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{{Acute lymphoblastic leukemia}} | {{Acute lymphoblastic leukemia}} | ||
{{CMG}} {{AE}} {{RT}} | {{CMG}} {{AE}} {{RT}} {{CLG}} | ||
==Overview== | ==Overview== | ||
[[Bone]] [[X-ray]] in acute lymphoblastic leukemia is characterized by [[periosteal reaction]]. | |||
==X-ray== | ==X-ray== | ||
* [[Periosteal reaction]] | *An [[X-ray]] may be helpful in the [[diagnosis]] of acute lymphoblastic leukemia | ||
*Findings on an [[x-ray]] suggestive of acute lymphoblastic leukemia include [[periosteal reaction]]<ref name="pmid23329962">{{cite journal| author=Shahnazi M, Khatami A, Shamsian B, Haerizadeh B, Mehrafarin M| title=Bony lesions in pediatric acute leukemia: pictorial essay. | journal=Iran J Radiol | year= 2012 | volume= 9 | issue= 1 | pages= 50-6 | pmid=23329962 | doi=10.5812/iranjradiol.6765 | pmc=3522339 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23329962 }} </ref> | |||
*This radiographic feature is similar to that of [[osteosarcoma]]. | |||
*The following is also seen on [[bone]] [[x-rays]] in acute lymphoblastic leukemia:<ref name="pmid19621208">{{cite journal| author=Tafaghodi F, Aghighi Y, Rokni Yazdi H, Shakiba M, Adibi A| title=Predictive plain X-ray findings in distinguishing early stage acute lymphoblastic leukemia from juvenile idiopathic arthritis. | journal=Clin Rheumatol | year= 2009 | volume= 28 | issue= 11 | pages= 1253-8 | pmid=19621208 | doi=10.1007/s10067-009-1221-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19621208 }} </ref> | |||
**Radiolucent [[metaphyseal]] bands<ref name="pmid23407432">{{cite journal| author=Riccio I, Marcarelli M, Del Regno N, Fusco C, Di Martino M, Savarese R et al.| title=Musculoskeletal problems in pediatric acute leukemia. | journal=J Pediatr Orthop B | year= 2013 | volume= 22 | issue= 3 | pages= 264-9 | pmid=23407432 | doi=10.1097/BPB.0b013e32835d731c | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23407432 }} </ref> | |||
**Coarse trabeculation<ref name="NavarroMatcuk2017">{{cite journal|last1=Navarro|first1=Shannon M.|last2=Matcuk|first2=George R.|last3=Patel|first3=Dakshesh B.|last4=Skalski|first4=Matthew|last5=White|first5=Eric A.|last6=Tomasian|first6=Anderanik|last7=Schein|first7=Aaron J.|title=Musculoskeletal Imaging Findings of Hematologic Malignancies|journal=RadioGraphics|volume=37|issue=3|year=2017|pages=881–900|issn=0271-5333|doi=10.1148/rg.2017160133}}</ref> | |||
**[[Periosteal reaction|Periosteal reactions]]<ref name="AngsubhakornSuvannasankha2018">{{cite journal|last1=Angsubhakorn|first1=Natthapon|last2=Suvannasankha|first2=Attaya|title=Acute lymphoblastic leukaemia with osteolytic bone lesions: diagnostic dilemma|journal=BMJ Case Reports|year=2018|pages=bcr-2018-225008|issn=1757-790X|doi=10.1136/bcr-2018-225008}}</ref> | |||
**[[Osteopenia]]<ref name="pmid24986711">{{cite journal| author=Mostoufi-Moab S, Halton J| title=Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment. | journal=Curr Osteoporos Rep | year= 2014 | volume= 12 | issue= 3 | pages= 300-12 | pmid=24986711 | doi=10.1007/s11914-014-0222-3 | pmc=4131149 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24986711 }} </ref> | |||
<br style="clear:left" /> | |||
[[File:All5.png.001.png|400 px|thumb|Subtle, patchy sclerotic changes in the distal femoral and proximal tibial metaphyses[https://radiopaedia.org/cases/acute-lymphoblastic-leukaemia-1?lang=us Case courtesy of Dr Alexandra Stanislavsky, Radiopaedia.org, rID: 49049]|center]]<br style="clear:left" /> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category: | [[Category:Lymphocytic leukemia]] | ||
[[Category:Leukemia]] | |||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Hematology]] | |||
[[Category:Immunology]] | |||
Latest revision as of 16:03, 29 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]
Overview
Bone X-ray in acute lymphoblastic leukemia is characterized by periosteal reaction.
X-ray
- An X-ray may be helpful in the diagnosis of acute lymphoblastic leukemia
- Findings on an x-ray suggestive of acute lymphoblastic leukemia include periosteal reaction[1]
- This radiographic feature is similar to that of osteosarcoma.
- The following is also seen on bone x-rays in acute lymphoblastic leukemia:[2]
- Radiolucent metaphyseal bands[3]
- Coarse trabeculation[4]
- Periosteal reactions[5]
- Osteopenia[6]
References
- ↑ Shahnazi M, Khatami A, Shamsian B, Haerizadeh B, Mehrafarin M (2012). "Bony lesions in pediatric acute leukemia: pictorial essay". Iran J Radiol. 9 (1): 50–6. doi:10.5812/iranjradiol.6765. PMC 3522339. PMID 23329962.
- ↑ Tafaghodi F, Aghighi Y, Rokni Yazdi H, Shakiba M, Adibi A (2009). "Predictive plain X-ray findings in distinguishing early stage acute lymphoblastic leukemia from juvenile idiopathic arthritis". Clin Rheumatol. 28 (11): 1253–8. doi:10.1007/s10067-009-1221-0. PMID 19621208.
- ↑ Riccio I, Marcarelli M, Del Regno N, Fusco C, Di Martino M, Savarese R; et al. (2013). "Musculoskeletal problems in pediatric acute leukemia". J Pediatr Orthop B. 22 (3): 264–9. doi:10.1097/BPB.0b013e32835d731c. PMID 23407432.
- ↑ Angsubhakorn, Natthapon; Suvannasankha, Attaya (2018). "Acute lymphoblastic leukaemia with osteolytic bone lesions: diagnostic dilemma". BMJ Case Reports: bcr-2018–225008. doi:10.1136/bcr-2018-225008. ISSN 1757-790X.
- ↑ Mostoufi-Moab S, Halton J (2014). "Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment". Curr Osteoporos Rep. 12 (3): 300–12. doi:10.1007/s11914-014-0222-3. PMC 4131149. PMID 24986711.