Follicular thyroid cancer pathophysiology: Difference between revisions

Jump to navigation Jump to search
 
(3 intermediate revisions by one other user not shown)
Line 16: Line 16:


==Genetics==
==Genetics==
* The [[ras|''Ras'' oncogene]] is positive in a significant proportion of individuals.  
* The [[ras|''Ras'' oncogene]] is positive in a significant proportion of individuals.<ref name="pmid123644662">{{cite journal |vauthors=Martelli ML, Iuliano R, Le Pera I, Sama' I, Monaco C, Cammarota S, Kroll T, Chiariotti L, Santoro M, Fusco A |title=Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue=10 |pages=4728–35 |date=October 2002 |pmid=12364466 |doi=10.1210/jc.2001-012054 |url=}}</ref>
*The [[ras|''Ras'' oncogene]] acts through the RAF-MEK-MAPK kinase pathway.
*The [[ras|''Ras'' oncogene]] acts through the RAF-MEK-MAPK kinase pathway.
* Other [[gene|genes]] involved in the [[pathogenesis]] of follicular thyroid cancer are:
* Other [[gene|genes]] involved in the [[pathogenesis]] of follicular thyroid cancer are:<ref name="pmid12866375">{{cite journal |vauthors=Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE |title=Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations |journal=Am. J. Clin. Pathol. |volume=120 |issue=1 |pages=71–7 |date=July 2003 |pmid=12866375 |doi=10.1309/ND8D-9LAJ-TRCT-G6QD |url=}}</ref>


:*''[[RET gene|RET]]/[[PTC]]'' ([[translocation]]) associated with [[Mitogen-activated protein kinase|MAPK]] and [[Phosphoinositide 3-kinase|PI3K]]-[[AKT]] signaling pathways.
:*''[[RET gene|RET]]/[[PTC]]'' ([[translocation]]) associated with [[Mitogen-activated protein kinase|MAPK]] and [[Phosphoinositide 3-kinase|PI3K]]-[[AKT]] signaling pathways.
Line 42: Line 42:
==Gross Pathology==
==Gross Pathology==
* Encapsulated tumors
* Encapsulated tumors
[[Image:Follicular adenoma of the thyroid.jpg|thumb|center|Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom).]]
[[File:Folladen.jpg|thumb|left|Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom).]]
<br style="clear:left">
 
==Microscopic Pathology==
==Microscopic Pathology==


* On [[Microscopy|microscopic examination]], [[Trabeculae|trabecular]], solid, [[Follicular cell|follicular]] [[Tumor cell|tumor cells]] that [[Invasion|invade]] [[capsule|tumor capsule]] or surrounding [[Vessels|vascular structures]] are found.
* On [[Microscopy|microscopic examination]], [[Trabeculae|trabecular]], solid, [[Follicular cell|follicular]] [[Tumor cell|tumor cells]] that [[Invasion|invade]] [[capsule|tumor capsule]] or surrounding [[Vessels|vascular structures]], are found.
<gallery>
<gallery>
Image:Metastatic follicular thyroid carcinoma - Case 264 (8558730243).jpg|Metastatic follicular thyroid carcinoma<ref>http://librepathology.org/wiki/index.php/File:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8558730243).jpg Accessed on October, 29 2015</ref>
Image:Metastatic follicular thyroid carcinoma - Case 264 (8558730243).jpg|Metastatic follicular thyroid carcinoma<ref>http://librepathology.org/wiki/index.php/File:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8558730243).jpg Accessed on October, 29 2015</ref>

Latest revision as of 17:48, 29 October 2019

Follicular thyroid cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Follicular thyroid cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

X-ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Follicular thyroid cancer pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Follicular thyroid cancer pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Follicular thyroid cancer pathophysiology

CDC on Follicular thyroid cancer pathophysiology

Follicular thyroid cancer pathophysiology in the news

Blogs on Follicular thyroid cancer pathophysiology

Directions to Hospitals Treating Follicular thyroid cancer

Risk calculators and risk factors for Follicular thyroid cancer pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Follicular thyroid cancer arises from follicular cells of thyroid, which are secretory cells that are normally involved in production and secretion of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Genes involved in the pathogenesis of follicular thyroid cancer include RAS, PAX8/PPARγ, and PTEN.

Pathogenesis

  • Follicular thyroid cancer is the second most common type of cancer. It constitutes about 15% of thyroid cancers.
Pathogenesis of follicular thyroid carcinoma





























Genetics

Schema of key pathways in the development and progression of thyroid cancer.

Associated Conditions

Gross Pathology

  • Encapsulated tumors
Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom).


Microscopic Pathology

Histopathological Video

Video

{{#ev:youtube|3_eCHeOkdgg}}

References

  1. Aytug, Serhat (June 13, 2006). "Hurthle Cell Carcinoma". eMedicine. Check date values in: |date= (help)
  2. Martelli ML, Iuliano R, Le Pera I, Sama' I, Monaco C, Cammarota S, Kroll T, Chiariotti L, Santoro M, Fusco A (October 2002). "Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth". J. Clin. Endocrinol. Metab. 87 (10): 4728–35. doi:10.1210/jc.2001-012054. PMID 12364466.
  3. Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE (July 2003). "Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations". Am. J. Clin. Pathol. 120 (1): 71–7. doi:10.1309/ND8D-9LAJ-TRCT-G6QD. PMID 12866375.
  4. http://librepathology.org/wiki/index.php/File:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8558730243).jpg Accessed on October, 29 2015
  5. http://librepathology.org/wiki/index.php/File:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8559837390).jpg Accessed on October, 29 2015