Meningioma: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
Jinhui Wu (talk | contribs)
3,964 edits
No edit summary
 
Ifeoma odukwe (talk | contribs)
2,699 edits
No edit summary
 
(14 intermediate revisions by 7 users not shown)
Line 1: Line 1:
__NOTOC__
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{Infobox_Disease |
{{Meningioma}}
  Name          = {{PAGENAME}} |
{{CMG}} {{AE}}{{IO}}{{HL}}
  Image          = Contrast enhanced meningioma.jpg |
  Caption        = |
  DiseasesDB    = 8008 |
  ICD10          = C70, D32 |
  ICD9          = {{ICD9|225.2}} |
  ICDO          = 9530  |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = neuro |
  eMedicineTopic = 209 |
  eMedicine_mult = {{eMedicine2|radio|439}} |
  MeshID        = D008579 |
}}
{{Search infobox}}
{{CMG}}


{{Editor Help}}
{{SK}} Meningioma, Arachnoidal fibroblastoma, Dural endothelioma, Leptomeningioma, Meningeal fibroblastoma


==Overview==
==[[Meningioma overview|Overview]]==
'''Meningiomas''' are the most common [[benign]] [[tumor]]s of the [[brain]] (95% of benign tumors). However they can also be [[malignant]]. They arise from the arachnoidal cap cells of the [[meninges]] and represent about 15% of all primary brain tumors. They are more common in [[female]]s than in [[male]]s (2:1) and have a peak incidence in the sixth and seventh decades. Most cases are sporadic while some are familial. There has been some evidence that persons who have undergone [[radiation]] to the [[scalp]] are more at risk for developing meningiomas. The most frequent genetic mutations involved in meningiomas are inactivation mutations in the neurofibromatosis 2 [[gene]] (merlin) on [[chromosome]] 22q.


==Pathogenesis==
==[[Meningioma historical perspective|Historical Perspective]]==
Meningiomas arise from arachnoidal cells, most of which are near the vicinity of the venous sinuses, and this is the site of greatest prevalence for meningioma formation. They are most frequently attached to the dura over the superior parasagittal surface of frontal and parietal lobes, along the sphenoid ridge, in the [[olfactory]] grooves, the sylvian region, superior [[cerebellum]] along the ''[[falx cerebri]]'', [[cerebellopontine angle]], and the [[spinal cord]]. The tumor is usually gray, well-circumscribed, and takes on the form of space it occupies. They are usually dome-shaped, with the base lying on the [[dura]].


Histologically, the cells are relatively uniform, with a tendency to encircle one another, forming whorls and [[psammoma body|psammoma bodies]] (laminated calcific concretions). They have a tendency to calcify and are highly vascularized.
==[[Meningioma classification|Classification]]==


==Clinical manifestations==
 
{{main|brain tumor}}
==[[Meningioma pathophysiology|Pathophysiology]]==
Small tumors (e.g., < 2.0 cm) are usually incidental findings at [[autopsy]] without having caused [[symptom]]s. Larger tumors can cause symptoms depending on the size and location.
 
*''[[Focal seizures]]'' may be caused by meningiomas that overlie the cerebrum
==[[Meningioma causes|Causes]]==
*''Progressive spastic weakness in legs'' and ''incontinence'' may be caused by tumors that overlie the parasagittal frontoparietal region.
 
*''Sylvian tumors'' may cause a myriad of motor, sensory, aphasic, and seizure symptoms depending on the location.
==[[Meningioma differential diagnosis|Differentiating Meningioma from other Diseases]]==
*''[[intracranial pressure#Increased ICP|Increased intracranial pressure]]'' eventually occurs, but is less frequent than in [[glioma]]s.
 
==[[Meningioma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Meningioma risk factors|Risk Factors]]==
 
==[[Meningioma screening|Screening]]==
 
 
==[[Meningioma natural history|Natural History, Complications and Prognosis]]==


==Diagnosis==
==Diagnosis==
Meningiomas are readily visualized with contrast [[CT]], [[MRI]] with gadolinium, and arteriography, all attributed to the fact that meningiomas are extra axial and vascularized. CSF protein is usually elevated if [[lumbar puncture]] is attempted.
[[Meningioma staging|Staging]] | [[Meningioma history and symptoms|History and Symptoms]] | [[Meningioma physical examination|Physical Examination]] | [[Meningioma laboratory tests|Laboratory Findings]] | [[Meningioma X Ray|X Ray]] | [[Meningioma CT|CT]] | [[Meningioma MRI|MRI]] | [[Meningioma other imaging findings|Other Imaging Findings]] | [[Meningioma other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
*'''''Surgical resection''''' -- Meningiomas can usually be surgically resected with permanent cure if the tumor is superficial on the dural surface and easily accessible. Transarterial [[embolization]] has become a standard preoperative procedure in the preoperative management. [http://www.aans.org/education/journal/neurosurgical/july03/15-1-10.pdf] For incompletely accessible tumors, recurrence is likely. These regions include the medial [[sphenoid bone]], parasellar region, or anterior brainstem. If invasion of the adjacent bone occurs, total removal is nearly impossible. [[Malignant]] transformation is rare.
[[Meningioma medical therapy|Medical Therapy]] | [[Meningioma surgery|Surgery]] | [[Meningioma primary prevention|Primary Prevention]] | [[Meningioma secondary prevention|Secondary Prevention]] | [[Meningioma cost-effectiveness of therapy]] | [[Meningioma future or investigational therapies|Future or Investigational therapies]]
 
==Case Studies==
*'''''Radiation therapy''''', including [[Gamma Knife]] or proton beam treatment, may be pursued in cases of inoperable or unresectable tumors, or if tumor shows malignant transformation. Focused radiation may also be helpful for small tumors at the base of the skull.
[[Meningioma case study one|Case #1]]


*'''''Conventional chemotherapy''''' is likely not effective. Antiprogestin agents have been used, but with variable results. Recent evidence that [[hydroxyurea]] has the capacity to shrink unresectable or recurrent meningiomas is being further evaluated.


==See also==
==Related chapters==
* [[Sphenoid wing meningioma]]
* [[Sphenoid wing meningioma]]
* [[Optic nerve sheath meningioma]]
* [[Optic nerve sheath meningioma]]


==External links==
 
* [http://www.mayoclinic.com/health/meningioma/DS00901 Meningioma information] from the [[Mayo Clinic]]
* [http://www.meningiomamommas.org Meningioma Mommas - An online support group for all those (both women and men) affected by meningioma brain tumors]
* [http://rad.usuhs.edu/medpix/medpix.html?mode=image_finder&srchstr=meningioma&srch_type=all&action=search#top Images of meningiomas] from MedPix
* [http://www.brighamandwomens.org/neurosurgery/meningioma/meningiomafacts.asp Brigham and Woman's Hospital]
* [http://www.cancerbackup.org.uk/Cancertype/Brain/Typesofbraintumour/Meningioma CancerBackup]
* [http://www.meningiomauk.org/ Meningioma UK Support]
* [http://www.gamma-knife-surgery.com/gammaKnife/meningiomas.asp Gamma Knife Video]


{{Nervous tissue tumors}}
{{Nervous tissue tumors}}
{{SIB}}
[[Category:Neurological disorders]]
[[Category:Neurosurgery]]
[[Category:Types of cancer]]
[[Category:Oncology]]


[[da:Meningeom]]
[[da:Meningeom]]
Line 79: Line 58:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Neurological disorders]]
[[Category:Neurosurgery]]
[[Category:Neurology]]
[[Category:Oncology]]
[[Category:Mature chapter]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Neurology]]
[[Category:Neurosurgery]]

Latest revision as of 15:43, 7 November 2019

For patient information click here

Meningioma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Meningioma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Meningioma On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Meningioma

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Meningioma

CDC on Meningioma

Meningioma in the news

Blogs on Meningioma

Directions to Hospitals Treating Meningioma

Risk calculators and risk factors for Meningioma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2]Haytham Allaham, M.D. [3]

Synonyms and keywords: Meningioma, Arachnoidal fibroblastoma, Dural endothelioma, Leptomeningioma, Meningeal fibroblastoma

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Meningioma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Meningioma cost-effectiveness of therapy | Future or Investigational therapies

Case Studies

Case #1


Related chapters


Template:Nervous tissue tumors

da:Meningeom de:Meningeom it:Meningioma he:מנינגיומה nl:Meningeoom fi:Meningeooma


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Meningioma&oldid=1588408"