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{{Zollinger-Ellison syndrome}}
{{Zollinger-Ellison syndrome}}


{{CMG}} {{AE}} {{MJK}}
{{CMG}} {{AE}} {{ARK}} {{MJK}}
 
==Overview==
==Overview==
Symptoms of Zollinger-Ellison syndrome include [[diarrhea]], [[odynophagia]], [[nausea]], and [[hematemesis]] .
[[Symptom|Symptoms]] of Zollinger-Ellison syndrome include [[diarrhea]], [[odynophagia]], [[nausea]], and [[hematemesis]] .
==History and Symptoms==  
 
Patients with Zollinger–Ellison syndrome may experience [[abdominal pain]] and [[diarrhea]]. The diagnosis is also suspected in patients without symptoms who have severe [[ulceration]] of the stomach and small bowel, especially if they fail to respond to treatment.
==History and Symptoms==
 
=== History ===
 
*The most common clinical manifestations include [[abdominal pain]] and [[chronic diarrhea]].<ref name="pmid28722872">{{cite journal |vauthors=Cingam S, Karanchi H |title= |journal= |volume= |issue= |pages= |year= |pmid=28722872 |doi= |url=}}</ref>
*Other manifestations may include [[dyspepsia]], [[gastroesophageal reflux]], [[gastrointestinal bleeding]], and [[weight loss]]. <ref name="pmid28722872">{{cite journal |vauthors=Cingam S, Karanchi H |title= |journal= |volume= |issue= |pages= |year= |pmid=28722872 |doi= |url=}}</ref>
 
===Common Symptoms===
Common [[Symptom|symptoms]] of Zollinger-Ellison syndrome include: <ref name="pmid28722872">{{cite journal |vauthors=Cingam S, Karanchi H |title= |journal= |volume= |issue= |pages= |year= |pmid=28722872 |doi= |url=}}</ref> <ref name="pmid24319020">{{cite journal |vauthors=Epelboym I, Mazeh H |title=Zollinger-Ellison syndrome: classical considerations and current controversies |journal=Oncologist |volume=19 |issue=1 |pages=44–50 |year=2014 |pmid=24319020 |pmc=3903066 |doi=10.1634/theoncologist.2013-0369 |url=}}</ref>
 
*[[Chronic diarrhea]]
*[[Chronic diarrhea]]
*[[Abdominal pain]]
*[[Weight loss]]
*[[Loss of appetite]]
*[[Gastrointestinal bleeding]]
*[[Gastroesophageal reflux]]
===Less Common Symptoms===
Less common [[Symptom|symptoms]] of Zollinger-Ellison syndrome include: <ref name="pmid28722872">{{cite journal |vauthors=Cingam S, Karanchi H |title= |journal= |volume= |issue= |pages= |year= |pmid=28722872 |doi= |url=}}</ref> <ref name="pmid24319020">{{cite journal |vauthors=Epelboym I, Mazeh H |title=Zollinger-Ellison syndrome: classical considerations and current controversies |journal=Oncologist |volume=19 |issue=1 |pages=44–50 |year=2014 |pmid=24319020 |pmc=3903066 |doi=10.1634/theoncologist.2013-0369 |url=}}</ref>
*[[Steatorrhea]]
*[[Steatorrhea]]
*[[Odynophagia]]
*[[Odynophagia]]
Line 14: Line 33:
*[[Hematemesis]]
*[[Hematemesis]]
*[[Malnourishment]]
*[[Malnourishment]]
*[[Weight loss]]
*[[loss of appetite]]
[[Gastrinoma]]s may occur as single tumors or as multiple, small tumors. About one-half to two-thirds of single gastrinomas are [[malignant]] tumors that most commonly spread to the [[liver]] and [[lymph node]] near the pancreas and small bowel. Nearly 25 percent of patients with gastrinomas have multiple tumors as part of a condition called [[multiple endocrine neoplasia]] type I (MEN I). MEN I patients have tumors in their [[pituitary gland]] and [[parathyroid gland]]s, in addition to tumors of the pancreas.


==References==
==References==

Latest revision as of 22:16, 18 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2] Mohamad Alkateb, MBBCh [3]

Overview

Symptoms of Zollinger-Ellison syndrome include diarrhea, odynophagia, nausea, and hematemesis .

History and Symptoms

History

Common Symptoms

Common symptoms of Zollinger-Ellison syndrome include: [1] [2]

Less Common Symptoms

Less common symptoms of Zollinger-Ellison syndrome include: [1] [2]

References

  1. 1.0 1.1 1.2 1.3 Cingam S, Karanchi H. PMID 28722872. Missing or empty |title= (help)
  2. 2.0 2.1 Epelboym I, Mazeh H (2014). "Zollinger-Ellison syndrome: classical considerations and current controversies". Oncologist. 19 (1): 44–50. doi:10.1634/theoncologist.2013-0369. PMC 3903066. PMID 24319020.

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