Zollinger-Ellison syndrome epidemiology and demographics: Difference between revisions

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==Overview==
==Overview==
The incidence of [[gastrinoma]], which can cause Zollinger-Ellison syndrome, is approximately 0.5-2/million population/year worldwide.<ref name="pmid22261919">{{cite journal| author=Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P et al.| title=ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes. | journal=Neuroendocrinology | year= 2012 | volume= 95 | issue= 2 | pages= 98-119 | pmid=22261919 | doi=10.1159/000335591 | pmc=PMC3701449 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22261919  }} </ref> About 25 to 30 percent of gastrinomas are caused by  multiple endocrine neoplasia type 1 ([[MEN1]]).<ref name="NIDDK">National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes</ref>
The incidence of [[gastrinoma]], which can cause Zollinger-Ellison syndrome, is approximately 0.05 - 0.2 per 100,000 individuals worldwide. About 25 to 30 percent of [[Gastrinoma|gastrinomas]] are caused by  [[multiple endocrine neoplasia type 1]] ([[MEN1]]).
==Incidence==
The incidence of [[gastrinoma]], which can cause Zollinger-Ellison syndrome, is approximately 0.5-2/million population/year worldwide.<ref name="pmid22261919">{{cite journal| author=Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P et al.| title=ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes. | journal=Neuroendocrinology | year= 2012 | volume= 95 | issue= 2 | pages= 98-119 | pmid=22261919 | doi=10.1159/000335591 | pmc=PMC3701449 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22261919  }} </ref>


==Age==
==Epidemiology and Demographics==
Zollinger-Ellison syndrome commonly affects individuals between the ages of 20 and 50.<ref name="pmid17108778">{{cite journal| author=Berna MJ, Hoffmann KM, Serrano J, Gibril F, Jensen RT| title=Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. | journal=Medicine (Baltimore) | year= 2006 | volume= 85 | issue= 6 | pages= 295-330 | pmid=17108778 | doi=10.1097/01.md.0000236956.74128.76 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17108778  }} </ref>
 
==Gender==
===Incidence===
Males are more commonly affected with Zollinger-Ellison syndrome than females.<ref name="pmid17108778">{{cite journal| author=Berna MJ, Hoffmann KM, Serrano J, Gibril F, Jensen RT| title=Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. | journal=Medicine (Baltimore) | year= 2006 | volume= 85 | issue= 6 | pages= 295-330 | pmid=17108778 | doi=10.1097/01.md.0000236956.74128.76 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17108778  }} </ref>
*The worldwide incidence of [[Gastrinoma|gastrinomas]] is about 5 to 30 cases per 100,000 individuals per year.<ref name="pmid28722872">{{cite journal |vauthors=Cingam SR, Karanchi H |title= |journal= |volume= |issue= |pages= |year= |pmid=28722872 |doi= |url=}}</ref>
*With improved techniques for tumor detection, the annual incidence has increased.
*About 80% to 90% of these tumors arise in the gastrinoma triangle.
 
===Age===
*Zollinger-Ellison syndrome is a disease that tends to affect the middle-aged adult population (20 - 50 years of age).<ref name="pmid17108778">{{cite journal| author=Berna MJ, Hoffmann KM, Serrano J, Gibril F, Jensen RT| title=Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. | journal=Medicine (Baltimore) | year= 2006 | volume= 85 | issue= 6 | pages= 295-330 | pmid=17108778 | doi=10.1097/01.md.0000236956.74128.76 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17108778  }} </ref>
 
===Gender===
*Males are more commonly affected with Zollinger-Ellison syndrome than females.<ref name="pmid17108778">{{cite journal| author=Berna MJ, Hoffmann KM, Serrano J, Gibril F, Jensen RT| title=Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. | journal=Medicine (Baltimore) | year= 2006 | volume= 85 | issue= 6 | pages= 295-330 | pmid=17108778 | doi=10.1097/01.md.0000236956.74128.76 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17108778  }} </ref>
 
===Race===
*There is no racial predilection to Zollinger-Ellison syndrome


==References==
==References==

Latest revision as of 15:12, 19 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

The incidence of gastrinoma, which can cause Zollinger-Ellison syndrome, is approximately 0.05 - 0.2 per 100,000 individuals worldwide. About 25 to 30 percent of gastrinomas are caused by multiple endocrine neoplasia type 1 (MEN1).

Epidemiology and Demographics

Incidence

  • The worldwide incidence of gastrinomas is about 5 to 30 cases per 100,000 individuals per year.[1]
  • With improved techniques for tumor detection, the annual incidence has increased.
  • About 80% to 90% of these tumors arise in the gastrinoma triangle.

Age

  • Zollinger-Ellison syndrome is a disease that tends to affect the middle-aged adult population (20 - 50 years of age).[2]

Gender

  • Males are more commonly affected with Zollinger-Ellison syndrome than females.[2]

Race

  • There is no racial predilection to Zollinger-Ellison syndrome

References

  1. Cingam SR, Karanchi H. PMID 28722872. Missing or empty |title= (help)
  2. 2.0 2.1 Berna MJ, Hoffmann KM, Serrano J, Gibril F, Jensen RT (2006). "Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature". Medicine (Baltimore). 85 (6): 295–330. doi:10.1097/01.md.0000236956.74128.76. PMID 17108778.

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