Tuberous sclerosis surgery: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Tuberous sclerosis}} | {{Tuberous sclerosis}} | ||
{{CMG}} | {{CMG}} {{AE}} {{Jose}} | ||
==Overview== | |||
Surgical options have been historically the only way to treat the TSC-associated complications, but with the introduction of the [[mTOR]] inhibitors they have been left for more severe or refractory complications. | |||
== Surgical Treatment == | |||
=== Epilepsy === | |||
* [[Vagal nerve stimulation]] or surgical resection of CNS lesion responsible for the [[epilepsy]] may be used.<ref name=":0">Henske, Elizabeth P., et al. "Tuberous sclerosis complex." ''Nature reviews Disease primers'' 2.1 (2016): 1-18.</ref> | |||
=== Angiomyolipoma === | |||
* Treatment is done in a pre-emptive manner to prevent bleeding, reduce tumor size or slow its growth. Percutaneous [[Therapeutic embolization|embolization]] (which may present with postembolization syndrome) and nephron-sparing surgical resection are possible treatments.<ref name=":0" /> | |||
== | === Subependymal Giant Cell Astrocytoma === | ||
* Surgical resection is the most performed treatment, but may complicate with incomplete resection, hemorrhage, infection and cerebrospinal fluid obstruction.<ref name=":0" /> | |||
=== Skin Lesions === | |||
For TSC-associated skin lesions, the following surgical treatments may be performed: | |||
* Ablation with pulse laser dye or [[CO2]]; | |||
* Surgery | |||
==References== | ==References== | ||
Latest revision as of 17:58, 23 June 2020
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Tuberous sclerosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Tuberous sclerosis surgery On the Web |
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American Roentgen Ray Society Images of Tuberous sclerosis surgery |
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Risk calculators and risk factors for Tuberous sclerosis surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: José Eduardo Riceto Loyola Junior, M.D.[2]
Overview
Surgical options have been historically the only way to treat the TSC-associated complications, but with the introduction of the mTOR inhibitors they have been left for more severe or refractory complications.
Surgical Treatment
Epilepsy
- Vagal nerve stimulation or surgical resection of CNS lesion responsible for the epilepsy may be used.[1]
Angiomyolipoma
- Treatment is done in a pre-emptive manner to prevent bleeding, reduce tumor size or slow its growth. Percutaneous embolization (which may present with postembolization syndrome) and nephron-sparing surgical resection are possible treatments.[1]
Subependymal Giant Cell Astrocytoma
- Surgical resection is the most performed treatment, but may complicate with incomplete resection, hemorrhage, infection and cerebrospinal fluid obstruction.[1]
Skin Lesions
For TSC-associated skin lesions, the following surgical treatments may be performed:
- Ablation with pulse laser dye or CO2;
- Surgery