Toxic multinodular goiter causes: Difference between revisions
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{{Toxic multinodular goiter}} | {{Toxic multinodular goiter}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{SKA}} | ||
==Overview== | ==Overview== | ||
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===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
List the causes of the disease in alphabetical order. | List the causes of the disease in alphabetical order. | ||
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* | * Genetic base substitution mutations on exon 10 of chromosome 14q31. | ||
* Cause 2 | * Cause 2 | ||
* Cause 3 | * Cause 3 | ||
Latest revision as of 23:08, 10 January 2020
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Toxic multinodular goiter Microchapters |
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Differentiating Toxic multinodular goiter from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Toxic multinodular goiter causes On the Web |
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American Roentgen Ray Society Images of Toxic multinodular goiter causes |
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Risk calculators and risk factors for Toxic multinodular goiter causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]
Overview
The progression to Toxic multinodular goiter usually involves the somatic gain-of-function mutations in the TSH receptor gene.
Causes
The causes of toxic multinodular goiter are as follows:[1][2][3][4]
Genetic Causes
- The development of multi-nodular goiter is the result of multiple genetic base substitution mutations on exon 10 of chromosome 14q31.
| Frequency of mutation | TSHr gene codon | base substitution | amino acid change |
|---|---|---|---|
| Common | 486 | ATC/ATG | Ile/Met |
| Common | 632 | ACC/ATC | Thr/Ile |
| Less common | 619 | GAT/GGT | Asp/Gly |
| Less common | 623 | GCC/GTC | Ala/Val |
| Less common | 629 | TTG/TTT | Leu/Phe |
| Less common | 630 | ATC/CTC | Ile/Leu |
| Less common | 633 | GAC/GAG | Asp/Glu |
| Less common | 639 | CCA/TCA | Pro/Ser |
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | The development of multi-nodular goiter is the result of multiple genetic base substitution mutations on exon 10 of chromosome 14q31. |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
- Genetic base substitution mutations on exon 10 of chromosome 14q31.
- Cause 2
- Cause 3
- Cause 4
- Cause 5
- Cause 6
- Cause 7
- Cause 8
- Cause 9
- Cause 10