Extranodal NK-T-cell lymphoma causes: Difference between revisions

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__NOTOC__
__NOTOC__
{{Extranodal NK-T-cell lymphoma}}
{{Extranodal NK-T-cell lymphoma}}
{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{RG}}
==Overview==
==Overview==
There are no established causes for extranodal NK-T-cell lymphoma.
Extranodal NK/T-cell lymphoma is caused by transition mutation of [[p53]]. [[P53]] overexpresion has assosiation with poor prognosis.
==Causes==
==Causes==
There are no established causes for extranodal NK-T-cell lymphoma.
===Common Causes===
Common causes of extranodal NK-T cell lymphoma may include:<ref name="HarabuchiTakahara2019">{{cite journal|last1=Harabuchi|first1=Yasuaki|last2=Takahara|first2=Miki|last3=Kishibe|first3=Kan|last4=Nagato|first4=Toshihiro|last5=Kumai|first5=Takumi|title=Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress|journal=Frontiers in Pediatrics|volume=7|year=2019|issn=2296-2360|doi=10.3389/fped.2019.00141}}</ref>
 
*presence of Epstein-Barr virus ([[EBV]])-DNA and [[EBV]]-[[oncogenic]] proteins, and [[EBV]]
 
*transition mutation of [[p53]].
*[[P53]] overexertion association with poor prognosis.
 
=== Genetic causes: ===
* Extranodal NK/T-cell lymphoma is caused by transition [[mutation]] of [[p53]].<ref name="AozasaTakakuwa2008">{{cite journal|last1=Aozasa|first1=Katsuyuki|last2=Takakuwa|first2=Tetsuya|last3=Hongyo|first3=Tadashi|last4=Yang|first4=Woo-Ick|title=Nasal NK/T-cell lymphoma: epidemiology and pathogenesis|journal=International Journal of Hematology|volume=87|issue=2|year=2008|pages=110–117|issn=0925-5710|doi=10.1007/s12185-008-0021-7}}</ref>
* Genetic instability of micro satellites was not found in cases with the disease.<ref name="pmid8069852">{{cite journal| author=Greenblatt MS, Bennett WP, Hollstein M, Harris CC| title=Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. | journal=Cancer Res | year= 1994 | volume= 54 | issue= 18 | pages= 4855-78 | pmid=8069852 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8069852  }}</ref>
*[[P53]] overexertion has association with poor [[prognosis]].
 
===Causes by Organ System===
 
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| EBV infection
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| P53 mutation
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}
 
 
===Causes in Alphabetical Order===
List the causes of the disease in alphabetical order:
<div style="-moz-column-count:3; column-count:3;">
*[[EBV]] infection
*[[P53]] gene mutation
</div>


==References==
==References==
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Latest revision as of 13:21, 28 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

Extranodal NK/T-cell lymphoma is caused by transition mutation of p53. P53 overexpresion has assosiation with poor prognosis.

Causes

Common Causes

Common causes of extranodal NK-T cell lymphoma may include:[1]

  • transition mutation of p53.
  • P53 overexertion association with poor prognosis.

Genetic causes:

  • Extranodal NK/T-cell lymphoma is caused by transition mutation of p53.[2]
  • Genetic instability of micro satellites was not found in cases with the disease.[3]
  • P53 overexertion has association with poor prognosis.

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease EBV infection
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic P53 mutation
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes


Causes in Alphabetical Order

List the causes of the disease in alphabetical order:

  • EBV infection
  • P53 gene mutation

References

  1. ↑ Harabuchi, Yasuaki; Takahara, Miki; Kishibe, Kan; Nagato, Toshihiro; Kumai, Takumi (2019). "Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00141. ISSN 2296-2360.
  2. ↑ Aozasa, Katsuyuki; Takakuwa, Tetsuya; Hongyo, Tadashi; Yang, Woo-Ick (2008). "Nasal NK/T-cell lymphoma: epidemiology and pathogenesis". International Journal of Hematology. 87 (2): 110–117. doi:10.1007/s12185-008-0021-7. ISSN 0925-5710.
  3. ↑ Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994). "Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis". Cancer Res. 54 (18): 4855–78. PMID 8069852.


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