Dressler's syndrome: Difference between revisions

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==Pathophysiology==
==Pathophysiology==


* Although the exact cause remains unknown, Dressler's syndrome is believed to result from an [[autoimmune]] [[Inflamation|inflammatory reaction]] to [[Myocardium|myocardial]] [[Antigens|neo-antigens]], as well as injury to the mesothelial pericardial cells.<ref name="pmid785768">{{cite journal| author=Engle MA, Zabriskie JB, Senterfit LB| title=Heart-reactive antibody, viral illness, and the postpericardiotomy syndrome. Correlates of a triple-blind, prospective study. | journal=Trans Am Clin Climatol Assoc | year= 1976 | volume= 87 | issue=  | pages= 147-60 | pmid=785768 | doi= | pmc=2441394 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=785768  }}</ref>
* Although the exact cause remains unknown, Dressler's syndrome is believed to result from an [[autoimmune]] [[Inflamation|inflammatory reaction]] to [[Myocardium|myocardial]] [[Antigens|neo-antigens]], as well as injury to the [[Mesothelium|mesothelial]] [[pericardial]] [[Cell (biology)|cells]].<ref name="pmid785768">{{cite journal| author=Engle MA, Zabriskie JB, Senterfit LB| title=Heart-reactive antibody, viral illness, and the postpericardiotomy syndrome. Correlates of a triple-blind, prospective study. | journal=Trans Am Clin Climatol Assoc | year= 1976 | volume= 87 | issue=  | pages= 147-60 | pmid=785768 | doi= | pmc=2441394 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=785768  }}</ref>
* It usually occurs within weeks or months of the [[infarction]] due to antimyocardial antibodies; this begins with [[myocardial injury]] that releases [[Heart|cardiac]] [[Antigen|antigens]] and stimulates [[antibody]] formation.
* It usually occurs within weeks or months of the [[infarction]] due to antimyocardial [[antibodies]]; this begins with [[myocardial injury]] that releases [[Heart|cardiac]] [[Antigen|antigens]] and stimulates [[antibody]] formation.
* The [[immune complexes]] that are generated as anti-actin and actomycin antibodies deposit onto the [[pericardium]] and causes [[inflammation]].
* The [[immune complexes]] that are generated as anti-[[actin]] and [[actomyosin]] [[antibodies]] deposit onto the [[pericardium]] and causes [[inflammation]].
* The [[Autoimmunity|autoimmune response]] and [[syndrome]] may also develop secondary to [[pulmonary embolism]].<ref name="pmid8759817">{{cite journal| author=Jerjes-Sánchez C, Ramírez-Rivera A, Ibarra-Pérez C| title=The Dressler syndrome after pulmonary embolism. | journal=Am J Cardiol | year= 1996 | volume= 78 | issue= 3 | pages= 343-5 | pmid=8759817 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8759817  }} </ref>
* The [[Autoimmunity|autoimmune response]] and [[syndrome]] may also develop [[secondary]] to [[pulmonary embolism]].<ref name="pmid8759817">{{cite journal| author=Jerjes-Sánchez C, Ramírez-Rivera A, Ibarra-Pérez C| title=The Dressler syndrome after pulmonary embolism. | journal=Am J Cardiol | year= 1996 | volume= 78 | issue= 3 | pages= 343-5 | pmid=8759817 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8759817  }} </ref>


===Gross Pathology===
===Gross Pathology===
Gross pathological examination may show the following findings <ref name="pmid26240567">{{cite journal| author=Feola A, De Stefano N, Della Pietra B| title=Pericarditis Epistenocardica or Dressler Syndrome? An Autopsy Case. | journal=Case Rep Med | year= 2015 | volume= 2015 | issue=  | pages= 215340 | pmid=26240567 | doi=10.1155/2015/215340 | pmc=4512600 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26240567  }}</ref>:
[[Gross examination|Gross]] [[pathological]] [[examination]] may show the following findings: <ref name="pmid26240567">{{cite journal| author=Feola A, De Stefano N, Della Pietra B| title=Pericarditis Epistenocardica or Dressler Syndrome? An Autopsy Case. | journal=Case Rep Med | year= 2015 | volume= 2015 | issue=  | pages= 215340 | pmid=26240567 | doi=10.1155/2015/215340 | pmc=4512600 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26240567  }}</ref>


* Fine granular layer on the epicardial surface with a “bread and butter” appearance.
* Fine granular layer on the [[epicardial]] surface with a “[[bread]] and [[butter]]” appearance.
*Because Dressler's syndrome is more common with transmural infarctions, the causing infarction is likely to be seen.
*Because Dressler's syndrome is more common with transmural [[Infarction|infarctions]], the causing [[infarction]] is likely to be seen.


[[File:CRIM2015-215340.001.jpg|center|thumb|The epicardium was characterized by a fine granular layer on its surface with a “bread and butter” appearance, particularly at the level of the atrial regions and the cardiac apex in a case of Dressler's syndrome. <ref>https://www.hindawi.com/journals/crim/2015/215340/fig1//</ref>]]
[[File:CRIM2015-215340.001.jpg|center|thumb|The epicardium was characterized by a fine granular layer on its surface with a “bread and butter” appearance, particularly at the level of the atrial regions and the cardiac apex in a case of Dressler's syndrome. <ref>https://www.hindawi.com/journals/crim/2015/215340/fig1//</ref>]]
<br />
<br />
=== Microscopic Pathology ===
=== Microscopic Pathology ===
Microscopic examination of the myocardial tissue sections may show <ref name="pmid262405672">{{cite journal| author=Feola A, De Stefano N, Della Pietra B| title=Pericarditis Epistenocardica or Dressler Syndrome? An Autopsy Case. | journal=Case Rep Med | year= 2015 | volume= 2015 | issue=  | pages= 215340 | pmid=26240567 | doi=10.1155/2015/215340 | pmc=4512600 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26240567  }}</ref>:
[[Microscopic]] [[examination]] of the [[Myocardium|myocardial]] [[Tissue (biology)|tissue]] sections may show: <ref name="pmid262405672">{{cite journal| author=Feola A, De Stefano N, Della Pietra B| title=Pericarditis Epistenocardica or Dressler Syndrome? An Autopsy Case. | journal=Case Rep Med | year= 2015 | volume= 2015 | issue=  | pages= 215340 | pmid=26240567 | doi=10.1155/2015/215340 | pmc=4512600 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26240567  }}</ref>


* Plurifocal signs of myocardial [[sclerosis]] may be detected.
* Plurifocal signs of [[Myocardium|myocardial]] [[sclerosis]] may be detected.
*Lymphocytic perimyofibrillar microinfiltrations may be seen.
*[[Lymphocytic]] perimyofibrillar microinfiltrations may be seen.
*Localized [[lipofuscin]] pigment deposits in the myocytes.
*Localized [[lipofuscin]] [[pigment]] deposits in the [[myocytes]].


==Causes==
==Causes==
The common causes of Dressler's syndrome include <ref name="pmid28723017">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume=  | issue=  | pages=  | pmid=28723017 | doi= | pmc= | url= }}</ref>:
The common causes of Dressler's syndrome include: <ref name="pmid28723017">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume=  | issue=  | pages=  | pmid=28723017 | doi= | pmc= | url= }}</ref>


*Surgeries associated with myocardial damage as
*[[Surgery|Surgeries]] associated with [[Myocardium|myocardial]] damage
**[[Coronary artery bypass grafting]] and  
**[[Coronary artery bypass grafting]] and
**Aortic valve replacement.
**Aortic valve replacement.
*[[Myocardial infarction]]
*[[Myocardial infarction]]
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==Differentiating Dressler's Syndrome from other Diseases==
==Differentiating Dressler's Syndrome from other Diseases==
Dressler's syndrome typically occurs 2 to 10 weeks after a myocardial infarction has occurred.<ref name=":0">{{cite journal | author = Krainin F, Flessas A, Spodick D | title = Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram. | journal = N Engl J Med | volume = 311 | issue = 19 | pages = 1211-4 | year = 1984 | id = PMID 6493274}}</ref><ref>{{cite journal | author = Krainin F, Flessas A, Spodick D | title = Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram. | journal = N Engl J Med | volume = 311 | issue = 19 | pages = 1211-4 | year = 1984 | id = PMID 6493274}}</ref> This differentiates Dressler's syndrome from


* [[Post myocardial infarction pericarditis]] that occurs in 17,000 to 25,000 in every 100,000 cases of [[acute myocardial infarction]] between days 2 and 4 after the [[ST elevation myocardial infarction|myocardial infarction.]]
* Dressler's syndrome typically occurs 2 to 10 weeks after a [[myocardial infarction]] has occurred.<ref name=":0">{{cite journal | author = Krainin F, Flessas A, Spodick D | title = Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram. | journal = N Engl J Med | volume = 311 | issue = 19 | pages = 1211-4 | year = 1984 | id = PMID 6493274}}</ref><ref>{{cite journal | author = Krainin F, Flessas A, Spodick D | title = Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram. | journal = N Engl J Med | volume = 311 | issue = 19 | pages = 1211-4 | year = 1984 | id = PMID 6493274}}</ref>
* This differentiates Dressler's syndrome from:


*[[Pulmonary embolism]], another identifiable cause of [[pleuritic]] (and non-pleuritic) [[chest pain]] in people who have been hospitalized and/or undergone [[Surgical procedure|surgical procedures]] within the preceding weeks.
**[[Post myocardial infarction pericarditis]] that occurs in 17,000 to 25,000 in every 100,000 cases of [[acute myocardial infarction]] between days 2 and 4 after the [[ST elevation myocardial infarction|myocardial infarction.]]


Further, Dressler's syndrome should be differentiated from:
**[[Pulmonary embolism]], another identifiable cause of [[pleuritic]] (and non-[[pleuritic]]) [[chest pain]] in people who have been [[Hospitalization|hospitalized]] and/or undergone [[Surgical procedure|surgical procedures]] within the preceding weeks.


*[[Congestive Heart Failure]]: Another complication of MI that may occur in a more acute setting.  
* Dressler's syndrome should be differentiated from:
*Acute [[anemia]] (e.g. hemorrhage): shares the same symptoms as malaise, dyspnea, and palpitations.
 
*[[Uremia]]: may lead to pericarditis that must be differentiated from Dressler's syndrome.
**[[Congestive Heart Failure]]: Another complication of MI that may occur in a more acute setting.
**Acute [[anemia]] (e.g., [[hemorrhage]]): shares the same [[Symptom|symptoms]] as [[malaise]], [[dyspnea]], and [[Palpitation|palpitations]].
**[[Uremia]]: may lead to pericarditis that must be differentiated from Dressler's syndrome.


==Epidemiology and Demographics==
==Epidemiology and Demographics==


* Incidence: In the setting of [[ST elevation myocardial infarction|myocardial infarction]], Dressler's syndrome was classically reported to occur in about 3 to 4% of MI cases.<ref>{{cite journal | author = Krainin F, Flessas A, Spodick D | title = Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram. | journal = N Engl J Med | volume = 311 | issue = 19 | pages = 1211-4 | year = 1984 | id = PMID 6493274}}</ref>
*[[Incidence]]: In the setting of [[ST elevation myocardial infarction|myocardial infarction]], Dressler's syndrome was classically reported to occur in about 3 to 4% of [[MI]] cases.<ref>{{cite journal | author = Krainin F, Flessas A, Spodick D | title = Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram. | journal = N Engl J Med | volume = 311 | issue = 19 | pages = 1211-4 | year = 1984 | id = PMID 6493274}}</ref>
*However, the incidence has markedly decreased in the [[reperfusion]] era (between 0.5 to 2%), presumably because of smaller infarct sizes.<ref name="pmid2643287">{{cite journal| author=Tofler GH, Muller JE, Stone PH, Willich SN, Davis VG, Poole WK et al.| title=Pericarditis in acute myocardial infarction: characterization and clinical significance. | journal=Am Heart J | year= 1989 | volume= 117 | issue= 1 | pages= 86-92 | pmid=2643287 | doi= | pmc= | url= }} </ref>
*However, the [[incidence]] has markedly decreased in the [[reperfusion]] era (between 0.5 to 2%), presumably because of smaller [[Infarction|infarct]] sizes.<ref name="pmid2643287">{{cite journal| author=Tofler GH, Muller JE, Stone PH, Willich SN, Davis VG, Poole WK et al.| title=Pericarditis in acute myocardial infarction: characterization and clinical significance. | journal=Am Heart J | year= 1989 | volume= 117 | issue= 1 | pages= 86-92 | pmid=2643287 | doi= | pmc= | url= }} </ref>
*Age: Dressler's syndrome occurs more often in younger age groups.
*Age: Dressler's syndrome occurs more often in younger age groups.
*Gender: There is no gender predilection for Dressler's syndrome.
*Gender: There is no gender predilection for Dressler's syndrome.
*Race: There is no racial predilection for Dressler's syndrome.
*Race: There is no racial predilection for Dressler's syndrome.
*Mortality rate: The prognosis is usually favorable with early treatment with a low mortality rate.
*[[Mortality rate]]: The [[prognosis]] is usually favorable with early treatment with a low [[mortality rate]].


==Risk Factors==
==Risk Factors==


* The risk of Dressler's syndrome increases with the size of the [[infarction]].  
* The risk of Dressler's syndrome increases with the size of the [[infarction]].  
* Further, a former episode of [[Dressler's syndrome]] increases the risk of [[relapse]] upon recurrent [[ST elevation myocardial infarction|MI]] (most important risk factor).
* Further, a former episode of Dressler's syndrome increases the risk of [[relapse]] upon recurrent [[ST elevation myocardial infarction|MI]] (the most important [[risk factor]]).
* Epidemiological studies showed a higher risk ratio of [[Dressler's syndrome]] with <ref name="pmid287230172">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume=  | issue=  | pages=  | pmid=28723017 | doi= | pmc= | url= }}</ref>:
*[[Epidemiology|Epidemiological]] studies showed a higher risk ratio of Dressler's syndrome with: <ref name="pmid287230172">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume=  | issue=  | pages=  | pmid=28723017 | doi= | pmc= | url= }}</ref>


** Cardiac surgeries associated with greater myocardial damage as [[aortic valve replacement]].
**[[Cardiac surgery|Cardiac surgeries]] associated with greater [[Myocardium|myocardial]] damage as [[aortic valve replacement]]
** Younger age
** Younger age
** Prior treatment with [[prednisone]]
** Prior treatment with [[prednisone]]
** B -ve [[blood type]]
** B-negative [[blood type]]
**[[Halothane]] anesthesia
**[[Halothane]] [[anesthesia]]
**[[Virus|Viral infections]] that have been associated with [[Dressler's syndrome]] (based on the seasonal variations in [[incidence]] and elevated blood levels of viral components in [[Dressler's syndrome (patient information)|Dressler's Syndrome]] patients) include<ref name="pmid7857682">{{cite journal| author=Engle MA, Zabriskie JB, Senterfit LB| title=Heart-reactive antibody, viral illness, and the postpericardiotomy syndrome. Correlates of a triple-blind, prospective study. | journal=Trans Am Clin Climatol Assoc | year= 1976 | volume= 87 | issue=  | pages= 147-60 | pmid=785768 | doi= | pmc=2441394 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=785768  }}</ref>:
**[[Virus|Viral infections]] that have been associated with Dressler's syndrome (based on the seasonal variations in [[incidence]] and elevated [[blood]] levels of [[Virus|viral]] components in [[Dressler's syndrome (patient information)|Dressler's Syndrome]] [[Patient|patients]]), including: <ref name="pmid7857682">{{cite journal| author=Engle MA, Zabriskie JB, Senterfit LB| title=Heart-reactive antibody, viral illness, and the postpericardiotomy syndrome. Correlates of a triple-blind, prospective study. | journal=Trans Am Clin Climatol Assoc | year= 1976 | volume= 87 | issue=  | pages= 147-60 | pmid=785768 | doi= | pmc=2441394 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=785768  }}</ref>
***[[Coxsackie B virus]]
***[[Coxsackie B virus]]
***[[Adenovirus]]
***[[Adenovirus]]
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=== Natural History ===
=== Natural History ===


* Dressler's syndrome typically occurs 2 to 10 weeks after a myocardial infarction has occurred.<ref name=":0" />
* Dressler's syndrome typically occurs 2 to 10 weeks after a [[myocardial infarction]] has occurred.<ref name=":0" />
* The symptoms for Dressler's syndrome starts mild and then progress to reach the full clinical profile.  
* The [[Symptom|symptoms]] for Dressler's syndrome starts mild and then progress to reach the full clinical profile.
* The condition is usually acute; however, some patients may develop chronic pericardial inflammation.
* The condition is usually [[Acute (medicine)|acute]]; however, some [[Patient|patients]] may develop [[Chronic (medical)|chronic]] [[pericardial]] [[inflammation]].
* The prognosis is usually favorable with early treatment.
* The [[prognosis]] is usually favorable with early treatment.
* Untreated or poorly treated patients may develop cardiac tamponade (acute) or constrictive pericarditis (chronic).
* Untreated or poorly treated [[Patient|patients]] may develop [[cardiac tamponade]] ([[Acute (medicine)|acute]]) or [[constrictive pericarditis]] ([[Chronic (medical)|chronic]]).


=== Complications ===
=== Complications ===
The complications of Dressler's syndrome may include <ref name="pmid287230173">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume=  | issue=  | pages=  | pmid=28723017 | doi= | pmc= | url= }}</ref>:
The [[Complication (medicine)|complications]] of Dressler's syndrome may include: <ref name="pmid287230173">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume=  | issue=  | pages=  | pmid=28723017 | doi= | pmc= | url= }}</ref>


*[[Pericardial effusion]] may result from the accumulation of fluids as a result of inflammation in the pericardial sac.
*[[Pericardial effusion]] may result from the accumulation of [[fluids]] as a result of [[inflammation]] in the [[pericardial sac]].
*[[Cardiac tamponade]] can occur if the accumulation of fluids in the pericardium is large enough and rapid enough.
*[[Cardiac tamponade]] can occur if the accumulation of [[Fluid|fluids]] in the [[pericardium]] is large enough and rapid enough.
*[[Constrictive pericarditis]] can occur if there is a chronic inflammatory response
*[[Constrictive pericarditis]] can occur if there is a [[Chronic inflammation|chronic inflammatory]] response.


=== Prognosis ===
=== Prognosis ===


* The prognosis for patients with DS is usually favorable, even those requiring [[Pericardiocentesis|pericardial drainage]].  
* The [[prognosis]] for patients with Dressler's syndrome is usually favorable, even those requiring [[Pericardiocentesis|pericardial drainage]].
* However, the latter patients have a higher risk for fluid reaccumulation and repeat [[pericardiocentesis]].  
* However, the latter [[Patient|patients]] have a higher risk for [[fluid]] reaccumulation and repeat [[pericardiocentesis]].  
* Otherwise, [[constrictive pericarditis]] would occur leading to the need for [[pericardial stripping]].
* Otherwise, [[constrictive pericarditis]] would occur leading to the need for [[pericardial stripping]].


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===History and Symptoms===
===History and Symptoms===
The syndrome consists of a persistent low-grade [[fever]], and [[chest pain]] which is usually [[pleuritic]] in nature.The symptoms tend to occur after a few weeks or even months after [[myocardial infarction]] and tend to subside in a few days<ref name="pmid165531112">{{cite journal| author=Wessman DE, Stafford CM| title=The postcardiac injury syndrome: case report and review of the literature. | journal=South Med J | year= 2006 | volume= 99 | issue= 3 | pages= 309-14 | pmid=16553111 | doi=10.1097/01.smj.0000203330.15503.0b | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16553111  }}</ref>.
The syndrome consists of a persistent low-grade [[fever]] and [[chest pain]] which is usually [[pleuritic]] in nature.The symptoms enlisted below tend to occur after a few weeks or even months after [[myocardial infarction]] and tend to subside in a few days: <ref name="pmid165531112">{{cite journal| author=Wessman DE, Stafford CM| title=The postcardiac injury syndrome: case report and review of the literature. | journal=South Med J | year= 2006 | volume= 99 | issue= 3 | pages= 309-14 | pmid=16553111 | doi=10.1097/01.smj.0000203330.15503.0b | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16553111  }}</ref>


*[[Malaise]]
*[[Malaise]]
*[[Irritability]]
*[[Irritability]]
*[[Anorexia]]
*[[Anorexia|Lack of appetite]]
*[[Dyspnea]] (with or without [[hypoxia]])
*[[Dyspnea|Difficulty breathing]] (with or without [[hypoxia]])
*[[Palpitations]]
*[[Palpitations]]
*[[Arthralgias]]
*[[Arthralgias|Pain in the joints]]
*
*


===Physical Examination===
===Physical Examination===
Physical examination of patients with Dressler's syndrome may show<ref name="pmid287230173" />:
[[Physical examination]] of patients with Dressler's syndrome may show<ref name="pmid287230173" />:


*[[Pericardial friction rub]]: This characteristic sign may disappear secondary to either improvement in or worsening of accumulation of pericardial fluid
*[[Pericardial friction rub]]: This characteristic sign may disappear secondary to either improvement in or worsening of accumulation of pericardial fluid
*[[Tachycardia]]
*[[Tachycardia]]
*[[Pulsus paradoxus]] (>10 mmHg decrease in blood pressure with inspiration and decreased pulse amplitude on the [[radial artery]]).
*[[Pulsus paradoxus]] (>10 mmHg decrease in blood pressure with inspiration and decreased pulse amplitude on the [[radial artery]]).
*Signs of [[pneumonitis]] (e.g., a cough, decreased oxygen saturation, fever).
*Signs of [[pneumonitis]] (e.g., a cough, decreased oxygen saturation, and fever).
*Minimal respiratory symptoms to significant [[respiratory distress]] with large [[Pleural effusion|pleural effusions]].
*Minimal respiratory symptoms to significant [[respiratory distress]] with large [[Pleural effusion|pleural effusions]].


===Laboratory Findings===
===Laboratory Findings===
The laboratory work-up of patients with Dressler's syndrome may include<ref name="pmid287230173" />:
The laboratory work-up of patients with Dressler's syndrome may include: <ref name="pmid287230173" />


* [[Blood culture]]: can differentiate between [[Inflammation|inflammatory]] and infectious [[pericarditis]] (should be negative in Dressler's syndrome).
* [[Blood culture]]: can differentiate between [[Inflammation|inflammatory]] and [[Infection|infectious]] [[pericarditis]] (should be negative in Dressler's syndrome)


* [[Leukocytosis|Leucocytosis]] (with a leftward shift)
* [[Leukocytosis|Leucocytosis]] (with a leftward shift)
* Elevated [[acute phase reactant]]<nowiki/>s (e.g. [[Erythrocyte sedimentation rate|ESR]] and [[C-reactive protein|CRP]]).
* Elevated [[acute phase reactant]]<nowiki/>[[acute phase reactant|s]] (e.g., [[Erythrocyte sedimentation rate|ESR]] and [[C-reactive protein|CRP]])
* High serum titers of anti-cardiac antibodies.
* High serum titers of anti-cardiac antibodies
* The [[pericardial fluid]] may be examined for cell count, culture, [[Serum total protein|total protein]]<nowiki/>s, and [[triglyceride]] levels
* The [[pericardial fluid]] may be examined for cell count, culture, [[Serum total protein|total protein]]<nowiki/>s, and [[triglyceride]] levels


=== Electrocardiogram ===
=== Electrocardiogram ===
An electrocardiograph (ECG) may demonstrate<ref name="pmid24062911">{{cite journal| author=Hendry C, Liew CK, Chauhan A, Zacharias J| title=A life-saving case of Dressler's syndrome. | journal=Eur Heart J Acute Cardiovasc Care | year= 2012 | volume= 1 | issue= 3 | pages= 232-5 | pmid=24062911 | doi=10.1177/2048872612452319 | pmc=3760538 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24062911  }}</ref>:
An ECG may demonstrate: <ref name="pmid24062911">{{cite journal| author=Hendry C, Liew CK, Chauhan A, Zacharias J| title=A life-saving case of Dressler's syndrome. | journal=Eur Heart J Acute Cardiovasc Care | year= 2012 | volume= 1 | issue= 3 | pages= 232-5 | pmid=24062911 | doi=10.1177/2048872612452319 | pmc=3760538 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24062911  }}</ref>  


*[[ST segment elevation]]
*[[ST segment elevation]]
*[[T wave inversion|T-wave inversion]] (as with [[pericarditis]]).
*[[T wave inversion|T-wave inversion]] (as with [[pericarditis]]).
*[[Depressed PR segment|PR depression]]
*[[Depressed PR segment|PR depression]]
* Variations in the amplitude or directionality of [[QRS complex|QRS]] from beat to beat and/or a low voltage QRS.
* Variations in the [[amplitude]] or directionality of [[QRS complex|QRS]] from beat to beat and/or a low voltage [[QRS complex|QRS]]


[[File:ECG-Pericarditis.jpg|center|thumb|Widespread concave ST elevation and PR depression is present throughout the precordial (V2-6) and limb leads (I, II, aVL, aVF). Case Courtesy of Ed Burns <ref>https://litfl.com/wp-content/uploads/2018/08/ECG-Pericarditis.jpg</ref>]]
[[File:ECG-Pericarditis.jpg|center|thumb|Widespread concave ST elevation and PR depression is present throughout the precordial (V2-6) and limb leads (I, II, aVL, aVF). Case Courtesy of Ed Burns <ref>https://litfl.com/wp-content/uploads/2018/08/ECG-Pericarditis.jpg</ref>]]
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=== X-ray ===
=== X-ray ===
The findings of [[Chest X-ray|chest x-ray]] in Dressler's syndrome may include<ref name="pmid20511488">{{cite journal |vauthors=Khandaker MH, Espinosa RE, Nishimura RA, Sinak LJ, Hayes SN, Melduni RM, Oh JK |title=Pericardial disease: diagnosis and management |journal=Mayo Clin. Proc. |volume=85 |issue=6 |pages=572–93 |date=June 2010 |pmid=20511488 |pmc=2878263 |doi=10.4065/mcp.2010.0046 |url=}}</ref>:
The findings of [[Chest X-ray|chest x-ray]] in Dressler's syndrome may include: <ref name="pmid20511488">{{cite journal |vauthors=Khandaker MH, Espinosa RE, Nishimura RA, Sinak LJ, Hayes SN, Melduni RM, Oh JK |title=Pericardial disease: diagnosis and management |journal=Mayo Clin. Proc. |volume=85 |issue=6 |pages=572–93 |date=June 2010 |pmid=20511488 |pmc=2878263 |doi=10.4065/mcp.2010.0046 |url=}}</ref>


* Flattening of the [[costophrenic angle]]<nowiki/>s
* Flattening of the [[costophrenic angle]]<nowiki/>s
Line 173: Line 175:
=== Echocardiography or Ultrasound ===
=== Echocardiography or Ultrasound ===


*Confirm the presence of [[pericardial fluid]] and evaluate the potential risk of [[cardiac tamponade]].
*Echocardiography is used to:
*Evaluation of ventricular contractility and the potential risk of [[congestive heart failure]].<ref name="pmid16553111">{{cite journal |vauthors=Wessman DE, Stafford CM |title=The postcardiac injury syndrome: case report and review of the literature |journal=South. Med. J. |volume=99 |issue=3 |pages=309–14 |date=March 2006 |pmid=16553111 |doi=10.1097/01.smj.0000203330.15503.0b |url=}}</ref>
**Confirm the presence of [[pericardial fluid]] and evaluate the potential risk of [[cardiac tamponade]].
**Evaluate ventricular contractility and the potential risk of [[congestive heart failure]].<ref name="pmid16553111">{{cite journal |vauthors=Wessman DE, Stafford CM |title=The postcardiac injury syndrome: case report and review of the literature |journal=South. Med. J. |volume=99 |issue=3 |pages=309–14 |date=March 2006 |pmid=16553111 |doi=10.1097/01.smj.0000203330.15503.0b |url=}}</ref>
*
*


=== CT Scan ===
=== CT scan ===
The findings of CT scan in Dressler's syndrome may include <ref name="pmid5923769">{{cite journal| author=Levin EJ, Bryk D| title=Dressler syndrome (postmyocardial infarction syndrome). | journal=Radiology | year= 1966 | volume= 87 | issue= 4 | pages= 731-6 | pmid=5923769 | doi=10.1148/87.4.731 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5923769  }}</ref>:
The findings of CT scan in Dressler's syndrome may include: <ref name="pmid5923769">{{cite journal| author=Levin EJ, Bryk D| title=Dressler syndrome (postmyocardial infarction syndrome). | journal=Radiology | year= 1966 | volume= 87 | issue= 4 | pages= 731-6 | pmid=5923769 | doi=10.1148/87.4.731 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5923769  }}</ref>


*[[Pericardial effusion]] of varying size, may be simple (serous) or more often complex, e.g. [[hemopericardium]]
*[[Pericardial effusion]] of varying size, which may be simple (serous) or more often complex ([[hemopericardium]])
* Myocardial thinning of the infarcted region
* Myocardial thinning of the infarcted region
*[[Stent|Stents]] in the [[coronary arteries]] (e.g. post [[Percutaneous coronary intervention|PCI]]) may be present
*[[Stent|Stents]] in the [[coronary arteries]] (e.g., post [[Percutaneous coronary intervention|PCI]]) may be present


=== MRI ===
=== MRI ===
Line 190: Line 193:


* Intense late post-[[gadolinium]] enhancement of entire [[Pericardium|pericardium.]]<ref name="pmid19627595">{{cite journal| author=Steadman CD, Khoo J, Kovac J, McCann GP| title=Dressler's syndrome demonstrated by late gadolinium enhancement cardiovascular magnetic resonance. | journal=J Cardiovasc Magn Reson | year= 2009 | volume= 11 | issue=  | pages= 23 | pmid=19627595 | doi=10.1186/1532-429X-11-23 | pmc=2723097 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19627595  }}</ref>
* Intense late post-[[gadolinium]] enhancement of entire [[Pericardium|pericardium.]]<ref name="pmid19627595">{{cite journal| author=Steadman CD, Khoo J, Kovac J, McCann GP| title=Dressler's syndrome demonstrated by late gadolinium enhancement cardiovascular magnetic resonance. | journal=J Cardiovasc Magn Reson | year= 2009 | volume= 11 | issue=  | pages= 23 | pmid=19627595 | doi=10.1186/1532-429X-11-23 | pmc=2723097 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19627595  }}</ref>
* Regional thinning and akinesis of the infarcted myocardium
* Regional thinning and akinesis of the infarcted myocardium.


=== Other Imaging Findings ===
=== Other Imaging Findings ===
Line 201: Line 204:


===Medical Therapy===
===Medical Therapy===
Dressler's syndrome is typically treated with high dose (up to 650 mg PO q 4 to 6 hours) enteric-coated [[aspirin]]. [[Acetaminophen]] can be added for pain management as this does not affect the coagulation system. [[Anticoagulant|Anticoagulants]] should be discontinued if the patient develops a [[pericardial effusion]].<ref name="pmid220377383">{{cite journal |vauthors=Jaworska-Wilczynska M, Abramczuk E, Hryniewiecki T |title=Postcardiac injury syndrome |journal=Med. Sci. Monit. |volume=17 |issue=11 |pages=CQ13–14 |date=November 2011 |pmid=22037738 |doi=10.12659/msm.882029 |url=}}</ref>
Dressler's syndrome is typically treated with high dose (up to 650 mg PO q 4 to 6 hours) enteric-coated [[aspirin]]. [[Acetaminophen]] can be added for pain management as this does not affect the coagulation system. [[Anticoagulant|Anticoagulants]] should be discontinued if the patient develops a [[pericardial effusion]].<ref name="pmid220377383">{{cite journal |vauthors=Jaworska-Wilczynska M, Abramczuk E, Hryniewiecki T |title=Postcardiac injury syndrome |journal=Med. Sci. Monit. |volume=17 |issue=11 |pages=CQ13–14 |date=November 2011 |pmid=22037738 |doi=10.12659/msm.882029 |url=}}</ref>


'''"2017 Revised ESC Guidelines for the Management of ST-Elevation Myocardial Infarction (DO NOT EDIT)'''  
'''"2017 Revised ESC Guidelines for the Management of ST-Elevation Myocardial Infarction (DO NOT EDIT)'''  
Line 238: Line 241:
=== Surgery ===
=== Surgery ===


* No surgical intervention is recommended in the management of [[Dressler's syndrome]].
* No surgical intervention is recommended in the management of Dressler's syndrome.
*[[Pericardiocentesis]] is rarely required, except for cases of haemodynamic compromise with signs of [[Cardiac tamponade|tamponade]]<ref name="pmid287230173" />.
*[[Pericardiocentesis]] is rarely required, except for cases of hemodynamic compromise with signs of [[Cardiac tamponade|tamponade]]<ref name="pmid287230173" />.


=== Primary Prevention ===
=== Primary Prevention ===
Line 249: Line 252:


* Recurrence of Dressler's syndrome is common and [[relapse]]<nowiki/>s were reported up to 1 year following the event.  
* Recurrence of Dressler's syndrome is common and [[relapse]]<nowiki/>s were reported up to 1 year following the event.  
* Some researchers suggested that [[intravenous immunoglobulin]] therapy has some benefit in resistant cases.<ref name="pmid25287461">{{cite journal| author=del Fresno MR, Peralta JE, Granados MÁ, Enríquez E, Domínguez-Pinilla N, de Inocencio J| title=Intravenous immunoglobulin therapy for refractory recurrent pericarditis. | journal=Pediatrics | year= 2014 | volume= 134 | issue= 5 | pages= e1441-6 | pmid=25287461 | doi=10.1542/peds.2013-3900 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25287461  }}</ref><br />
* Some researchers suggest that [[intravenous immunoglobulin]] therapy has some benefit in resistant cases.<ref name="pmid25287461">{{cite journal| author=del Fresno MR, Peralta JE, Granados MÁ, Enríquez E, Domínguez-Pinilla N, de Inocencio J| title=Intravenous immunoglobulin therapy for refractory recurrent pericarditis. | journal=Pediatrics | year= 2014 | volume= 134 | issue= 5 | pages= e1441-6 | pmid=25287461 | doi=10.1542/peds.2013-3900 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25287461  }}</ref><br />





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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]; Mohammed A. Sbeih, M.D.[3]; Cafer Zorkun, M.D., Ph.D. [4]; Nabeel Ahmed, M.B.B.S

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Synonyms and keywords: Postmyocardial infarction syndrome; PMIS; Post-cardiac injury syndrome

Overview

Dressler's syndrome or post-myocardial infarction syndrome is a form of pericarditis that occurs in the setting of myocardial infarction. It typically occurs 2 to 10 weeks after myocardial infarction. Dressler's syndrome results from an autoimmune inflammatory reaction to myocardial neo-antigens. Possible complications include pericardial effusion, cardiac tamponade, and constrictive pericarditis; however, the prognosis is usually favorable with early treatment. The diagnostic criteria of Dressler's syndrome depend on pleuritic chest pain, pericardial friction rub, ECG changes, and echocardiography-detected pericardial effusion. The recommended medical treatments include aspirin and colchicine.

Historical Perspective

  • Dressler's syndrome was first characterized by William Dressler in 1956.
  • It should not be confused with the Dressler's syndrome of hemoglobinuria, named after Lucas Dressler who characterized it in 1854.[1][2][3]

Classification

  • There is no established system for the classification of Dressler's syndrome.

Pathophysiology

Gross Pathology

Gross pathological examination may show the following findings: [6]

The epicardium was characterized by a fine granular layer on its surface with a “bread and butter” appearance, particularly at the level of the atrial regions and the cardiac apex in a case of Dressler's syndrome. [7]


Microscopic Pathology

Microscopic examination of the myocardial tissue sections may show: [8]

Causes

The common causes of Dressler's syndrome include: [9]

Differentiating Dressler's Syndrome from other Diseases

  • Dressler's syndrome typically occurs 2 to 10 weeks after a myocardial infarction has occurred.[10][11]
  • This differentiates Dressler's syndrome from:
  • Dressler's syndrome should be differentiated from:

Epidemiology and Demographics

  • Incidence: In the setting of myocardial infarction, Dressler's syndrome was classically reported to occur in about 3 to 4% of MI cases.[12]
  • However, the incidence has markedly decreased in the reperfusion era (between 0.5 to 2%), presumably because of smaller infarct sizes.[13]
  • Age: Dressler's syndrome occurs more often in younger age groups.
  • Gender: There is no gender predilection for Dressler's syndrome.
  • Race: There is no racial predilection for Dressler's syndrome.
  • Mortality rate: The prognosis is usually favorable with early treatment with a low mortality rate.

Risk Factors

  • The risk of Dressler's syndrome increases with the size of the infarction.
  • Further, a former episode of Dressler's syndrome increases the risk of relapse upon recurrent MI (the most important risk factor).
  • Epidemiological studies showed a higher risk ratio of Dressler's syndrome with: [14]

Screening

  • There is insufficient evidence to recommend routine screening for Dressler's syndrome.

Natural History, Complications, and Prognosis

Natural History

Complications

The complications of Dressler's syndrome may include: [16]

Prognosis

Diagnosis

Diagnostic Study of Choice

"2017 Revised ESC Guidelines for the Management of ST-Elevation Myocardial Infarction (DO NOT EDIT)

Diagnostic criteria do not differ from those for acute pericarditis including two of the following criteria: (i) pleuritic chest pain (85–90% of cases); (ii) pericardial friction rub (≤ 33% of cases); (iii) ECG changes (≤ 60% of cases), with new widespread ST-segment elevation, usually mild and progressive, or PR depression in the acute phase; and (iv) pericardial effusion (≤ 60% of cases and generally mild)".[17]

History and Symptoms

The syndrome consists of a persistent low-grade fever and chest pain which is usually pleuritic in nature.The symptoms enlisted below tend to occur after a few weeks or even months after myocardial infarction and tend to subside in a few days: [18]

Physical Examination

Physical examination of patients with Dressler's syndrome may show[16]:

Laboratory Findings

The laboratory work-up of patients with Dressler's syndrome may include: [16]

Electrocardiogram

An ECG may demonstrate: [19]

Widespread concave ST elevation and PR depression is present throughout the precordial (V2-6) and limb leads (I, II, aVL, aVF). Case Courtesy of Ed Burns [20]


X-ray

The findings of chest x-ray in Dressler's syndrome may include: [21]

  • Enlargement of the cardiac silhouette (non-specific chamber enlargement).

Echocardiography or Ultrasound

CT scan

The findings of CT scan in Dressler's syndrome may include: [23]

MRI

The findings of MRI in Dressler's syndrome may include:

Other Imaging Findings

There are no other imaging findings associated with Dressler's syndrome.

Other Diagnostic Studies

There are no other diagnostic studies associated with Dressler's syndrome.

Treatment

Medical Therapy

Dressler's syndrome is typically treated with high dose (up to 650 mg PO q 4 to 6 hours) enteric-coated aspirin. Acetaminophen can be added for pain management as this does not affect the coagulation system. Anticoagulants should be discontinued if the patient develops a pericardial effusion.[26]

"2017 Revised ESC Guidelines for the Management of ST-Elevation Myocardial Infarction (DO NOT EDIT)

  • Anti-inflammatory therapy is recommended in post-STEMI pericarditis as in post-cardiac injury pericardial syndromes for symptom relief and reduction of recurrences.
  • Aspirin is recommended as first choice of anti-inflammatory therapy post-STEMI at a dose of 500–1000 mg every 6–8 h for 1–2 weeks, decreasing the total daily dose by 250–500 mg every 1–2 weeks in keeping with 2015 ESC Guidelines for the diagnosis and management of pericardial diseases.
  • Colchicine is recommended as first-line therapy as an adjunct to aspirin/non-steroidal anti-inflammatory drug therapy (3 months) and is also recommended for the recurrent forms (6 months).
  • Corticosteroids are not recommended due to the risk of scar thinning with aneurysm development or rupture.
  • Pericardiocentesis is rarely required, except for cases of haemodynamic compromise with signs of tamponade".[27]

2013 Revised ACCF/AHA Guidelines for the Management of ST-Elevation Myocardial Infarction

Management of Pericarditis After STEMI

Class I
"1. Aspirin is recommended for treatment of pericarditis after STEMI.(Level of Evidence: B)"
Class III (Harm)
"1. Glucocorticoids and nonsteroidal antiinflammatory drugs are potentially harmful for treatment of pericarditis after STEMI. (Level of Evidence: B)"
Class IIb
"1. Administration of acetaminophen, colchicine, or narcotic analgesics may be reasonable if aspirin, even in higher doses, is not effective. (Level of Evidence: B)"

Surgery

  • No surgical intervention is recommended in the management of Dressler's syndrome.
  • Pericardiocentesis is rarely required, except for cases of hemodynamic compromise with signs of tamponade[16].

Primary Prevention

Despite the lack of guidelines on the prevention of Dressler's syndrome, MI patients with the aforementioned risk factors should be followed closely in the few weeks after the ischemic event for the early detection of signs of pericarditis.

Secondary Prevention

  • Recurrence of Dressler's syndrome is common and relapses were reported up to 1 year following the event.
  • Some researchers suggest that intravenous immunoglobulin therapy has some benefit in resistant cases.[28]


References

  1. Template:WhoNamedIt
  2. L. A. Dressler. Ein Fall von intermittirender Albuminurie und Chromaturie. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin, 1854, 6: 264-266.
  3. DRESSLER W (1956). "A post-myocardial infarction syndrome; preliminary report of a complication resembling idiopathic, recurrent, benign pericarditis". J Am Med Assoc. 160 (16): 1379–83. PMID 13306560.
  4. Engle MA, Zabriskie JB, Senterfit LB (1976). "Heart-reactive antibody, viral illness, and the postpericardiotomy syndrome. Correlates of a triple-blind, prospective study". Trans Am Clin Climatol Assoc. 87: 147–60. PMC 2441394. PMID 785768.
  5. Jerjes-Sánchez C, Ramírez-Rivera A, Ibarra-Pérez C (1996). "The Dressler syndrome after pulmonary embolism". Am J Cardiol. 78 (3): 343–5. PMID 8759817.
  6. Feola A, De Stefano N, Della Pietra B (2015). "Pericarditis Epistenocardica or Dressler Syndrome? An Autopsy Case". Case Rep Med. 2015: 215340. doi:10.1155/2015/215340. PMC 4512600. PMID 26240567.
  7. https://www.hindawi.com/journals/crim/2015/215340/fig1//
  8. Feola A, De Stefano N, Della Pietra B (2015). "Pericarditis Epistenocardica or Dressler Syndrome? An Autopsy Case". Case Rep Med. 2015: 215340. doi:10.1155/2015/215340. PMC 4512600. PMID 26240567.
  9. "StatPearls". 2019. PMID 28723017.
  10. 10.0 10.1 Krainin F, Flessas A, Spodick D (1984). "Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram". N Engl J Med. 311 (19): 1211–4. PMID 6493274.
  11. Krainin F, Flessas A, Spodick D (1984). "Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram". N Engl J Med. 311 (19): 1211–4. PMID 6493274.
  12. Krainin F, Flessas A, Spodick D (1984). "Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram". N Engl J Med. 311 (19): 1211–4. PMID 6493274.
  13. Tofler GH, Muller JE, Stone PH, Willich SN, Davis VG, Poole WK; et al. (1989). "Pericarditis in acute myocardial infarction: characterization and clinical significance". Am Heart J. 117 (1): 86–92. PMID 2643287.
  14. "StatPearls". 2019. PMID 28723017.
  15. Engle MA, Zabriskie JB, Senterfit LB (1976). "Heart-reactive antibody, viral illness, and the postpericardiotomy syndrome. Correlates of a triple-blind, prospective study". Trans Am Clin Climatol Assoc. 87: 147–60. PMC 2441394. PMID 785768.
  16. 16.0 16.1 16.2 16.3 "StatPearls". 2019. PMID 28723017.
  17. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H; et al. (2018). "2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)". Eur Heart J. 39 (2): 119–177. doi:10.1093/eurheartj/ehx393. PMID 28886621.
  18. Wessman DE, Stafford CM (2006). "The postcardiac injury syndrome: case report and review of the literature". South Med J. 99 (3): 309–14. doi:10.1097/01.smj.0000203330.15503.0b. PMID 16553111.
  19. Hendry C, Liew CK, Chauhan A, Zacharias J (2012). "A life-saving case of Dressler's syndrome". Eur Heart J Acute Cardiovasc Care. 1 (3): 232–5. doi:10.1177/2048872612452319. PMC 3760538. PMID 24062911.
  20. https://litfl.com/wp-content/uploads/2018/08/ECG-Pericarditis.jpg
  21. Khandaker MH, Espinosa RE, Nishimura RA, Sinak LJ, Hayes SN, Melduni RM, Oh JK (June 2010). "Pericardial disease: diagnosis and management". Mayo Clin. Proc. 85 (6): 572–93. doi:10.4065/mcp.2010.0046. PMC 2878263. PMID 20511488.
  22. Wessman DE, Stafford CM (March 2006). "The postcardiac injury syndrome: case report and review of the literature". South. Med. J. 99 (3): 309–14. doi:10.1097/01.smj.0000203330.15503.0b. PMID 16553111.
  23. Levin EJ, Bryk D (1966). "Dressler syndrome (postmyocardial infarction syndrome)". Radiology. 87 (4): 731–6. doi:10.1148/87.4.731. PMID 5923769.
  24. Scarfone RJ, Donoghue AJ, Alessandrini EA (August 2003). "Cardiac tamponade complicating postpericardiotomy syndrome". Pediatr Emerg Care. 19 (4): 268–71. doi:10.1097/01.pec.0000092573.40174.74. PMID 12972828.
  25. Steadman CD, Khoo J, Kovac J, McCann GP (2009). "Dressler's syndrome demonstrated by late gadolinium enhancement cardiovascular magnetic resonance". J Cardiovasc Magn Reson. 11: 23. doi:10.1186/1532-429X-11-23. PMC 2723097. PMID 19627595.
  26. Jaworska-Wilczynska M, Abramczuk E, Hryniewiecki T (November 2011). "Postcardiac injury syndrome". Med. Sci. Monit. 17 (11): CQ13–14. doi:10.12659/msm.882029. PMID 22037738.
  27. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H; et al. (2018). "2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)". Eur Heart J. 39 (2): 119–177. doi:10.1093/eurheartj/ehx393. PMID 28886621.
  28. del Fresno MR, Peralta JE, Granados MÁ, Enríquez E, Domínguez-Pinilla N, de Inocencio J (2014). "Intravenous immunoglobulin therapy for refractory recurrent pericarditis". Pediatrics. 134 (5): e1441–6. doi:10.1542/peds.2013-3900. PMID 25287461.

See also


de:Dressler-Syndrom


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