Medulloblastoma classification: Difference between revisions

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Latest revision as of 21:35, 12 September 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Associate Editor(s)-in-Chief: Syed Musadiq Ali M.B.B.S.[3]

Overview

Medulloblastoma is classified into several subtypes based on the WHO histological classification system (classic vs. variant medulloblastoma) and the molecular subtypes classification system (WNT subgroup vs. SHH subgroup vs. Group 3 medulloblastoma vs. Group 4 medulloblastoma).^[1]^[2]^[3]^[4]^[5]

Classification

WHO Histological Classification System

Medulloblastoma is classified into two main subtypes based on the WHO histological classification system which include classic medulloblastoma and variant medulloblastoma.^[2]^[4]^[5]
Variant medulloblastoma may be further classified into desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic medulloblastoma, and medulloblastoma with extensive nodularity.

WHO histological classification system

Classic medulloblastoma

Variant medulloblastoma

Desmoplastic medulloblastoma

Large cell medulloblastoma

Anaplastic medulloblastoma

Medulloblastoma with extensive nodularity

Molecular Classification System

Medulloblastoma may be classified into at least four major subgroup based on the molecular classification system which include WNT subgroup, SHH subgroup, Group 3, and Group 4.^[1]^[3]

Molecular classification system

WNT

SHH

Group 3

Group 4

WNT α
WNT β

SHH α
SHH β
SHH γ

Group 3 α
Group 3 β

Group 4 α
Group 4 β

References

↑ ^1.0 ^1.1 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T; et al. (2012). "Subgroup-specific structural variation across 1,000 medulloblastoma genomes". Nature. 488 (7409): 49–56. doi:10.1038/nature11327. PMC 3683624. PMID 22832581.
↑ ^2.0 ^2.1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
↑ ^3.0 ^3.1 Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
↑ ^4.0 ^4.1 Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015
↑ ^5.0 ^5.1 Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28 2015

[pmid22832581-1] 1.0 ^1.1 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T; et al. (2012). "Subgroup-specific structural variation across 1,000 medulloblastoma genomes". Nature. 488 (7409): 49–56. doi:10.1038/nature11327. PMC 3683624. PMID 22832581.

[pmid17618441-2] 2.0 ^2.1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.

[pmid22189395-3] 3.0 ^3.1 Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395

[patho-4] 4.0 ^4.1 Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015

[radio-5] 5.0 ^5.1 Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28 2015

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Medulloblastoma}}
-{{CMG}} {{AE}}{{HL}}
+{{CMG}} {{AE}}{{HL}} {{AE}}{{sali}}
 ==Overview==
-Medulloblastoma may be classified into several subtypes based on the WHO histological classification system (classic vs variant medulloblastoma) and the molecular subtypes classification system (''WNT'' subgroup vs ''SHH'' subgroup vs Group 3 medulloblastoma vs Group 4 medulloblastoma).<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref><ref name="patho">Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015</ref><ref name="radio">Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28 2015</ref>
+Medulloblastoma is classified into several subtypes based on the WHO histological classification system (classic vs. variant medulloblastoma) and the molecular subtypes classification system (''WNT'' subgroup vs. ''SHH'' subgroup vs. Group 3 medulloblastoma vs. Group 4 medulloblastoma).<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref><ref name="patho">Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015</ref><ref name="radio">Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28 2015</ref>
 ==Classification==
 ===WHO Histological Classification System===
-* Medulloblastoma may be classified into two main subtypes based on the WHO histological classification system which include classic medulloblastoma and variant medulloblastoma.<ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref><ref name="patho">Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015</ref><ref name="radio">Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015</ref>
+* Medulloblastoma is classified into two main subtypes based on the WHO histological classification system which include classic medulloblastoma and variant medulloblastoma.<ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref><ref name="patho">Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015</ref><ref name="radio">Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015</ref>
 * Variant medulloblastoma may be further classified into desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic medulloblastoma, and medulloblastoma with extensive nodularity.
 <br>
 {{familytree/start |summary=WHO histological classification criteria}}
-{{familytree | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 10em; padding:0em;">'''WHO histological classification system'''</div>}}
+{{familytree | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 9em; padding:0em;">'''WHO histological classification system'''</div>}}
 {{familytree | | |,|-|-|-|^|-|-|-|.| | | | | | }}
 {{familytree | | A01 | | | | | | A03 | | | | |A01=<div style="width: 10em; padding:0em;">'''Classic medulloblastoma'''</div>|A03=<div style="width: 10em; padding:0em;">|A03=<div style="width: 10em; padding:0em;">'''Variant medulloblastoma'''</div>}}
@@ Line 23: / Line 23: @@
 ===Molecular Classification System===
-* Medulloblastoma may be classified into at least four major subtypes based on molecular classification criteria which include ''WNT'' subgroup, ''SHH'' subgroup, Group C  and Group D medulloblastoma.<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref>
+* Medulloblastoma may be classified into at least four major subgroup based on the molecular classification system which include ''WNT'' subgroup, ''SHH'' subgroup, Group 3, and Group 4.<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref>
 <br>
-{{familytree/start |summary=Genomic classification criteria}}
+{{familytree/start |summary=Molecular classification criteria}}
-{{familytree | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 10em; padding:0em;">'''Genomic classification system'''</div>}}
+{{familytree | | | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 10em; padding:0em;">'''Molecular classification system'''</div>}}
-{{familytree | | |,|-|-|-|+|-|-|-|v|-|-|-|.| | }}
+{{familytree | | |,|-|-|-|v|-|^|-|v|-|-|-|.| | }}
-{{familytree | | A01 | | A02 | | A03 | | A04  | | | | | A01=<div style="width: 10em; padding:0em;">'''''WNT'' subgroup'''</div>|A02=<div style="width: 10em; padding:0em;">'''''SHH'' subgroup'''</div>|A03=<div style="width: 10em; padding:0em;">'''Group 3 medulloblastoma'''</div>|A04=<div style="width: 10em; padding:0em;">'''Group 4 medulloblastoma'''</div>}}
+{{familytree | | A01 | | A02 | | A03 | | A04  | | | | | A01=<div style="width: 10em; padding:0em;">'''''WNT'''''</div>|A02=<div style="width: 10em; padding:0em;">'''''SHH'''''</div>|A03=<div style="width: 10em; padding:0em;">'''Group 3 '''</div>|A04=<div style="width: 10em; padding:0em;">'''Group 4'''</div>}}{{familytree|boxstyle= border-top: 0px; | | A01 | | A02 | | A03 | | A04  | | | | | A01=<div style="width: 10em; padding:0em;">'''''WNT α'''''<br>'''WNT β'''</div>|A02=<div style="width: 10em; padding:0em;">'''SHH α'''<br>'''SHH β'''<br>'''SHH γ'''</div>|A03=<div style="width: 10em; padding:0em;">'''Group 3 α '''<br>'''Group 3 β'''</div>|A04=<div style="width: 10em; padding:0em;">'''Group 4 α'''<br>'''Group 4 β'''</div>}}
 {{familytree/end}}
+<br>
+<br>
 ==References==
@@ Line 38: / Line 39: @@
 [[Category:Disease]]
 [[Category:Types of cancer]]
+[[Category:Neurology]]
+[[Category:Neurosurgery]]
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
 [[Category:Neurology]]
 [[Category:Neurosurgery]]