Pulmonary atresia medical therapy: Difference between revisions

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{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], {{CZ}}; '''Assistant Editor(s)-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu]
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], {{CZ}}; '''Assistant Editor(s)-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu]


==Medical Therapy==
===Medical Therapy===


* Medical therapy in new born with Pulmonary atresia serves only as a bridge to the surgical treatment. It is temporarily and definitive treatment is only surgical
* Medical therapy in newborns with Pulmonary atresia serves only as a bridge to surgical treatment. It is temporarily and definitive treatment is only surgical.
* It is targeted to keep the ductus arteriosus open that otherwise will close in 48 hr. An IV medication called prostaglandin E1 is used for to keep the ductus arteriosus open and gives time while the new born will be prepared for the definitive treatment. Blood circulates from the aorta to the pulmonary artery via this ductus and get oxygenated in the lungs.  
* It is targeted to keep the ductus arteriosus open that otherwise will close in 48 hr. An IV medication called prostaglandin E1 is used to keep the ductus arteriosus open and gives time while the newborn will be prepared for the definitive treatment. Blood circulates from the aorta to the pulmonary artery via this ductus and gets oxygenated in the lungs.
*Other short term strategy is keepin the opening between the right and left atrium patent ( foramen ovale ). This process is called "Balloon atrial septostomy" done via Cardiac Catheterization. A guided wire with the tip of balloon on it is inserted via vein and advanced to the right side of the heart. reaching the foramen ovale. The balloon tip is inflated and adjusted at the opening and the wire is removed This opening will shunt the blood from the right atrium to the left, to the aorta and via ductus arterosus to the pulmonary artery and then to the lungs for proper oxygenation.  
* Another short term strategy is keeping the opening between the right and left atrium patent ( foramen ovale ). This process is called "Balloon atrial septostomy" done via Cardiac Catheterization. A guided wire with the tip of the balloon on it is inserted via vein and advanced to the right side of the heart. reaching the foramen ovale. The balloon tip is inflated and adjusted at the opening and the wire is removed This opening will shunt the blood from the right atrium to the left, to the aorta, and via ductus arterosus to the pulmonary artery and then to the lungs for proper oxygenation.
*It should be kept in mind these procedure ONLY are the short term management and eventually new born will need surgery. [https://my.clevelandclinic.org/health/diseases/14779-pulmonary-atresia/management-and-treatment#:~:text=Usually%2C%20the%20child%20will%20need,the%20ductus%20arteriosus%20from%20closing.]
* It should be kept in mind these procedures ONLY are the short term management and eventually newborn will need surgery. <ref>{{cite web |url=https://www.cdc.gov/ncbddd/heartdefects/pulmonaryatresia.html |title=Congenital Heart Defects - Facts about Pulmonary Atresia &#124; CDC |format= |work= |accessdate=}}</ref> <ref> {{cite web |url=http://www.heart.org/idc/groups/heart-public/@wcm/@hcm/documents/downloadable/ucm_307665.pdf |title=www.heart.org |format= |work= |accessdate=}} </ref> <ref>{{cite web |url=https://www.nhlbi.nih.gov/health-topics/congenital-heart-defects |title=Congenital Heart Defects &#124; National Heart, Lung, and Blood Institute (NHLBI) |format= |work= |accessdate=}}</ref>
 
 
 
 
'''Surgical:''' [[Pulmonary atresia surgery|Surgery]]
 
[[Pulmonary atresia primary prevention|Primary Prevention]] | [[Pulmonary atresia secondary prevention|Secondary Prevention]] | [[Pulmonary atresia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Pulmonary atresia future or investigational therapies|Future or Investigational Therapies]]


==References==
==References==

Latest revision as of 03:57, 6 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2], Cafer Zorkun, M.D., Ph.D. [3]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [4]

Medical Therapy

  • Medical therapy in newborns with Pulmonary atresia serves only as a bridge to surgical treatment. It is temporarily and definitive treatment is only surgical.
  • It is targeted to keep the ductus arteriosus open that otherwise will close in 48 hr. An IV medication called prostaglandin E1 is used to keep the ductus arteriosus open and gives time while the newborn will be prepared for the definitive treatment. Blood circulates from the aorta to the pulmonary artery via this ductus and gets oxygenated in the lungs.
  • Another short term strategy is keeping the opening between the right and left atrium patent ( foramen ovale ). This process is called "Balloon atrial septostomy" done via Cardiac Catheterization. A guided wire with the tip of the balloon on it is inserted via vein and advanced to the right side of the heart. reaching the foramen ovale. The balloon tip is inflated and adjusted at the opening and the wire is removed This opening will shunt the blood from the right atrium to the left, to the aorta, and via ductus arterosus to the pulmonary artery and then to the lungs for proper oxygenation.
  • It should be kept in mind these procedures ONLY are the short term management and eventually newborn will need surgery. [1] [2] [3]



Surgical: Surgery

Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

References

  1. "Congenital Heart Defects - Facts about Pulmonary Atresia | CDC".
  2. "www.heart.org" (PDF).
  3. "Congenital Heart Defects | National Heart, Lung, and Blood Institute (NHLBI)".


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