Chronic diarrhea medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
[[Antidiarrheal]] drugs can be broadly defined as agents that minimize the [[symptoms]] of diarrhea by improving stool [[Consistency (statistics)|consistency]], reducing stool [[frequency]], or reducing [[Human feces|stool weight.]]<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866 }} </ref> | [[Antidiarrheal]] drugs can be broadly defined as agents that minimize the [[symptoms]] of diarrhea by improving stool [[Consistency (statistics)|consistency]], reducing stool [[frequency]], or reducing [[Human feces|stool weight]]. [[Chronic diarrhea]] is a common symptom of many conditions. In order to appropriately treat [[chronic diarrhea]], the underlying causes must be identified and treated and, in most cases, the [[chronic diarrhea]] will resolve.<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866 }} </ref> | ||
==Medical Therapy== | ==Medical Therapy== | ||
For the treatment of the most common causes of [[chronic diarrhea]], please click below: | For the treatment of the most common causes of [[chronic diarrhea]], please click below: | ||
*'''Inflammatory diarrhea''' | *'''Inflammatory diarrhea''' | ||
**[[Crohn's disease medical therapy#Medical Therapy| | **[[Crohn's disease medical therapy#Medical Therapy|Crohn's disease]] | ||
**[[Ulcerative colitis medical therapy#Medical Therapy|Ulcerative | **[[Ulcerative colitis medical therapy#Medical Therapy|Ulcerative colitis]] | ||
**[[Tuberculosis medical therapy#Medical Therapy|Tuberculosis]] | **[[Tuberculosis medical therapy#Medical Therapy|Tuberculosis]] | ||
**[[Strongyloidiasis medical therapy#Medical Therapy|Strongyloidiasis]] | **[[Strongyloidiasis medical therapy#Medical Therapy|Strongyloidiasis]] | ||
**[[Ischemic colitis medical therapy#Medical Therapy|Ischemic | **[[Ischemic colitis medical therapy#Medical Therapy|Ischemic colitis]] | ||
*'''Watery diarrhea''' | *'''Watery diarrhea''' | ||
**[[Celiac disease medical therapy#Medical Therapy|Celiac sprue]] | **[[Celiac disease medical therapy#Medical Therapy|Celiac sprue]] | ||
**[[Chronic pancreatitis medical therapy#Medical Therapy|Chronic pancreatitis]] | **[[Chronic pancreatitis medical therapy#Medical Therapy|Chronic pancreatitis]] | ||
**[[Lactose intolerance medical therapy#Medical Therapy|Lactose | **[[Lactose intolerance medical therapy#Medical Therapy|Lactose intolerance]] | ||
**[[Whipple's disease medical therapy#Medical Therapy|Whipple's disease]] | **[[Whipple's disease medical therapy#Medical Therapy|Whipple's disease]] | ||
**[[Cholera medical therapy#Medical Therapy|Cholera]] | **[[Cholera medical therapy#Medical Therapy|Cholera]] | ||
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**[[Small bowel bacterial overgrowth syndrome#Treatment|Small bowel bacterial overgrowth syndrome]] | **[[Small bowel bacterial overgrowth syndrome#Treatment|Small bowel bacterial overgrowth syndrome]] | ||
Below are some of the [[drugs]] that can be used in the symptomatic treatment of chronic diarrhea and | Below are some of the [[drugs]] that can be used in the symptomatic treatment of chronic [[diarrhea]] and their mechanisms of action. Some [[drugs]] have numerous mechanisms of action and can thus be found under more than one section. It is important to know that these [[drugs]] are used for the [[symptomatic]] treatment of chronic [[diarrhea]]. In order to appropriately treat chronic [[diarrhea]], the underlying cause of the [[disease]] must be identified.<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866 }} </ref> | ||
'''Inhibitors of intestinal transit time''' | '''Inhibitors of intestinal transit time''' | ||
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**[[Lanreotide]] | **[[Lanreotide]] | ||
**[[Pasireotide]] | **[[Pasireotide]] | ||
*[[Enterocyte]] apical membrane chloride channel inhibitors | *[[Enterocyte]] apical membrane [[chloride channel]] inhibitors | ||
**[[Crofelemer]] | **[[Crofelemer]] | ||
*[[Berberine]] | *[[Berberine]] | ||
*[[Calcium channel blockers]] | *[[Calcium channel blockers]] | ||
**[[Nifedipine]] | **[[Nifedipine]] | ||
*Calmodulin inhibitors | *[[Calmodulin]] inhibitors | ||
**[[Chlorpromazine]] | **[[Chlorpromazine]] | ||
**[[Trifluoperazine]] | **[[Trifluoperazine]] | ||
*[[Calcium-sensing receptor|Calcium-sensing receptor ligands]] | *[[Calcium-sensing receptor|Calcium-sensing receptor ligands]] | ||
*[[Nicotinic acid]] | *[[Nicotinic acid]] | ||
*[[Lithium]] | *[[Lithium]] | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Emergency medicine]] | |||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Pediatrics]] | |||
Latest revision as of 20:57, 29 July 2020
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Chronic diarrhea Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
Antidiarrheal drugs can be broadly defined as agents that minimize the symptoms of diarrhea by improving stool consistency, reducing stool frequency, or reducing stool weight. Chronic diarrhea is a common symptom of many conditions. In order to appropriately treat chronic diarrhea, the underlying causes must be identified and treated and, in most cases, the chronic diarrhea will resolve.[1]
Medical Therapy
For the treatment of the most common causes of chronic diarrhea, please click below:
- Inflammatory diarrhea
- Watery diarrhea
Below are some of the drugs that can be used in the symptomatic treatment of chronic diarrhea and their mechanisms of action. Some drugs have numerous mechanisms of action and can thus be found under more than one section. It is important to know that these drugs are used for the symptomatic treatment of chronic diarrhea. In order to appropriately treat chronic diarrhea, the underlying cause of the disease must be identified.[1]
Inhibitors of intestinal transit time
- Opiates
- Encephalinase inhibitor
- 5-HT3-receptor antagonist
- α2-Adrenergic agonist
- Somatostatin and analogs
- Calcium channel blocker
Pro-absorptive agents
Antisecretory drugs
- Somatostatin and analogs
- Enterocyte apical membrane chloride channel inhibitors
- Berberine
- Calcium channel blockers
- Calmodulin inhibitors
- Calcium-sensing receptor ligands
- Nicotinic acid
- Lithium
- Zinc
- Bismuth
- Nonsteroidal antiinflammatory drugs
- Corticosteroids
- Teduglutide
Intraluminal agents
- Adsorbents
- Clays
- Bile acid-binding resins
- Fiber
References
- ↑ 1.0 1.1 Schiller LR (1995). "Review article: anti-diarrhoeal pharmacology and therapeutics". Aliment Pharmacol Ther. 9 (2): 87–106. PMID 7605866.