Aspiration pneumonia laboratory tests: Difference between revisions

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==Overview==
==Overview==
While [[chest X-ray]] and [[pulse oximetry]] are routine tests among all patients with suspected aspiration pneumonia, additional laboratory tests (such as blood culture and gram sputum, sputum blood culture and gram stain) are optional tests unless their results might alter the treatment plan.
Different laboratory tests might be used in patients with aspiration pneumonia. [[Sputum]] analysis including [[Gram staining|gram stain]] and culture must be done in patients with [[cough]]. [[Arterial blood gas|ABG]] may show acute [[hypoxemia]] and decreased mixed venous [[oxygen saturation]]. [[Complete blood count|CBC]] shows [[leukocytosis]] with left shift or [[leukopenia]], [[anemia]], or [[thrombocytopenia]].


==Laboratory Tests==
==Laboratory Tests==
===Routine Tests===
===Routine Tests===
Findings in routine blood tests are based on the severity of the disease and the cause, they can include the following:<ref name="SolomonWunderink2014">{{cite journal|last1=Solomon|first1=Caren G.|last2=Wunderink|first2=Richard G.|last3=Waterer|first3=Grant W.|title=Community-Acquired Pneumonia|journal=New England Journal of Medicine|volume=370|issue=6|year=2014|pages=543–551|issn=0028-4793|doi=10.1056/NEJMcp1214869}}</ref>
Findings in routine blood tests are based on the severity of the disease and the cause, they can include the following:<ref name="SolomonWunderink2014">{{cite journal|last1=Solomon|first1=Caren G.|last2=Wunderink|first2=Richard G.|last3=Waterer|first3=Grant W.|title=Community-Acquired Pneumonia|journal=New England Journal of Medicine|volume=370|issue=6|year=2014|pages=543–551|issn=0028-4793|doi=10.1056/NEJMcp1214869}}</ref>
*[[Leukocytosis]] with left shift (in cases of bacterial pneumonia)
*[[Complete blood count|CBC]] shows:
*[[Leukopenia]] (in cases of atypical pneumonia)
**[[Leukocytosis]] with left shift (in cases of bacterial pneumonia)
*[[Eosinophilia]] (in cases of [[eosinophilic pneumonia]])
**[[Leukopenia]] (in cases of atypical pneumonia)
*[[Anemia]]
**[[Eosinophilia]] (in cases of [[eosinophilic pneumonia]])
**[[Anemia]]
**[[Thrombocytopenia]]
*[[Hyponatremia]]
*[[Hyponatremia]]
*[[Thrombocytopenia]]
*Elevated [[BUN]]
*Elevated [[BUN]]
*Findings of lactic acidosis (decreased HCO<sub>3</sub>, increased [[lactic acid]] levels)
*[[ABG]] may show:
*[[ABG]]: may show [[hypoxia]] and/or hypercapnea
**Acute [[hypoxemia]]
**Normal to low partial pressure of [[carbon dioxide]]
**Decreased mixed venous oxygen saturation if a patient is in [[Sepsis|septic shock]]
**Decreased [[Bicarbonate|HCO<sub>3</sub>]]
**High [[Lactic acidosis|lactate level]] if a patient is in [[Sepsis|septic shock]]


===Sputum Gram Stain and Culture===
===Sputum Gram Stain and Culture===
*Sputum samples should be obtained in all patients with productive [[cough]].
*[[Sputum]] samples should be obtained in all patients with productive [[cough]].
*Gram-stain and culture should be performed to assess the causative agent and guide the therapy.
*[[Gram staining|Gram stain]] and culture should be performed to assess the causative agent and guide the therapy.
*In approximately 80% of cases of [[pneumococcal pneumonia]] the sputum culture is positive.<ref name="MusherThorner2014">{{cite journal|last1=Musher|first1=Daniel M.|last2=Thorner|first2=Anna R.|title=Community-Acquired Pneumonia|journal=New England Journal of Medicine|volume=371|issue=17|year=2014|pages=1619–1628|issn=0028-4793|doi=10.1056/NEJMra1312885}}</ref>
*However, the general yield of a sputum sample does not exceed 50-60%.


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Medicine]]
[[Category:Pulmonology]]
[[Category:Up-To-Date]]
[[Category:Emergency medicine]]

Latest revision as of 20:29, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Different laboratory tests might be used in patients with aspiration pneumonia. Sputum analysis including gram stain and culture must be done in patients with cough. ABG may show acute hypoxemia and decreased mixed venous oxygen saturation. CBC shows leukocytosis with left shift or leukopenia, anemia, or thrombocytopenia.

Laboratory Tests

Routine Tests

Findings in routine blood tests are based on the severity of the disease and the cause, they can include the following:[1]

Sputum Gram Stain and Culture

  • Sputum samples should be obtained in all patients with productive cough.
  • Gram stain and culture should be performed to assess the causative agent and guide the therapy.

References

  1. Solomon, Caren G.; Wunderink, Richard G.; Waterer, Grant W. (2014). "Community-Acquired Pneumonia". New England Journal of Medicine. 370 (6): 543–551. doi:10.1056/NEJMcp1214869. ISSN 0028-4793.