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==Other Imaging Findings==
==Other Imaging Findings==
Other imaging studies that may be helpful in the diagnosis of Zollinger-Ellison syndrome include: <ref name="TangWu2014">{{cite journal|last1=Tang|first1=Shou-jiang|last2=Wu|first2=Ruonan|last3=Bhaijee|first3=Feriyl|title=Zollinger–Ellison Syndrome|journal=Video Journal and Encyclopedia of GI Endoscopy|volume=1|issue=3-4|year=2014|pages=666–668|issn=22120971|doi=10.1016/j.vjgien.2013.06.005}}</ref>
Other imaging studies that may be helpful in the diagnosis of Zollinger-Ellison syndrome include: <ref name="TangWu2014">{{cite journal|last1=Tang|first1=Shou-jiang|last2=Wu|first2=Ruonan|last3=Bhaijee|first3=Feriyl|title=Zollinger–Ellison Syndrome|journal=Video Journal and Encyclopedia of GI Endoscopy|volume=1|issue=3-4|year=2014|pages=666–668|issn=22120971|doi=10.1016/j.vjgien.2013.06.005}}</ref>
*[[Somatostatin receptor]] scintigraphy (SRS) ([[octreotide]] scan)<ref name="pmid9274481">{{cite journal |vauthors=Cadiot G, Bonnaud G, Lebtahi R, Sarda L, Ruszniewski P, Le Guludec D, Mignon M |title=Usefulness of somatostatin receptor scintigraphy in the management of patients with Zollinger-Ellison syndrome. Groupe de Recherche et d'Etude du Syndrome de Zollinger-Ellison (GRESZE) |journal=Gut |volume=41 |issue=1 |pages=107–14 |year=1997 |pmid=9274481 |pmc=1027237 |doi= |url=}}</ref>
*[[Somatostatin receptor]] scintigraphy (SRS) ([[octreotide]] scan)<ref name="pmid9274481">{{cite journal |vauthors=Cadiot G, Bonnaud G, Lebtahi R, Sarda L, Ruszniewski P, Le Guludec D, Mignon M |title=Usefulness of somatostatin receptor scintigraphy in the management of patients with Zollinger-Ellison syndrome. Groupe de Recherche et d'Etude du Syndrome de Zollinger-Ellison (GRESZE) |journal=Gut |volume=41 |issue=1 |pages=107–14 |year=1997 |pmid=9274481 |pmc=1027237 |doi= |url=}}</ref>
*[[Somatostatin receptor]] scintigraphy (SRS) using 111In-pentetreotide with single photon emission tomography ([[SPECT]]) scanning allows total body localization study simultaneously at one time which therefore allows the detection of liver and distant [[metastases]] and it is more sensitive in both localizing the primary [[gastrinoma]] and identifying patients with liver [[metastases]] than conventional methods such as [[CT]], [[MRI]] and [[ultrasound]]. <ref name="pmid8644985">{{cite journal| author=Gibril F, Reynolds JC, Doppman JL, Chen CC, Venzon DJ, Termanini B et al.| title=Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas. A prospective study. | journal=Ann Intern Med | year= 1996 | volume= 125 | issue= 1 | pages= 26-34 | pmid=8644985 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8644985  }} </ref>
*[[Somatostatin receptor]] scintigraphy (SRS) using 111In-pentetreotide with single photon emission tomography ([[SPECT]]) scanning allows total body localization study simultaneously at one time which therefore allows the detection of liver and distant [[metastases]] and it is more sensitive in both localizing the primary [[gastrinoma]] and identifying patients with liver [[metastases]] than conventional methods such as [[CT]], [[MRI]] and [[ultrasound]]. <ref name="pmid8644985">{{cite journal| author=Gibril F, Reynolds JC, Doppman JL, Chen CC, Venzon DJ, Termanini B et al.| title=Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas. A prospective study. | journal=Ann Intern Med | year= 1996 | volume= 125 | issue= 1 | pages= 26-34 | pmid=8644985 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8644985  }} </ref>
==Gallery==
[[File:ZES_SRS_1.jpg|thumb|none|350px| Figure 1, In-111 pentetreotide octreotide scan. Yang RH, Chu YK, CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0. <ref name="pmid27408649">{{cite journal| author=Yang RH, Chu YK| title=Zollinger-Ellison syndrome: Revelation of the gastrinoma triangle. | journal=Radiol Case Rep | year= 2015 | volume= 10 | issue= 1 | pages= 827 | pmid=27408649 | doi=10.2484/rcr.v10i1.827 | pmc=4921170 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27408649  }} </ref>]]
[[File:ZES_SRS_2.jpg|thumb|none|350px| Figure 2, Pentetreotide imaging plus abdomen scintigrams. Yang RH, Chu YK, CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0. <ref name="pmid27408649">{{cite journal| author=Yang RH, Chu YK| title=Zollinger-Ellison syndrome: Revelation of the gastrinoma triangle. | journal=Radiol Case Rep | year= 2015 | volume= 10 | issue= 1 | pages= 827 | pmid=27408649 | doi=10.2484/rcr.v10i1.827 | pmc=4921170 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27408649  }} </ref>]]
*'''Figure 1:''' An In-111 pentetreotide octreotide scan showed an avid focus at the epigastrium (open arrow), besides physiologic uptake in the kidneys and the spleen. <ref name="pmid27408649">{{cite journal| author=Yang RH, Chu YK| title=Zollinger-Ellison syndrome: Revelation of the gastrinoma triangle. | journal=Radiol Case Rep | year= 2015 | volume= 10 | issue= 1 | pages= 827 | pmid=27408649 | doi=10.2484/rcr.v10i1.827 | pmc=4921170 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27408649  }} </ref>
*'''Figure 2:''' Pentetreotide imaging plus abdomen scintigrams. The patient was asked to drink a mouthful of water with Tc-99m pertechnetate added. Dual-isotope planar images were acquired simultaneously, centering on the In-111 photopeaks and on the Tc-99m photopeak. <ref name="pmid27408649">{{cite journal| author=Yang RH, Chu YK| title=Zollinger-Ellison syndrome: Revelation of the gastrinoma triangle. | journal=Radiol Case Rep | year= 2015 | volume= 10 | issue= 1 | pages= 827 | pmid=27408649 | doi=10.2484/rcr.v10i1.827 | pmc=4921170 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27408649  }} </ref>
[[File:SRS1.jpg|thumb|none|350px|A, In-111 octreotide scan at 4hrs, Wosnitzer B, Gadiraju R, CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0, <ref name="pmid27307880">{{cite journal |vauthors=Wosnitzer B, Gadiraju R |title=The role of nuclear imaging in multiple endocrine neoplasia 1 (MEN 1) |journal=Radiol Case Rep |volume=5 |issue=4 |pages=452 |year=2010 |pmid=27307880 |pmc=4901017 |doi=10.2484/rcr.v5i4.452 |url=}}</ref>]]
[[File:SRS2.jpg|thumb|none|350px|B, In-111 octreotide scan at 24hrs , Wosnitzer B, Gadiraju R, CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0, <ref name="pmid27307880">{{cite journal |vauthors=Wosnitzer B, Gadiraju R |title=The role of nuclear imaging in multiple endocrine neoplasia 1 (MEN 1) |journal=Radiol Case Rep |volume=5 |issue=4 |pages=452 |year=2010 |pmid=27307880 |pmc=4901017 |doi=10.2484/rcr.v5i4.452 |url=}}</ref>]]
[[File:SRS3.jpg|thumb|none|350px|C, SPECT images at 24 hrs, Wosnitzer B, Gadiraju R, CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0, <ref name="pmid27307880">{{cite journal |vauthors=Wosnitzer B, Gadiraju R |title=The role of nuclear imaging in multiple endocrine neoplasia 1 (MEN 1) |journal=Radiol Case Rep |volume=5 |issue=4 |pages=452 |year=2010 |pmid=27307880 |pmc=4901017 |doi=10.2484/rcr.v5i4.452 |url=}}</ref>]]
[[File:SRS4.jpg|thumb|none|350px|D, SPECT images at 24 hrs, Wosnitzer B, Gadiraju R, CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0, <ref name="pmid27307880">{{cite journal |vauthors=Wosnitzer B, Gadiraju R |title=The role of nuclear imaging in multiple endocrine neoplasia 1 (MEN 1) |journal=Radiol Case Rep |volume=5 |issue=4 |pages=452 |year=2010 |pmid=27307880 |pmc=4901017 |doi=10.2484/rcr.v5i4.452 |url=}}</ref>]]
*'''Figures A-D:''' A 37-year-old male with MEN 1. The patient was injected with 6.4 mCi In-111 octreotide, and images were acquired in the anterior and posterior projections at 4 hours (A) and 24 hours (B). SPECT images were also obtained at 24 hours (C, axial, and D, coronal). Findings are consistent with metastatic somatostatin-receptor-positive malignancy involving the lymph nodes either in the peripancreatic or porta hepatis region.<ref name="pmid27307880">{{cite journal |vauthors=Wosnitzer B, Gadiraju R |title=The role of nuclear imaging in multiple endocrine neoplasia 1 (MEN 1) |journal=Radiol Case Rep |volume=5 |issue=4 |pages=452 |year=2010 |pmid=27307880 |pmc=4901017 |doi=10.2484/rcr.v5i4.452 |url=}}</ref>


==References==
==References==

Latest revision as of 16:26, 19 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Aravind Reddy Kothagadi M.B.B.S[3]

Overview

Endoscopic ultrasound and somatostatin receptor scintigraphy (SRS) (octreotide scan) may be helpful in the diagnosis of Zollinger-Ellison syndrome caused by gastrinoma.

Other Imaging Findings

Other imaging studies that may be helpful in the diagnosis of Zollinger-Ellison syndrome include: [1]

References

  1. Tang, Shou-jiang; Wu, Ruonan; Bhaijee, Feriyl (2014). "Zollinger–Ellison Syndrome". Video Journal and Encyclopedia of GI Endoscopy. 1 (3–4): 666–668. doi:10.1016/j.vjgien.2013.06.005. ISSN 2212-0971.
  2. Cadiot G, Bonnaud G, Lebtahi R, Sarda L, Ruszniewski P, Le Guludec D, Mignon M (1997). "Usefulness of somatostatin receptor scintigraphy in the management of patients with Zollinger-Ellison syndrome. Groupe de Recherche et d'Etude du Syndrome de Zollinger-Ellison (GRESZE)". Gut. 41 (1): 107–14. PMC 1027237. PMID 9274481.
  3. Gibril F, Reynolds JC, Doppman JL, Chen CC, Venzon DJ, Termanini B; et al. (1996). "Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas. A prospective study". Ann Intern Med. 125 (1): 26–34. PMID 8644985.

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