Celiac disease diagnostic criteria: Difference between revisions
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==Overview== | ==Overview== | ||
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met: typical symptoms (chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation | The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the [[HLA|HLA genotype]] is not performed) diagnostic criteria are met: typical [[symptoms]] ([[chronic diarrhea]], [[chronic abdominal pain]], [[malabsorption]], [[bloating]], [[constipation]], [[failure to thrive]]/[[weight loss]], [[anorexia]], [[vomiting]], [[Gastroesophageal reflux disease|GERD]]), [[serum]] positivity for [[IgA|Ig A]] [[autoantibodies]] at high titer, [[HLA-DQ2]] or [[HLA-DQ8]] [[Genotype|genotypes]], celiac [[enteropathy]] on [[small intestinal]] [[biopsy]], and response to [[gluten-free diet]]. | ||
==Diagnostic criteria== | ==Diagnostic criteria== | ||
The diagnosis of celiac disease | The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the [[HLA]] genotype is not performed) diagnostic criteria are met:<ref name="pmid23609613">{{cite journal |vauthors=Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA |title=ACG clinical guidelines: diagnosis and management of celiac disease |journal=Am. J. Gastroenterol.|pmid=23609613 |pmc=3706994 |doi=10.1038/ajg.2013.79 |url=}}</ref><ref name="pmid2205160">{{cite journal |vauthors= |title=Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition |journal=Arch. Dis. Child. |volume=65 |issue=8 |pages=909–11 |year=1990 |pmid=2205160 |pmc=1792502 |doi= |url=}}</ref> | ||
* Typical symptoms ( | * Typical symptoms ([[chronic diarrhea]], [[chronic abdominal pain]], [[malabsorption]], [[bloating]], [[constipation]] (more commonly in children), [[failure to thrive]]/[[weight loss]], [[anorexia]], [[vomiting]], [[GERD]]) | ||
* Serum positivity for | * [[Serum]] positivity for [[Immunoglobulin A|IgA]] [[autoantibodies]] at high titer | ||
* HLA-DQ2 or HLA-DQ8 genotypes | * [[HLA-DQ2]] or [[HLA-DQ8]] [[Genotype|genotypes]] | ||
* Celiac enteropathy at the small intestinal biopsy | * Celiac [[enteropathy]] at the [[Small intestine|small intestinal]] [[biopsy]] | ||
* Response to gluten-free diet | * Response to [[gluten-free diet]] | ||
{{familytree/start |summary=Sample 1}} | {{familytree/start |summary=Sample 1}} | ||
{{familytree | | | | | | | | A01 |A01=Diagnostic criteria met<br>Symptomatic patients<br> High risk population}} | {{familytree | | | | | | | | A01 |A01=♦ Diagnostic criteria met<br>♦ Symptomatic patients<br>♦ High risk population}} | ||
{{familytree | | | | | | | | |!| | | | | | | | }} | {{familytree | | | | | | | | |!| | | | | | | | }} | ||
{{familytree | | | | | | | | Z01 | | | | | | |Z01=Serology }} | {{familytree | | | | | | | | Z01 | | | | | | |Z01=Serology }} | ||
| Line 33: | Line 33: | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Malnutrition]] | [[Category:Malnutrition]] | ||
[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Up-To-Date]] | [[Category:Up-To-Date]] | ||
Latest revision as of 20:50, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met: typical symptoms (chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation, failure to thrive/weight loss, anorexia, vomiting, GERD), serum positivity for Ig A autoantibodies at high titer, HLA-DQ2 or HLA-DQ8 genotypes, celiac enteropathy on small intestinal biopsy, and response to gluten-free diet.
Diagnostic criteria
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met:[1][2]
- Typical symptoms (chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation (more commonly in children), failure to thrive/weight loss, anorexia, vomiting, GERD)
- Serum positivity for IgA autoantibodies at high titer
- HLA-DQ2 or HLA-DQ8 genotypes
- Celiac enteropathy at the small intestinal biopsy
- Response to gluten-free diet
| ♦ Diagnostic criteria met ♦ Symptomatic patients ♦ High risk population | |||||||||||||||||||||||||||||||||
| Serology | |||||||||||||||||||||||||||||||||
| Positive | Negative | ||||||||||||||||||||||||||||||||
| Biopsy | Celiac disease is ruled out consider other diagnosis | ||||||||||||||||||||||||||||||||
| Positive | Negative | ||||||||||||||||||||||||||||||||
| Celiac disease | Reevaluate HLA DQ2 and DQ8 other diagnosis | ||||||||||||||||||||||||||||||||
References
- ↑ Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. "ACG clinical guidelines: diagnosis and management of celiac disease". Am. J. Gastroenterol. doi:10.1038/ajg.2013.79. PMC 3706994. PMID 23609613.
- ↑ "Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition". Arch. Dis. Child. 65 (8): 909–11. 1990. PMC 1792502. PMID 2205160.