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| __NOTOC__ | | __NOTOC__ |
| {{Thyroid adenoma}} | | {{Thyroid adenoma}} |
| {{CMG}}; {{AE}} {{Ammu}} | | {{CMG}}; {{AE}} {{RAK}} |
| ==Overview== | | ==Overview== |
| Thyroid adenoma may be classified according to the histology into 3 subtypes/groups: follicular adenoma, papillary adenoma, and signet cell adenoma. | | Thyroid adenoma may be classified based on [[FNA]] [[cytology]] into 6 groups include macrofollicular, [[Adenomatoid tumor|adenomatoid]], colloid [[adenomas]], [[nodular]] [[goiter]], lymphocytic [[thyroiditis]] and [[granulomatous]] [[thyroiditis]]. |
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| ==Classification== | | ==Classification== |
| * Thyroid adenomas are classified into 2 subtype: [[Follicular thyroid adenoma|follicular adenoma]] and others. | | *Thyroid adenoma may be classified based on [[Fine needle aspiration]] (FNA) cytology into 6 groups (known as The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC)) :<ref name="pmid198888582">{{cite journal| author=Cibas ES, Ali SZ| title=The Bethesda System for Reporting Thyroid Cytopathology. | journal=Thyroid | year= 2009 | volume= 19 | issue= 11 | pages= 1159-65 | pmid=19888858 | doi=10.1089/thy.2009.0274 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19888858 }}</ref> |
| * Almost all [[thyroid]] adenomas are follicular adenomas.<ref name="isbn0-7216-0187-1">{{cite book |author=Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=1117 |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref> Others include papillary adenoma and signet cell adenoma which are very rare.<ref name="Kelley2008">[http://emedicine.medscape.com/article/850823-overview#aw2aab6b4 emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules] By Daniel J Kelley and Arlen D Meyers. Updated: Oct 17, 2008</ref>
| | ** Macrofollicular |
| * Follicular adenomas can be described as "cold", "warm", or "hot" depending on their level of function.<ref name="urlEndocrine Pathology">{{cite web |url=http://library.med.utah.edu/WebPath/ENDOHTML/ENDO037.html |title=Endocrine Pathology |format= |work= |accessdate=2009-05-08}}</ref>
| | ** [[Adenomatoid tumor|Adenomatoid]]/[[Hyperplasia|hyperplastic]] [[nodules]] |
| * [[Histopathological]]ly, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and [[colloid]] into the following types depicted in the flowchart. | | ** [[Colloid]] [[adenomas]] |
| * Below is a table with the description of different types of follicular adenoma: | | ** [[Nodular]] [[goiter]] |
| {| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
| | ** [[Lymphocytic thyroiditis]] |
| | valign="top" |
| | ** [[Granulomatous thyroiditis]] |
| |+
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| ! style="background: #4479BA; width: 50px;" | {{fontcolor|#FFF|Number}}
| | *For information on the classification of thyroid [[nodules]], [[Thyroid nodule classification|click here]]. |
| ! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Type of follicular adenoma}}
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| ! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Description}}
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| 1
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Microfollicular adenoma (fetal) | |
| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Consist of small, closely packed follicles | |
| * Have the potential for microinvasion | |
| |-
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| | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
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| 2
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Macrofollicular adenoma (colloid adenoma) | |
| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Consists of large amount of [[colloid]] | |
| * Do not have the potential for microinvasion | |
| |-
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| | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
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| 3
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Hürthle cell adenoma (oxyphil or oncocytic tumor) | |
| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Consists of oxyphil cells | |
| * Have the potential for microinvasion
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
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| 4
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Atypical embryonal adenoma
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Consists of embryonic cells
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| * Have the potential for microinvasion
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
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| 5
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Hyalinizing trabecular adenoma
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| | style="padding: 5px 5px; background: #F5F5F5;" |
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| * Consists of hyalinization
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| * Have the potential for microinvasion
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| |}
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| {{Familytree/start}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01= Thyroid adenoma}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | |,|-|-|-|v|-|-|-|v|-|-|-|^|-|-|-|v|-|-|-|.| | | | | | | | | | | | | | | | | |}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | B01 | | B02 | | B03 | | | | | | B04 | | B05 | | | | | | | | | | | | | | | | | | | |B01=Microfollicular adenoma (fetal adenoma)|B02=Macrofollicular adenoma (colloid adenoma)|B03=Hürthle cell adenoma (oxyphil or oncocytic tumor)|B04=Atypical embryonal adenoma|B05=Hyalinizing trabecular adenoma}}
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| {{Familytree/end}}
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| ==Reference== | | ==Reference== |