Cardiac amyloidosis nuclear cardiac scans: Difference between revisions
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==Overview== | ==Overview== | ||
The initial imaging modality imaging in patients with suspected cardiac amyloidosis is echocardiography. The diagnosis of ATTR cardiac amyloid can then be confirmed with a nuclear scan (99mTc-PYP imaging), which can then guide management.<ref>{{Cite journal|last=Falk|first=RH|date=May 2014|title=How to image cardiac amyloidosis|url=https://www.ahajournals.org/doi/full/10.1161/CIRCIMAGING.113.001396?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed|journal=Circulation: Cardiovascular Imaging|volume=7|pages=552-562|via=}}</ref> | The initial imaging modality imaging in patients with suspected cardiac amyloidosis is [[Cardiac amyloidosis echocardiography|echocardiography]]. The diagnosis of ATTR cardiac amyloid can then be confirmed with a nuclear scan (99mTc-PYP imaging), which can then guide management.<ref>{{Cite journal|last=Falk|first=RH|date=May 2014|title=How to image cardiac amyloidosis|url=https://www.ahajournals.org/doi/full/10.1161/CIRCIMAGING.113.001396?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed|journal=Circulation: Cardiovascular Imaging|volume=7|pages=552-562|via=}}</ref> | ||
==Nuclear Cardiac Scans== | ==Nuclear Cardiac Scans== | ||
Latest revision as of 22:08, 29 October 2019
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Cardiac amyloidosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Cardiac amyloidosis nuclear cardiac scans On the Web |
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American Roentgen Ray Society Images of Cardiac amyloidosis nuclear cardiac scans |
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Risk calculators and risk factors for Cardiac amyloidosis nuclear cardiac scans |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Aarti Narayan, M.B.B.S [3]
Overview
The initial imaging modality imaging in patients with suspected cardiac amyloidosis is echocardiography. The diagnosis of ATTR cardiac amyloid can then be confirmed with a nuclear scan (99mTc-PYP imaging), which can then guide management.[1]
Nuclear Cardiac Scans
99mTechnetium-pyrophopshate (99mTc-PYP) is a widely available radiotracer. In conjunction with a cardiac or chest SPECT, 99mTc-PYP is infused and then the images are examined for visual interpretation and quantification of the degree of myocardial uptake. Qualitatively, myocardial uptake patterns are either absent, focal, diffuse, or focal on diffuse. A diffuse pattern is suggestive of ATTR cardiac amyloid. Quantitatively, radiotracer uptake in the the region of interest (ROI) in the heart (H) is compared to uptake in the contralateral lung (CL) at 1 hour after tracer injection, which yields an H/CL ratio. A ratio of ≥1.5 is suggestive of ATTR cardiac amyloid. Alternatively, uptake in the ROI can be visually compared to the rib at 3 hours after tracer injection, with a visual score grade of >2 (indicating uptake equal to that of the rib) suggestive of ATTR cardiac amyloid.[2]
References
- ↑ Falk, RH (May 2014). "How to image cardiac amyloidosis". Circulation: Cardiovascular Imaging. 7: 552–562.
- ↑ "ASNC Practice Points: 99mTechnetium-Pyrophosphate Imaging for Transthyretin Cardiac Amyloidosis" (PDF).