Ameloblastoma causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Ameloblastoma}} | {{Ameloblastoma}} | ||
{{CMG}}{{AE}}{{Simrat}} | {{CMG}} ; {{AE}} {{VKG}}, {{Simrat}} | ||
==Overview== | ==Overview== | ||
There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of | There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of [[matrix]] metalloproteinase-2 which helps in inhibition of the local invasiveness of ameloblastoma, or it is may be due to increased expression of α5β1 [[integrin]] which participate in the local invasiveness of ameloblastoma. | ||
==Causes== | ==Causes== | ||
=== Common Causes === | |||
* | Common causes of ameloblastoma may include:<ref name="JeddyJeeva2013">{{cite journal|last1=Jeddy|first1=Nadeem|last2=Jeeva|first2=Sathiya|last3=Jeyapradha|first3=T|last4=Lakshmipathy|first4=P|last5=Saikrishna|first5=P|last6=Ananthalakshmi|first6=R|title=The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma|journal=Journal of Dr. NTR University of Health Sciences|volume=2|issue=3|year=2013|pages=157|issn=2277-8632|doi=10.4103/2277-8632.117179}}</ref><ref name="pmid26015700">{{cite journal |vauthors=Masthan KM, Anitha N, Krupaa J, Manikkam S |title=Ameloblastoma |journal=J Pharm Bioallied Sci |volume=7 |issue=Suppl 1 |pages=S167–70 |date=April 2015 |pmid=26015700 |pmc=4439660 |doi=10.4103/0975-7406.155891 |url=}}</ref> | ||
* | |||
* Decreased expression of of matrix [[metalloproteinase]]-2 | |||
* Increased expression α5β1 [[integrin]] | |||
=== Less Common Causes === | |||
Less common causes of ameloblastoma may include:<ref name="pmid26015700" /> | |||
* Mouth or jaw injury | |||
* [[Infection|Infections]] | |||
* [[Inflammation]] | |||
* Diet lacks in protein or minerals | |||
== Genetic Causes == | |||
* Ameloblastoma is caused by a [[mutation]] in the ''FGFR2-RAS-BRAF V600E'' gene.<ref name="pmid24993163">{{cite journal |vauthors=Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL |title=Activating FGFR2-RAS-BRAF mutations in ameloblastoma |journal=Clin. Cancer Res. |volume=20 |issue=21 |pages=5517–26 |date=November 2014 |pmid=24993163 |doi=10.1158/1078-0432.CCR-14-1069 |url=}}</ref><ref name="pmid24374844">{{cite journal |vauthors=Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K |title=High frequency of BRAF V600E mutations in ameloblastoma |journal=J. Pathol. |volume=232 |issue=5 |pages=492–8 |date=April 2014 |pmid=24374844 |pmc=4255689 |doi=10.1002/path.4317 |url=}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 17:31, 29 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2], Simrat Sarai, M.D. [3]
Overview
There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of ameloblastoma, or it is may be due to increased expression of α5β1 integrin which participate in the local invasiveness of ameloblastoma.
Causes
Common Causes
Common causes of ameloblastoma may include:[1][2]
- Decreased expression of of matrix metalloproteinase-2
- Increased expression α5β1 integrin
Less Common Causes
Less common causes of ameloblastoma may include:[2]
- Mouth or jaw injury
- Infections
- Inflammation
- Diet lacks in protein or minerals
Genetic Causes
References
- ↑ Jeddy, Nadeem; Jeeva, Sathiya; Jeyapradha, T; Lakshmipathy, P; Saikrishna, P; Ananthalakshmi, R (2013). "The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma". Journal of Dr. NTR University of Health Sciences. 2 (3): 157. doi:10.4103/2277-8632.117179. ISSN 2277-8632.
- ↑ 2.0 2.1 Masthan KM, Anitha N, Krupaa J, Manikkam S (April 2015). "Ameloblastoma". J Pharm Bioallied Sci. 7 (Suppl 1): S167–70. doi:10.4103/0975-7406.155891. PMC 4439660. PMID 26015700.
- ↑ Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL (November 2014). "Activating FGFR2-RAS-BRAF mutations in ameloblastoma". Clin. Cancer Res. 20 (21): 5517–26. doi:10.1158/1078-0432.CCR-14-1069. PMID 24993163.
- ↑ Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K (April 2014). "High frequency of BRAF V600E mutations in ameloblastoma". J. Pathol. 232 (5): 492–8. doi:10.1002/path.4317. PMC 4255689. PMID 24374844.