Chronic neutrophilic leukemia diagnostic study of choice: Difference between revisions

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Latest revision as of 20:57, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

World health organization (WHO) introduces criteria for the diagnosis of chronic neutrophilic leukemia (CNL) that are based on the laboratory finding of peripheral blood cells, bone marrow, cytogenic mutation, and differential diagnosis.

Diagnostic Study of Choice

Study of choice

The diagnosis of CNL is based on the WHO criteria, which include:^[1]

World Health Organization (WHO) Criteria for CNL diagnosis
1. Peripheral blood White blood cells (WBC) ≥25 ×10⁹/L:	Segmented neutrophils plus band forms ≥80% of WBC Neutrophil precursors <10% of WBC Myeloblasts rarely observed Monocyte count <1 ×10⁹/L No dysgranulopoies.
2. Hypercellular bone marrow:	Neutrophil granulocytes increased in percentage and number Normal neutrophil maturation Myeloblasts <5% of nucleated cells
3. Not meeting WHO criteria for:	BCR-ABL1+ chronic myeloid leukemia, Polycythemia vera Essential thrombocythemia Primary myelofibrosis
4. No rearrangement of:	PDGFRA PDGFRB FGFR1 PCM1-JAK2
5.Presence of CSF3RT618I or other activating CSF3R mutation or In the absence of a CSFR3R mutation, persistent neutrophilia (at least 3 months), splenomegaly, and no identifiable cause of reactive neutrophilia including the absence of a plasma cell neoplasm or, if present, demonstration of clonality of myeloid cells by cytogenetic or molecular studies.

References

↑ Arber, D. A.; Orazi, A.; Hasserjian, R.; Thiele, J.; Borowitz, M. J.; Le Beau, M. M.; Bloomfield, C. D.; Cazzola, M.; Vardiman, J. W. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–2405. doi:10.1182/blood-2016-03-643544. ISSN 0006-4971.

Template:WH Template:WS ]

[ArberOrazi2016-1] Arber, D. A.; Orazi, A.; Hasserjian, R.; Thiele, J.; Borowitz, M. J.; Le Beau, M. M.; Bloomfield, C. D.; Cazzola, M.; Vardiman, J. W. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–2405. doi:10.1182/blood-2016-03-643544. ISSN 0006-4971.

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Chronic neutrophilic leukemia}}
-{{CMG}}; {{AE}}
+{{CMG}}; {{AE}} {{Homa}}; {{GRR}} {{Nat}}
 == Overview ==
 [[World health organization]] [[(WHO)]] introduces [[criteria]] for the diagnosis of chronic neutrophilic leukemia (CNL) that are based on the [[laboratory]] finding of [[peripheral blood cells]], [[bone marrow]], cytogenic [[mutation]], and [[differential diagnosis]].
@@ Line 10: / Line 10: @@
 The [[diagnosis]] of CNL is based on the [[WHO]] criteria, which include:<ref name="ArberOrazi2016">{{cite journal|last1=Arber|first1=D. A.|last2=Orazi|first2=A.|last3=Hasserjian|first3=R.|last4=Thiele|first4=J.|last5=Borowitz|first5=M. J.|last6=Le Beau|first6=M. M.|last7=Bloomfield|first7=C. D.|last8=Cazzola|first8=M.|last9=Vardiman|first9=J. W.|title=The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia|journal=Blood|volume=127|issue=20|year=2016|pages=2391–2405|issn=0006-4971|doi=10.1182/blood-2016-03-643544}}</ref>
-{| class="wikitable"
+{|
-|+
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |World Health Organization (WHO) Criteria for CNL diagnosis
-! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |World Health Organization (WHO) Criteria for CNL Diagnosis
 |-
-! style="background: #DCDCDC; text-align: center;" |1. Peripheral blood White blood cells(WBC) ≥25 × 109/L:
+! style="background: #DCDCDC; text-align: center;" |1. [[Peripheral blood]] [[White blood cells]] [[(WBC)]] ≥25 ×10<sup>9</sup>/L:
 | style="background: #F5F5F5;" |
-* Segmented neutrophils plus band forms ≥80% of WBC
+* Segmented [[neutrophils]] plus [[Band cell|band]] forms ≥80% of [[WBC]]
+* [[Neutrophil]] [[Precursor|precursors]] <10% of WBC
-* Neutrophil precursors <10% of WBC
+* [[Myeloblast|Myeloblasts]] rarely observed
+* [[Monocyte]] count <1 ×10<sup>9</sup>/L
-* Myeloblasts rarely observed
-* Monocyte count <1 × 109/L
 * No dysgranulopoies.
 |-
-! style="background: #DCDCDC; text-align: center;" |2. Hypercellular bone marrow:
+! style="background: #DCDCDC; text-align: center;" |2. Hypercellular [[bone marrow]]:
 | style="background: #F5F5F5;" |
-* Neutrophil granulocytes increased in percentage and number
+* [[Neutrophil granulocytes]] increased in percentage and number
+* Normal [[neutrophil]] [[maturation]]
-* Normal neutrophil maturation
+* [[Myeloblast|Myeloblasts]] <5% of [[nucleated]] cells
-* Myeloblasts <5% of nucleated cells
 |-
-! style="background: #DCDCDC; text-align: center;" |3. Not meeting WHO criteria for:
+! style="background: #DCDCDC; text-align: center;" |3. Not meeting [[WHO]] criteria for:
 | style="background: #F5F5F5;" |
-* BCR-ABL1+ chronic myeloid leukemia,
+* BCR-ABL1+ [[chronic myeloid leukemia]],
+* [[Polycythemia vera]]
-* Polycythemia vera
+* [[Essential thrombocythemia]]
-* Essential thrombocythemia,
+* [[Primary myelofibrosis]]
-* Primary myelofibrosis
 |-
-! style="background: #DCDCDC; text-align: center;" |4.No rearrangement of:
+! style="background: #DCDCDC; text-align: center;" |4. No rearrangement of:
-|
+| style="background: #F5F5F5;" |
-* PDGFRA,
+* PDGFRA
-* PDGFRB,
+* [[PDGFRB]]
-* FGFR1,
+* [[FGFR1]]
 * PCM1-JAK2
 |-
-! colspan="2" |5.Presence of CSF3RT618I or other activating CSF3R mutation or
+! colspan="2" style="background: #DCDCDC; text-align: center;" |
-In the absence of a CSFR3R mutation, persistent neutrophilia (at least 3 months), splenomegaly, and no identifiable cause of reactive neutrophilia
+.Presence of CSF3RT618I or other activating [[CSF3R]] [[mutation]] or In the absence of a CSFR3R [[Mutation|mutation,]] persistent [[neutrophilia]] (at least 3 months), [[splenomegaly]], and no identifiable cause of reactive [[neutrophilia]] including the absence of a [[plasma cell neoplasm]] or, if present, demonstration of clonality of [[myeloid cells]] by [[cytogenetic]] or [[molecular]] studies.
-including the absence of a plasma cell neoplasm or, if present, demonstration of clonality of myeloid cells by cytogenetic or molecular studies.
 |}
@@ Line 60: / Line 49: @@
 {{WH}}
 {{WS}}
+]
+[[Category:Up-To-Date]]
+[[Category:Medicine]]
+[[Category:Oncology]]
+[[Category:Hematology]]
+[[Category:Immunology]]