Brucellosis history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Brucellosis}} | {{Brucellosis}} | ||
{{CMG}}; {{AE}} {{RT}} {{DL}} | {{CMG}}; {{AE}} {{RT}} {{DL}} {{VD}} | ||
==Overview== | ==Overview== | ||
Brucellosis can present with diverse clinical presentation which include systemic [[flu]]-like symptoms and symptoms due to focal involvement of organs by the [[bacteria]]. | |||
==Symptoms== | ==Symptoms== | ||
Patients with [[brucellosis]], can present with diverse clinical presentation which include systemic flu-like symptoms and symptoms due to focal involvement of organs by the bacteria:<ref>Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017 | |||
</ref><ref>Colmenero JD, Reguera JM, Martos F, Sánchez-De-Mora D, Delgado M, Causse M; et al. (1996). [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8699960 "Complications associated with Brucella melitensis infection: a study of 530 cases."]. ''Medicine (Baltimore)''. '''75''' (4): 195–211. PMID [http://www.ncbi.nlm.nih.gov/pubmed/8699960 8699960]</ref><ref>Mantur BG, Amarnath SK, Shinde RS (2007). [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17901634 "Review of clinical and laboratory features of human brucellosis."]. ''Indian J Med Microbiol''. '''25''' (3): 188–202. PMID [http://www.ncbi.nlm.nih.gov/pubmed/17901634 17901634]</ref><ref>Pappas G, Akritidis N, Bosilkovski M, Tsianos E (2005). [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15930423 "Brucellosis."]. ''N Engl J Med''. '''352''' (22): 2325–36. PMID [http://www.ncbi.nlm.nih.gov/pubmed/15930423 15930423]. </ref><ref name="pmid23236528">{{cite journal| author=Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J| title=Clinical manifestations of human brucellosis: a systematic review and meta-analysis. | journal=PLoS Negl Trop Dis | year= 2012 | volume= 6 | issue= 12 | pages= e1929 | pmid=23236528 | doi=10.1371/journal.pntd.0001929 | pmc=3516581 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23236528 }}</ref><ref>Young EJ (1995). [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7546364 "Brucellosis: current epidemiology, diagnosis, and management."]. ''Curr Clin Top Infect Dis''. '''15''': 115–28. PMID [http://www.ncbi.nlm.nih.gov/pubmed/7546364 7546364]</ref><ref>Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.</ref><ref name="pmid21623056">{{cite journal| author=Zamani A, Kooraki S, Mohazab RA, Zamani N, Matloob R, Hayatbakhsh MR et al.| title=Epidemiological and clinical features of Brucella arthritis in 24 children. | journal=Ann Saudi Med | year= 2011 | volume= 31 | issue= 3 | pages= 270-3 | pmid=21623056 | doi=10.4103/0256-4947.81543 | pmc=3119967 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21623056 }}</ref><ref>Mousa AM, Bahar RH, Araj GF, Koshy TS, Muhtaseb SA, al-Mudallal DS; et al. (1990). [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2330811 "Neurological complications of brucella spondylitis."]. ''Acta Neurol Scand''. '''81''' (1): 16–23. PMID [http://www.ncbi.nlm.nih.gov/pubmed/2330811 2330811]</ref><ref>Pappas G, Bosilkovski M, Akritidis N, Mastora M, Krteva L, Tsianos E (2003). [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13130417 "Brucellosis and the respiratory system."]. ''Clin Infect Dis''. '''37''' (7): e95–9. PMID [http://www.ncbi.nlm.nih.gov/pubmed/13130417 13130417]. [[Digital object identifier|doi]]:[http://dx.doi.org/10.1086%2F378125 10.1086/378125]</ref><ref>Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.</ref><ref name="pmid18162038">{{cite journal| author=Ariza J, Bosilkovski M, Cascio A, Colmenero JD, Corbel MJ, Falagas ME et al.| title=Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. | journal=PLoS Med | year= 2007 | volume= 4 | issue= 12 | pages= e317 | pmid=18162038 | doi=10.1371/journal.pmed.0040317 | pmc=2222927 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18162038 }}</ref> | |||
{| class="wikitable" | {| class="wikitable" | ||
! colspan="2" |Brucellosis | ! colspan="2" |Brucellosis history and symptoms | ||
|- | |- | ||
|Acute brucellosis | |Acute brucellosis | ||
| | |Systemic symptoms | ||
Systemic symptoms | |||
*[[Undulant fever]] | *[[Undulant fever]] | ||
**High fever spikes usually occur every afternoon | **High fever spikes usually occur every afternoon | ||
| Line 23: | Line 23: | ||
*[[Weakness]] | *[[Weakness]] | ||
*[[Weight loss]] | *[[Weight loss]] | ||
[[Clinical depression|Depression]] | |||
* [[Clinical depression|Depression]] | |||
Focal organ wise symptoms: | Focal organ wise symptoms: | ||
* Muscuoskeletal: Joint pain(Commonly in low back and larger joints of lower limbs) | * Muscuoskeletal: [[Joint pain]](Commonly in low back and larger joints of [[lower limbs]]) | ||
* Genitourinary: Pain in the genital region and increase in frequency of urination/burning senation while passing urine(2 to 20 percent of cases) | * [[Genitourinary system|Genitourinary]]: Pain in the [[Genital|genital region]] and increase in frequency of [[urination]]/[[Burning during urination|burning senation]] while passing [[urine]](2 to 20 percent of cases) | ||
* Pulmonary: Cough, chest pain, difficulty in breathing(pulmonary involvement present upto 7 percent of patients) | * [[Pulmonary]]: [[Cough]], [[chest pain]], [[difficulty in breathing]](pulmonary involvement present upto 7 percent of patients) | ||
* Gastrointestinal: Abdominal pain and symptoms of [[hepatitis]] can be present in 3-6 percent of presenting patients | * [[Gastrointestinal]]: [[Abdominal pain]] and symptoms of [[hepatitis]] can be present in 3-6 percent of presenting patients | ||
* Neurological: Headache, confusion or altered sensorium(meningoencephalitits), loss of sensation(radiculopathies or neuritis involving the cranial or peripheral nerves) can be present in 2-7 percent of patients | * [[Neurological]]: [[Headache]], [[confusion]] or [[Altered mental state|altered sensorium]] (meningoencephalitits), [[loss of sensation]] ([[Radiculopathy|radiculopathies]] or [[neuritis]] involving the [[cranial]] or [[peripheral nerves]]) can be present in 2-7 percent of patients | ||
* Cardiovascular: Chest pain is rare cardiovascular feature of brucellosis | * [[Cardiovascular]]: [[Chest pain]] is rare cardiovascular feature of brucellosis | ||
* Ocular: Difficulty in vision and | * Ocular: Difficulty in [[vision]] and dimenision of vision | ||
* Dermatology: Rash, ulcer or tender swelling can present with brucellosis upto 10 percent of | * Dermatology: [[Rash]], [[ulcer]] or [[Tenderness (medicine)|tender]] [[swelling]] can present with [[brucellosis]] upto 10 percent of patients | ||
|- | |- | ||
|Relapse | |Relapse | ||
| | | | ||
* [[Relapse]] occurs in 5 to 15 percent of patient usually in first 6 months following treatment, although in rare cases it may even occur in up to 12 months of treatment.<ref>Ariza J, Bosilkovski M, Cascio A, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med 2007; 4:e317.</ref><ref>Ariza J, Corredoira J, Pallares R, et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 1995; 20:1241.</ref> | |||
Relapse occurs in 5 to 15 percent of patient usually in first 6 months following treatment, although in rare cases it may even occur in up to 12 months of treatment.<ref>Ariza J, Bosilkovski M, Cascio A, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med 2007; 4:e317.</ref><ref>Ariza J, Corredoira J, Pallares R, et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 1995; 20:1241.</ref> | * General well-being and changes in body [[weight]] help in diagnosis of relapse. | ||
|- | |- | ||
|Chronic Brucellosis | |Chronic Brucellosis | ||
|Presence of clinical | |Presence of clinical manifestations for more then one year after established diagnosis of [[brucellosis]] is considered as chronic [[brucellosis]]. | ||
Clinical manifestations include:<ref name="pmid7546364">{{cite journal| author=Young EJ| title=Brucellosis: current epidemiology, diagnosis, and management. | journal=Curr Clin Top Infect Dis | year= 1995 | volume= 15 | issue= | pages= 115-28 | pmid=7546364 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7546364 }}</ref> <ref name="pmid19420176">{{cite journal| author=Castaño MJ, Solera J| title=Chronic brucellosis and persistence of Brucella melitensis DNA. | journal=J Clin Microbiol | year= 2009 | volume= 47 | issue= 7 | pages= 2084-9 | pmid=19420176 | doi=10.1128/JCM.02159-08 | pmc=2708509 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19420176 }}</ref> | |||
* [[Fatigue]] | |||
* [[Arthralgia]] | |||
Uveitis: patients complains of difficulty of vision | * [[Malaise]] | ||
* [[Myalgia]] | |||
Spondylitis, osteomyelitis, Arthralgias: patients complains of pain in joints or joint movement | * [[Uveitis]]: patients complains of difficulty of [[vision]] | ||
* [[Spondylitis]], [[Osteomyelitis|osteomyelitis,]] [[Arthralgias]]: patients complains of pain in joints or [[joint]] movement | |||
Intermittent sweating | * Intermittent [[sweating]] | ||
|} | |} | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category: | |||
[[Category: | [[Category:Disease]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
[[Category:Pulmonology]] | |||
[[Category:Hepatology]] | |||
[[Category:Rheumatology]] | |||
[[Category:Nephrology]] | |||
[[Category:Emergency medicine]] | |||
[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
Latest revision as of 20:44, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Danitza Lukac Vishal Devarkonda, M.B.B.S[3]
Overview
Brucellosis can present with diverse clinical presentation which include systemic flu-like symptoms and symptoms due to focal involvement of organs by the bacteria.
Symptoms
Patients with brucellosis, can present with diverse clinical presentation which include systemic flu-like symptoms and symptoms due to focal involvement of organs by the bacteria:[1][2][3][4][5][6][7][8][9][10][11][12]
| Brucellosis history and symptoms | |
|---|---|
| Acute brucellosis | Systemic symptoms
Focal organ wise symptoms:
|
| Relapse | |
| Chronic Brucellosis | Presence of clinical manifestations for more then one year after established diagnosis of brucellosis is considered as chronic brucellosis.
Clinical manifestations include:[15] [16]
|
References
- ↑ Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017
- ↑ Colmenero JD, Reguera JM, Martos F, Sánchez-De-Mora D, Delgado M, Causse M; et al. (1996). "Complications associated with Brucella melitensis infection: a study of 530 cases.". Medicine (Baltimore). 75 (4): 195–211. PMID 8699960
- ↑ Mantur BG, Amarnath SK, Shinde RS (2007). "Review of clinical and laboratory features of human brucellosis.". Indian J Med Microbiol. 25 (3): 188–202. PMID 17901634
- ↑ Pappas G, Akritidis N, Bosilkovski M, Tsianos E (2005). "Brucellosis.". N Engl J Med. 352 (22): 2325–36. PMID 15930423.
- ↑ Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J (2012). "Clinical manifestations of human brucellosis: a systematic review and meta-analysis". PLoS Negl Trop Dis. 6 (12): e1929. doi:10.1371/journal.pntd.0001929. PMC 3516581. PMID 23236528.
- ↑ Young EJ (1995). "Brucellosis: current epidemiology, diagnosis, and management.". Curr Clin Top Infect Dis. 15: 115–28. PMID 7546364
- ↑ Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.
- ↑ Zamani A, Kooraki S, Mohazab RA, Zamani N, Matloob R, Hayatbakhsh MR; et al. (2011). "Epidemiological and clinical features of Brucella arthritis in 24 children". Ann Saudi Med. 31 (3): 270–3. doi:10.4103/0256-4947.81543. PMC 3119967. PMID 21623056.
- ↑ Mousa AM, Bahar RH, Araj GF, Koshy TS, Muhtaseb SA, al-Mudallal DS; et al. (1990). "Neurological complications of brucella spondylitis.". Acta Neurol Scand. 81 (1): 16–23. PMID 2330811
- ↑ Pappas G, Bosilkovski M, Akritidis N, Mastora M, Krteva L, Tsianos E (2003). "Brucellosis and the respiratory system.". Clin Infect Dis. 37 (7): e95–9. PMID 13130417. doi:10.1086/378125
- ↑ Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.
- ↑ Ariza J, Bosilkovski M, Cascio A, Colmenero JD, Corbel MJ, Falagas ME; et al. (2007). "Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations". PLoS Med. 4 (12): e317. doi:10.1371/journal.pmed.0040317. PMC 2222927. PMID 18162038.
- ↑ Ariza J, Bosilkovski M, Cascio A, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med 2007; 4:e317.
- ↑ Ariza J, Corredoira J, Pallares R, et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 1995; 20:1241.
- ↑ Young EJ (1995). "Brucellosis: current epidemiology, diagnosis, and management". Curr Clin Top Infect Dis. 15: 115–28. PMID 7546364.
- ↑ Castaño MJ, Solera J (2009). "Chronic brucellosis and persistence of Brucella melitensis DNA" Check
|url=value (help). J Clin Microbiol. 47 (7): 2084–9. doi:10.1128/JCM.02159-08. PMC 2708509. PMID 19420176.