Hypogonadism causes: Difference between revisions

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__NOTOC__
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{{Hypogonadism}}
{{Hypogonadism}}
{{CMG}}
{{CMG}} {{AE}} {{ADI}} {{LRO}}
==Overview==
==Overview==
==Causes==
Hypogonadism is commonly caused by [[congenital]], acquired [[genetic]] and [[endocrinology|endocrinological]] conditions. Life threatening causes may include malignancies and must take in to consideration during patient approach.<ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref><ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>
===Causes in Alphabetical Order <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>===
 
==== Primary Testicular Failure ====
==Causes ==
* [[Anorchidism]]
<div style="-webkit-user-select: none;">
===Life Threatening Causes===
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. The following diseases are life threatening causes of hypogonadism:
*[[Astrocytoma]]
*[[Chronic renal failure]]
*[[Renal cell carcinoma|Papillary renal cell carcinoma]] 
*Postinfectious lesions of the [[CNS|central nervous system (CNS)]]
*Ureter cancer 
*Urinary system cancer 
*[[Wilms tumor ]]
*[[Infective endocarditis]]
===Common Causes===
*[[Anorchidism]]
*[[Chemotherapy]]
*[[Cryptorchidism]]
*[[FSH]] beta subunit mutation (follicle stimulating hormone)
*[[FSH]] receptor mutation
*[[Klinefelter Syndrome]]
*[[LH]] (luteinizing hormone) beta subunit mutation
*[[LH]] receptor mutation
*[[LH]] resistance
*[[Radiation therapy]]
*[[Sertoli-cell]]-only syndrome
*[[Testicular]] biosynthetic defects
* [[Autoimmune]] [[oophoritis]]
* [[Chemotherapy]]
* [[Chemotherapy]]
* [[Cryptorchidism]]
* Familial and sporadic XX gonadal [[dysgenesis]] and its variants
* [[FSH]] beta subunit mutation (follicle stimulating hormone)
* [[FSH]] receptor mutation
* [[Klinefelter Syndrome]]
* [[LH]] (luteinizing hormone) beta subunit mutation
* [[LH]] receptor mutation
* [[LH]] resistance
* [[Radiation therapy]]
* [[Sertoli-cell]]-only syndrome
* Testicular biosynthetic defects
 
==== Primary Ovarian Failure ====
* Autoimmune oophoritis
* Chemotherapy
* Familial and sporadic XX gonadal dysgenesis and its variants
* Familial and sporadic XY gonadal dysgenesis and its variants
* Familial and sporadic XY gonadal dysgenesis and its variants
* [[FSH]] beta subunit mutation (follicle stimulating hormone)  
* [[FSH]] beta subunit mutation (follicle stimulating hormone)  
* [[FSH]] receptor mutation
* [[FSH]] receptor mutation
* Galactosemia
* [[Galactosemia]]
* Glycoprotein syndrome type 1
* [[Glycoprotein]] syndrome type 1
* LH (luteinizing hormone) beta subunit mutation
* LH (luteinizing hormone) beta subunit mutation
* LH/[[Ddx:Human Chorionic Gonadotropin|human chorionic gonadotropin]] resistance
* LH/[[Ddx:Human Chorionic Gonadotropin|human chorionic gonadotropin]] resistance
Line 35: Line 45:
* [[Polycystic ovarian disease]]
* [[Polycystic ovarian disease]]
* [[Radiation therapy]]
* [[Radiation therapy]]
* Resistant ovary  
* Resistant [[ovary]]
* [[Turner Syndrome]]
* [[Turner Syndrome]]
==== Secondary Hypogonadism ====
* [[Astrocytoma]]
* [[Astrocytoma]]
* [[Bardet-Biedl Syndrome]]
* [[Bardet-Biedl Syndrome]]
* Congenital adrenal hypoplasia
* Congenital adrenal hypoplasia
* Congenital hypogonadotropic hypogonadism
* Congenital hypogonadotropic hypogonadism
* Craniofacial anomalies
* [[Craniofacial]] anomalies
* [[Craniopharyngioma]]
* [[Craniopharyngioma]]
* Exercise-induced amenorrhea
* Exercise-induced amenorrhea
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* Radiation therapy
* Radiation therapy
* Vascular abnormalities of the CNS
* Vascular abnormalities of the CNS
===Causes by Organ System===
{| style="width:80%; height:100px" border="1"
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" | [[Alström syndrome]],  [[Amyloidosis]],  [[Cardiofaciocutaneous syndrome]],  [[Vascular abnormalities of the cns]]
|-
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
| bgcolor="Beige" | [[Alcohol]],  [[Alkylating agents]],  [[Cytotoxic therapeutic agents]],  [[Environmental toxins]],  [[Ethanol]],  [[Toxins]]
|-
|- bgcolor="LightSteelBlue"
| '''Dental'''
| bgcolor="Beige" | [[Jaffe-campanacci syndrome]],  [[Lepromatous leprosy]]
|-
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| bgcolor="Beige" | [[Antiandrogens]],  [[Ketoconazole]],  [[Marijuana use]],  [[Opioids]]
|-
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| bgcolor="Beige" | [[Adiposogenital dystrophy]],  [[Adrenal hypoplasia]],  [[Autoimmune polyendocrine syndrome type 2]],  [[Combined pituitary hormone deficiency ]] ,  [[Disorders of androgen synthesis]],  [[Functional gonadotropin deficiency]],  [[Glucocorticoids]],  [[Glycoprotein syndrome type 1]],  [[Gonadal dysgenesis ]] ,  [[Growth hormone secreting pituitary adenoma]],  [[Hyperprolactinemia]],  [[Hypogonadic hypogonadism]],  [[Hypopituitarism]],  [[Hypothalamic glioma]],  [[Panhypopituitarism]],  [[Pituitary tumor]],  [[Poems syndrome]],  [[Polycystic ovarian disease]],  [[Proprotein convertase 1/3 deficiency]],  [[Pseudohypoparathyroidism type 1a]],  [[Swyer's syndrome]],  [[Testicular biosynthetic defects]]
|-
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| bgcolor="Beige" | [[Hepatic cirrhosis]]
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| bgcolor="Beige" | [[17α-hydroxylase deficiency]],  [[17β-hydroxysteroid dehydrogenase iii deficiency]],  [[20-lyase deficiency]],  [[48, xxxy aneuploidy]],  [[48, xxyy aneuploidy]],  [[4h syndrome]],  [[Acrocephalopolysyndactyly type 2]],  [[Alström syndrome]],  [[Aromatase deficiency]],  [[Autoimmune oophoritis]],  [[Bardet-biedl syndrome]],  [[Belgian type mental retardation]],  [[Blepharophimosis syndrome]],  [[Borjeson-forssman-lehmann syndrome]],  [[Boucher-neuhäuser syndrome]],  [[Cardiofaciocutaneous syndrome]],  [[Ccfdn syndrome]],  [[Charge syndrome]],  [[Congenital adrenal hypoplasia]],  [[Craniofacial anomalies]],  [[Craniopharyngioma]],  [[Cryptorchidism]],  [[Didmoad syndrome]],  [[Dystrophia myotonica type 2]],  [[Fsh receptor deficiency]],  [[Fsh beta subunit mutation (follicle stimulating hormone)]],  [[Fsh receptor mutation]],  [[Galactose-1-phosphate uridyltransferase deficiency]],  [[Galactosemia]],  [[Gaucher disease]],  [[Gordon holmes syndrome]],  [[Hartsfield syndrome]],  [[Image syndrome]],  [[Isolated fsh deficiency]],  [[Isolated lh deficiency]],  [[Jaffe-campanacci syndrome]],  [[Kallmann syndrome]],  [[Klinefelter syndrome]],  [[Laurence-moon syndrome]],  [[Leptin deficiency]],  [[Lh (luteinizing hormone) beta subunit mutation]],  [[Lh receptor mutation]],  [[Lh resistance]],  [[Lipoid congenital adrenal hyperplasia]],  [[Malouf syndrome]],  [[Marinesco-sjogren-garland syndrome]],  [[Martsolf syndrome]],  [[Mobius syndrome]],  [[Mosaicism]],  [[Myotonic dystrophy]],  [[Noonan syndrome]],  [[Prader-willi syndrome]],  [[Proprotein convertase 1/3 deficiency]],  [[Resistant ovary]],  [[Rud syndrome]],  [[Sertoli-cell-only syndrome]],  [[Turner syndrome]],  [[Woodhouse-sakati syndrome]],  [[X-linked mental retardation-hypotonic facies syndrome]],  [[Xx gonadal dysgenesis]]
|-
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| bgcolor="Beige" | [[Glycoprotein syndrome type 1]],  [[Hemochromatosis]],  [[Langerhans histiocytosis]],  [[Leukoencephalopathy ]] ,  [[Zinc deficiency]]
|-
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| bgcolor="Beige" | [[Chemotherapy]],  [[Opioids]],  [[Orchitis]],  [[Radiation therapy]],  [[Surgery]]
|-
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| bgcolor="Beige" | [[Aids]],  [[Infections]],  [[Mumps]]
|-
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| bgcolor="Beige" | [[Astrocytoma]],  [[Belgian type mental retardation]],  [[Craniopharyngioma]],  [[Gordon holmes syndrome]],  [[Poems syndrome]],  [[Postinfectious lesions of the central nervous system (cns)]],  [[Vascular abnormalities of the cns]]
|-
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| bgcolor="Beige" | [[Zinc deficiency]]
|-
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| bgcolor="Beige" | [[Exercise-induced amenorrhea]],  [[Ovarian resistance syndrome]],  [[Ovarian torsion]],  [[Polycystic ovarian disease]],  [[Premature ovarian failure]],  [[Premature menopause]],  [[Resistant ovary]],  [[Rud syndrome]],  [[Suramin]],  [[Swyer's syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| bgcolor="Beige" | [[Astrocytoma]],  [[Germinoma]],  [[Growth hormone secreting pituitary adenoma]],  [[Hypothalamic glioma]],  [[Langerhans histiocytosis]],  [[Optic glioma]],  [[Other germ cell tumors]],  [[Pituitary tumor]]
|-
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| bgcolor="Beige" | [[Optic glioma]]
|-
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| bgcolor="Beige" | [[Alcohol]]
|-
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| bgcolor="Beige" | [[Anorexia nervosa]]
|-
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| bgcolor="Beige" | [[Chronic renal failure]],  [[Renal failure]]
|-
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| bgcolor="Beige" | [[Amyloidosis]],  [[Autoimmune damage]],  [[Autoimmunity]],  [[Chronic systemic illnesses]],  [[Lepromatous leprosy]]
|-
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| bgcolor="Beige" | [[Aids]],  [[Epididymo-orchitis]],  [[Germinoma]],  [[Orchidectomy]],  [[Suramin]]
|-
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| bgcolor="Beige" | [[Head trauma]],  [[Hepatic cirrhosis]],  [[Ovarian torsion]],  [[Testicular torsion]],  [[Trauma]]
|-
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| bgcolor="Beige" | [[Anorchia]],  [[Anorchidism]],  [[Congenital hypogonadotropic hypogonadism]],  [[Cryptorchidism]],  [[Disorders of androgen synthesis]],  [[Epididymo-orchitis]],  [[Gonadal dysgenesis ]] ,  [[Hypogonadic hypogonadism]],  [[Orchitis]],  [[Testicular torsion]],  [[Varicocele]]
|-
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| bgcolor="Beige" | No underlying causes
|-
|}
===Causes in Alphabetical Order===
{{columns-list|
*[[17α-hydroxylase deficiency]]
*[[17β-hydroxysteroid dehydrogenase iii deficiency]]
*[[20-lyase deficiency]]
*[[48, xxxy aneuploidy]]
*[[48, xxyy aneuploidy]]
*[[4h syndrome]]
*[[Acrocephalopolysyndactyly type 2]]
*[[Adiposogenital dystrophy]]
*[[Adrenal hypoplasia]]
*[[Aids]]
*[[Alcohol]]
*[[Alkylating agents]]
*[[Alström syndrome]]
*[[Amyloidosis]]
*[[Anorchia]]
*[[Anorchidism]]
*[[Anorexia nervosa]]
*[[Antiandrogens]]
*[[Aromatase deficiency]]
*[[Astrocytoma]]
*[[Autoimmune damage]]
*[[Autoimmune oophoritis]]
*[[Autoimmune polyendocrine syndrome type 2]]
*[[Autoimmunity]]
*[[Bardet-biedl syndrome]]
*[[Belgian type mental retardation]]
*[[Blepharophimosis syndrome]]
*[[Borjeson-forssman-lehmann syndrome]]
*[[Boucher-neuhäuser syndrome]]
*[[Cardiofaciocutaneous syndrome]]
*[[Ccfdn syndrome]]
*[[Charge syndrome]]
*[[Chemotherapy]]
*[[Chronic renal failure]]
*[[Chronic systemic illnesses]]
*[[Combined pituitary hormone deficiency ]]
*[[Congenital adrenal hypoplasia]]
*[[Congenital hypogonadotropic hypogonadism]]
*[[Craniofacial anomalies]]
*[[Craniopharyngioma]]
*[[Cryptorchism]]
*[[Cytotoxic therapeutic agents]]
*[[Didmoad syndrome]]
*[[Disorders of androgen synthesis]]
*[[Dystrophia myotonica type 2]]
*[[Environmental toxins]]
*[[Epididymo-orchitis]]
*[[Ethanol]]
*[[Exercise-induced amenorrhea]]
*[[Fsh receptor deficiency]]
*[[Fsh beta subunit mutation (follicle stimulating hormone)]]
*[[Fsh receptor mutation]]
*[[Functional gonadotropin deficiency]]
*[[Galactose-1-phosphate uridyltransferase deficiency]]
*[[Galactosemia]]
*[[Gaucher disease]]
*[[Germinoma]]
*[[Glucocorticoids]]
*[[Glycoprotein syndrome type 1]]
*[[Gonadal dysgenesis ]]
*[[Gordon holmes syndrome]]
*[[Growth hormone secreting pituitary adenoma]]
*[[Hartsfield syndrome]]
*[[Head trauma]]
*[[Hemochromatosis]]
*[[Hepatic cirrhosis]]
*[[Hyperprolactinemia]]
*[[Hypogonadic hypogonadism]]
*[[Hypogonadotrophic hypogonadism]]
*[[Hypopituitarism]]
*[[Hypothalamic glioma]]
*[[Idiopathic]]
*[[Image syndrome]]
*[[Infections]]
*[[Isolated fsh deficiency]]
*[[Isolated lh deficiency]]
*[[Jaffe-campanacci syndrome]]
*[[Kallmann syndrome]]
*[[Ketoconazole]]
*[[Klinefelter syndrome]]
*[[Langerhans histiocytosis]]
*[[Laurence-moon syndrome]]
*[[Lepromatous leprosy]]
*[[Leptin deficiency]]
*[[Leukoencephalopathy ]]
*[[Lh (luteinizing hormone) beta subunit mutation]]
*[[Lh receptor mutation]]
*[[Lh resistance]]
*[[Lipoid congenital adrenal hyperplasia]]
*[[Malouf syndrome]]
*[[Marijuana use]]
*[[Marinesco-sjogren-garland syndrome]]
*[[Martsolf syndrome]]
*[[Mobius syndrome]]
*[[Mosaicism]]
*[[Mumps]]
*[[Myotonic dystrophy]]
*[[Noonan syndrome]]
*[[Opioids]]
*[[Optic glioma]]
*[[Orchidectomy]]
*[[Orchitis]]
*[[Other germ cell tumors]]
*[[Ovarian resistance syndrome]]
*[[Ovarian torsion]]
*[[Panhypopituitarism]]
*[[Pituitary tumor]]
*[[Poems syndrome]]
*[[Polycystic ovarian disease]]
*[[Postinfectious lesions of the central nervous system (cns)]]
*[[Prader-willi syndrome]]
*[[Premature ovarian failure]]
*[[Premature menopause]]
*[[Proprotein convertase 1/3 deficiency]]
*[[Pseudohypoparathyroidism type 1a]]
*[[Radiation therapy]]
*[[Radiotherapy]]
*[[Renal failure]]
*[[Resistant ovary]]
*[[Rud syndrome]]
*[[Sertoli-cell-only syndrome]]
*[[Suramin]]
*[[Surgery]]
*[[Swyer's syndrome]]
*[[Testicular biosynthetic defects]]
*[[Testicular torsion]]
*[[Toxins]]
*[[Trauma]]
*[[Turner syndrome]]
*[[Varicocele]]
*[[Vascular abnormalities of the cns]]
*[[Woodhouse-sakati syndrome]]
*[[X-linked mental retardation-hypotonic facies syndrome]]
*[[Xx gonadal dysgenesis]]
*[[Zinc deficiency]]
*[[Hemophilia ]]
*[[Henoch-schonlein purpura ]]
*[[Hepatitis a ]]
*[[Hepatitis b ]]
*[[Hepatitis c ]]
*[[Hepatorenal tyrosinemia]]
*[[Hereditary hemorrhagic telangiectasia ]]
*[[Hereditary leiomyomatosis ]]
*[[Herns syndrome ]]
*[[Honeymoon bladder ]]
*[[Hypercalciuria]]
*[[Hypertension ]]
*[[Hypocomplementemic urticarial vasculitis]]
*[[Idarubicin]]
*[[Iga nephropathy ]]
*[[Immune thrombocytopenic purpura ]]
*[[Indandione rodenticide poisoning ]]
*[[Infective endocarditis]]
*[[Interstitial nephritis ]]
*[[Jaundice ]]
*[[Juniper tar poisoning ]]
*[[Kidney cancer ]]
*[[Kidney stones ]]
*[[Klerat rodenticide poisoning ]]
*[[Lactate dehydrogenase deficiency ]]
*[[Lecithin-cholesterol acyltransferase deficiency]]
*[[Leiomyomatosis of esophagus]]
*[[Leucinosis ]]
*[[Leukocytoclastic angiitis ]]
*[[Liver cancer ]]
*[[Machupo virus ]]
*[[Malaria ]]
*[[Malignant rhabdoid tumors ]]
*[[Maple syrup urine disease]]
*[[Matikus rodenticide poisoning ]]
*[[Medullary sponge kidney ]]
*[[Meier-blumberg-imahorn syndrome ]]
*[[Melanoma]]
*[[Membranous nephropathy]]
*[[Mepacrine]]
*[[Methaemoglobinaemia]]
*[[Metronidazole]]
*[[Milky urine]]
*[[Mitoxantrone]]
*[[Monosodium methanarsenate ]]
*[[Mouser rodenticide poisoninge]]
*[[Myoglobinuria]]
*[[Nail-patella syndrome ]]
*[[Naked brimcap poisoning ]]
*[[Naphthalene ]]
*[[Nefopam]]
*[[Neoplastic porphyria tarda ]]
*[[Nephritis ]]
*[[Nephrocalcinosis ]]
*[[Nephropathy]]
*[[Nephrosis ]]
*[[Nitrates ]]
*[[Norum disease]]
*[[Obstructive jaundice]]
*[[Oncocytoma]]
*[[Oral contraceptives]]
*[[Orchitis ]]
*[[Oxalosis ]]
*[[Oxamniquine]]
*[[Papillary renal cell carcinoma ]]
*[[Paragonimiases ]]
*[[Parkinson's disease]]
*[[Pelvic fracture ]]
*[[Pelvic lipomatosis ]]
*[[Penis cancer ]]
*[[Penis conditions ]]
*[[Penis tourniquet syndrome ]]
*[[Pennyroyal oil]]
*[[Peppermint oil ]]
*[[Petroleum distillates ]]
*[[Phenazopyridine]]
*[[Phenol ]]
*[[Phenolphthalein]]
*[[Phensuximide]]
*[[Phosphine ]]
*[[Phyllodes tumor of the prostate ]]
*[[Pierson syndrome ]]
*[[Pindone rodenticide poisoning ]]
*[[Pixantrone]]
*[[Polycystic kidney disease]]
*[[Porphyria ]]
*[[Precalicial canalicular ectasia]]
*[[Prostate cancer ]]
*[[Prostatic abscess ]]
*[[Prostatitis ]]
*[[Pyelonephritis ]]
*[[Quebec platelet disorder]]
*[[Ratak plus rodenticide poisoning]]
*[[Reflux nephropathy ]]
*[[Reiter’s syndrome ]]
*[[Renal abscess ]]
*[[Renal cancer ]]
*[[Renal colic ]]
*[[Renal failure]]
*[[Renal hypertension]]
*[[Renal mucormycosis ]]
*[[Renal nutcracker syndrome ]]
*[[Renal zygmycosis ]]
*[[Renovascular hypertension ]]
*[[Rhabdoid tumor ]]
*[[Rhabdomyolysis]]
*[[Rhubarb ]]
*[[Rifabutin]]
*[[Rifampicin]]
*[[Rodend rodenticide poisoning ]]
*[[Rue]]
*[[Salcedo syndrome ]]
*[[Sarcoma botryoides ]]
*[[Schistosomiasis ]]
*[[Senna ]]
*[[Southworth symptom complex]]
*[[Spirochetes disease ]]
*[[Stones ]]
*[[Stuart factor deficiency]]
*[[Sulphasalazine]]
*[[Talon rodenticide poisoning ]]
*[[Thalassemia ]]
*[[Thrombasthenia ]]
*[[Thrombocytopathy ]]
*[[Thrombocytopenia]]
*[[Thrombocytopenic purpura]]
*[[Torulopsis ]]
*[[Toxic epidermal necrolysis ]]
*[[Toxic mushrooms ]]
*[[Transitional cell carcinoma]]
*[[Trichosporin infection ]]
*[[Tuberculosis ]]
*[[Turpentine oil ]]
*[[Urachal cancer ]]
*[[Urachal cyst ]]
*[[Urban schosser spohn syndrome ]]
*[[Ureter cancer ]]
*[[Urethral cancer ]]
*[[Urinary disorders ]]
*[[Urinary stones ]]
*[[Urinary system cancer ]]
*[[Urinary tract infections ]]
*[[Urod-related porphyria cutanea tarda]]
*[[Vasculitis hypersensitivity ]]
*[[Vasculitis ]]
*[[Volak rodenticide poisoning ]]
*[[Volid rodenticide poisoning ]]
*[[Wegener's granulomatosis ]]
*[[Weil syndrome ]]
*[[Wilms tumor ]]
*[[Wilson's disease ]]
*[[Xanthic urolithiasis ]]
*[[Xanthine oxydase deficiency ]]
*[[Xanthinuria]]
*[[Yellow fever ]]
}}
</div>


==References==
==References==
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{{WH}}
{{WH}}
{{WS}}
{{WS}}


[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Signs and symptoms]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Urologic Surgery]]
[[Category:Urologic Surgery]]
[[Category:Gynecology]]
[[Category:Gynecology]]

Latest revision as of 21:20, 10 January 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2] Luke Rusowicz-Orazem, B.S.

Overview

Hypogonadism is commonly caused by congenital, acquired genetic and endocrinological conditions. Life threatening causes may include malignancies and must take in to consideration during patient approach.[1][2]

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. The following diseases are life threatening causes of hypogonadism:

Common Causes

Causes by Organ System

Cardiovascular Alström syndrome, Amyloidosis, Cardiofaciocutaneous syndrome, Vascular abnormalities of the cns
Chemical/Poisoning Alcohol, Alkylating agents, Cytotoxic therapeutic agents, Environmental toxins, Ethanol, Toxins
Dental Jaffe-campanacci syndrome, Lepromatous leprosy
Dermatologic No underlying causes
Drug Side Effect Antiandrogens, Ketoconazole, Marijuana use, Opioids
Ear Nose Throat No underlying causes
Endocrine Adiposogenital dystrophy, Adrenal hypoplasia, Autoimmune polyendocrine syndrome type 2, Combined pituitary hormone deficiency , Disorders of androgen synthesis, Functional gonadotropin deficiency, Glucocorticoids, Glycoprotein syndrome type 1, Gonadal dysgenesis , Growth hormone secreting pituitary adenoma, Hyperprolactinemia, Hypogonadic hypogonadism, Hypopituitarism, Hypothalamic glioma, Panhypopituitarism, Pituitary tumor, Poems syndrome, Polycystic ovarian disease, Proprotein convertase 1/3 deficiency, Pseudohypoparathyroidism type 1a, Swyer's syndrome, Testicular biosynthetic defects
Environmental No underlying causes
Gastroenterologic Hepatic cirrhosis
Genetic 17α-hydroxylase deficiency, 17β-hydroxysteroid dehydrogenase iii deficiency, 20-lyase deficiency, 48, xxxy aneuploidy, 48, xxyy aneuploidy, 4h syndrome, Acrocephalopolysyndactyly type 2, Alström syndrome, Aromatase deficiency, Autoimmune oophoritis, Bardet-biedl syndrome, Belgian type mental retardation, Blepharophimosis syndrome, Borjeson-forssman-lehmann syndrome, Boucher-neuhäuser syndrome, Cardiofaciocutaneous syndrome, Ccfdn syndrome, Charge syndrome, Congenital adrenal hypoplasia, Craniofacial anomalies, Craniopharyngioma, Cryptorchidism, Didmoad syndrome, Dystrophia myotonica type 2, Fsh receptor deficiency, Fsh beta subunit mutation (follicle stimulating hormone), Fsh receptor mutation, Galactose-1-phosphate uridyltransferase deficiency, Galactosemia, Gaucher disease, Gordon holmes syndrome, Hartsfield syndrome, Image syndrome, Isolated fsh deficiency, Isolated lh deficiency, Jaffe-campanacci syndrome, Kallmann syndrome, Klinefelter syndrome, Laurence-moon syndrome, Leptin deficiency, Lh (luteinizing hormone) beta subunit mutation, Lh receptor mutation, Lh resistance, Lipoid congenital adrenal hyperplasia, Malouf syndrome, Marinesco-sjogren-garland syndrome, Martsolf syndrome, Mobius syndrome, Mosaicism, Myotonic dystrophy, Noonan syndrome, Prader-willi syndrome, Proprotein convertase 1/3 deficiency, Resistant ovary, Rud syndrome, Sertoli-cell-only syndrome, Turner syndrome, Woodhouse-sakati syndrome, X-linked mental retardation-hypotonic facies syndrome, Xx gonadal dysgenesis
Hematologic Glycoprotein syndrome type 1, Hemochromatosis, Langerhans histiocytosis, Leukoencephalopathy , Zinc deficiency
Iatrogenic Chemotherapy, Opioids, Orchitis, Radiation therapy, Surgery
Infectious Disease Aids, Infections, Mumps
Musculoskeletal/Orthopedic No underlying causes
Neurologic Astrocytoma, Belgian type mental retardation, Craniopharyngioma, Gordon holmes syndrome, Poems syndrome, Postinfectious lesions of the central nervous system (cns), Vascular abnormalities of the cns
Nutritional/Metabolic Zinc deficiency
Obstetric/Gynecologic Exercise-induced amenorrhea, Ovarian resistance syndrome, Ovarian torsion, Polycystic ovarian disease, Premature ovarian failure, Premature menopause, Resistant ovary, Rud syndrome, Suramin, Swyer's syndrome
Oncologic Astrocytoma, Germinoma, Growth hormone secreting pituitary adenoma, Hypothalamic glioma, Langerhans histiocytosis, Optic glioma, Other germ cell tumors, Pituitary tumor
Ophthalmologic Optic glioma
Overdose/Toxicity Alcohol
Psychiatric Anorexia nervosa
Pulmonary No underlying causes
Renal/Electrolyte Chronic renal failure, Renal failure
Rheumatology/Immunology/Allergy Amyloidosis, Autoimmune damage, Autoimmunity, Chronic systemic illnesses, Lepromatous leprosy
Sexual Aids, Epididymo-orchitis, Germinoma, Orchidectomy, Suramin
Trauma Head trauma, Hepatic cirrhosis, Ovarian torsion, Testicular torsion, Trauma
Urologic Anorchia, Anorchidism, Congenital hypogonadotropic hypogonadism, Cryptorchidism, Disorders of androgen synthesis, Epididymo-orchitis, Gonadal dysgenesis , Hypogonadic hypogonadism, Orchitis, Testicular torsion, Varicocele
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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