greatest dimension, with or without [[metastasis]] to the [[retroperitoneal]] [[lymph nodes]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIC]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IIIC]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Macroscopic peritoneal metastases beyond the pelvic brim >2 cm in greatest dimension, with or without metastases to the retroperitoneal nodes
*[[Macroscopic]] [[peritoneal]] [[metastases]] beyond the [[pelvic brim]] >2 cm in greatest dimension, with or without [[metastases]] to the [[retroperitoneal]] [[lymph nodes]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IV]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IV]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Distant metastasis excluding peritoneal metastases
*Distant [[metastasis]] excluding [[peritoneal]] [[metastases]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IVA]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IVA]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Pleural effusion with positive cytology
*[[Pleural effusion]] with positive [[cytology]]
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IVB]]'''
| style="padding: 5px 5px; background: #DCDCDC;" | '''[[IVB]]'''
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside of the abdominal cavity)
*[[Metastases]] to extra-[[abdominal organs]] (including [[inguinal lymph nodes]] and [[lymph nodes]] outside of the [[abdominal cavity]])
|-
|-


|}
{| {{table}}
| align="center" style="background:#f0f0f0;"|'''Stage'''
| align="center" style="background:#f0f0f0;"|'''Definition'''
|-
| I||Tumor confined to ovaries or fallopian tubes
|-
| IA||Tumor limited to one ovary (capsule intact) or fallopian tube; no tumor on ovarian or fallopian tube surface; no malignant cells in the ascites or peritoneal washings
|-
| IB||Tumor limited to both ovaries (capsules intact) or fallopian tubes; no tumor on ovarian or fallopian tube surface; no malignant cells in the ascites or peritoneal washings
|-
| IC||Tumor limited to one or both ovaries or fallopian tubes, with any of the following:
|-
| IC1|| Surgical spill intraoperatively
|-
| IC2|| Capsule ruptured before surgery or tumor on ovarian or fallopian tube surface
|-
| IC3|| Malignant cells present in the ascites or peritoneal washings
|-
| II||Tumor involves one or both ovaries or fallopian tubes with pelvic extension (below pelvic brim) or peritoneal cancer
|-
| IIA||Extension and/or implants on the uterus and/or fallopian tubes and/or ovaries
|-
| IIB||Extension to other pelvic intraperitoneal tissues
|-
| III||Tumor involves one or both ovaries, or fallopian tubes, or primary peritoneal cancer, with cytologically or histologically confirmed spread to the peritoneum outside of the pelvis and/or metastasis to the retroperitoneal lymph nodes
|-
| IIIA||Metastasis to the retroperitoneal lymph nodes with or without microscopic peritoneal involvement beyond the pelvis
|-
| IIIA(i)||Positive retroperitoneal lymph nodes only (cytologically or histologically proven)
|-
| IIIA(ii)||Metastasis >10 mm in greatest dimension
|-
| IIIA2||Microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes
|-
| IIIB||Macroscopic peritoneal metastases beyond the pelvic brim ≤2 cm in greatest dimension, with or without metastasis to the retroperitoneal lymph nodes
|-
| IIIC||Macroscopic peritoneal metastases beyond the pelvic brim >2 cm in greatest dimension, with or without metastases to the retroperitoneal nodes
|-
| IV||Distant metastasis excluding peritoneal metastases
|-
| IVA||Pleural effusion with positive cytology
|-
| IVB||Metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside of the abdominal cavity)
|}
|}



Latest revision as of 18:50, 12 September 2019


Ovarian cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classifications

Pathophysiology

Causes of Ovarian cancer

Differentiating Ovarian cancer from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms

Physical Examination

Staging

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ovarian cancer staging On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ovarian cancer staging

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ovarian cancer staging

CDC on Ovarian cancer staging

Ovarian cancer staging in the news

Blogs on Ovarian cancer staging

Directions to Hospitals Treating Ovarian cancer

Risk calculators and risk factors for Ovarian cancer staging

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.

Ovarian cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classifications

Pathophysiology

Causes of Ovarian cancer

Differentiating Ovarian cancer from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms

Physical Examination

Staging

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ovarian cancer staging On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ovarian cancer staging

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ovarian cancer staging

CDC on Ovarian cancer staging

Ovarian cancer staging in the news

Blogs on Ovarian cancer staging

Directions to Hospitals Treating Ovarian cancer

Risk calculators and risk factors for Ovarian cancer staging

Overview

Ovarian cancer staging is by the International Federation of Gynecology and Obstetrics (FIGO) staging system and uses information obtained after surgery, which can include a total abdominal hysterectomy, removal of (usually) both ovaries and fallopian tubes, (usually) the momentum, and pelvic (peritoneal) washings for cytology. The American Joint Committee on Cancer (AJCC) stage is the same as the FIGO stage. The staging system is based on the surgical information about the tumor, lymph nodes, and metastasis. The evaluation of the tumor determines if it is primary or secondary, involve one ovary, both ovaries, or fallopian tube, involve ovarian surface, capsule rupture, and if there is dense adhesions.

Staging

Stage Definition
I
IA
IB
IC
IC1
  • Surgical spill intraoperatively
IC2
IC3
II
IIA
IIB
III
IIIA
IIIA(i)
IIIA(ii)
IIIA2
IIIB
IIIC
IV
IVA
IVB

References

  1. Prat J, FIGO Committee on Gynecologic Oncology (2014). "Staging classification for cancer of the ovary, fallopian tube, and peritoneum". Int J Gynaecol Obstet. 124 (1): 1–5. doi:10.1016/j.ijgo.2013.10.001. PMID 24219974.