Chronic neutrophilic leukemia laboratory findings: Difference between revisions
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{{Chronic neutrophilic leukemia}} | {{Chronic neutrophilic leukemia}} | ||
{{CMG}}; {{AE}}{{Homa}} | {{CMG}}; {{AE}} {{Homa}}; {{GRR}} {{Nat}} | ||
==Overview== | ==Overview== | ||
A chronic elevated [[concentration]] of [[blood]] mature [[Neutrophil|neutrophils]] is [[diagnostic]] for chronic neutrophilic leukemia (CNL). There are other [[blood]], [[bone marrow]] and [[genetic]] [[test]]<nowiki/>s which help the [[diagnosis]] of CNL | A chronic elevated [[concentration]] of [[blood]] mature [[Neutrophil|neutrophils]] is [[diagnostic]] for chronic neutrophilic leukemia (CNL). There are other [[blood]], [[bone marrow]] and [[genetic]] [[test]]<nowiki/>s which help the [[diagnosis]] of CNL. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
| Line 21: | Line 22: | ||
| month = January | | month = January | ||
| pmid = 11841395 | | pmid = 11841395 | ||
}}</ref><ref name="PiliotisKutas2009">{{cite journal|last1=Piliotis|first1=E.|last2=Kutas|first2=G.|last3=Lipton|first3=J.H.|title=Allogeneic Bone Marrow Transplantation in the Management of Chronic Neutrophilic Leukemia|journal=Leukemia & Lymphoma|volume=43|issue=10|year=2009|pages=2051–2054|issn=1042-8194|doi=10.1080/1042819021000016087 | }}</ref><ref name="PiliotisKutas2009">{{cite journal|last1=Piliotis|first1=E.|last2=Kutas|first2=G.|last3=Lipton|first3=J.H.|title=Allogeneic Bone Marrow Transplantation in the Management of Chronic Neutrophilic Leukemia|journal=Leukemia & Lymphoma|volume=43|issue=10|year=2009|pages=2051–2054|issn=1042-8194|doi=10.1080/1042819021000016087}}</ref><ref name="DonatoCroci1986">{{cite journal|last1=Donato|first1=Carlo Di|last2=Croci|first2=Gianfranco|last3=Lazzari|first3=Stefano|last4=Scarduelli|first4=Laura|last5=Vignoli|first5=Roberto|last6=Buia|first6=Marco|last7=Tramaloni|first7=Casimiro|last8=Maccari|first8=Sergio|last9=Plancher|first9=Angelo Cesare|title=Chronic Neutrophilic Leukemia: Description of a New Case with Karyotypic Abnormalities|journal=American Journal of Clinical Pathology|volume=85|issue=3|year=1986|pages=369–371|issn=1943-7722|doi=10.1093/ajcp/85.3.369}}</ref><ref>{{Cite journal | ||
| author = [[Michelle A. Elliott]] | | author = [[Michelle A. Elliott]] | ||
| title = Chronic neutrophilic leukemia: a contemporary review | | title = Chronic neutrophilic leukemia: a contemporary review | ||
| Line 41: | Line 42: | ||
| month = December | | month = December | ||
| pmid = 16330446 | | pmid = 16330446 | ||
}}</ref> | }}</ref><ref name="PardananiLasho2013">{{cite journal|last1=Pardanani|first1=A|last2=Lasho|first2=T L|last3=Laborde|first3=R R|last4=Elliott|first4=M|last5=Hanson|first5=C A|last6=Knudson|first6=R A|last7=Ketterling|first7=R P|last8=Maxson|first8=J E|last9=Tyner|first9=J W|last10=Tefferi|first10=A|title=CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia|journal=Leukemia|volume=27|issue=9|year=2013|pages=1870–1873|issn=0887-6924|doi=10.1038/leu.2013.122}}</ref><ref name="MaxsonGotlib2013">{{cite journal|last1=Maxson|first1=Julia E.|last2=Gotlib|first2=Jason|last3=Pollyea|first3=Daniel A.|last4=Fleischman|first4=Angela G.|last5=Agarwal|first5=Anupriya|last6=Eide|first6=Christopher A.|last7=Bottomly|first7=Daniel|last8=Wilmot|first8=Beth|last9=McWeeney|first9=Shannon K.|last10=Tognon|first10=Cristina E.|last11=Pond|first11=J. Blake|last12=Collins|first12=Robert H.|last13=Goueli|first13=Basem|last14=Oh|first14=Stephen T.|last15=Deininger|first15=Michael W.|last16=Chang|first16=Bill H.|last17=Loriaux|first17=Marc M.|last18=Druker|first18=Brian J.|last19=Tyner|first19=Jeffrey W.|title=Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML|journal=New England Journal of Medicine|volume=368|issue=19|year=2013|pages=1781–1790|issn=0028-4793|doi=10.1056/NEJMoa1214514}}</ref><ref name="GotlibMaxson2013">{{cite journal|last1=Gotlib|first1=J.|last2=Maxson|first2=J. E.|last3=George|first3=T. I.|last4=Tyner|first4=J. W.|title=The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment|journal=Blood|volume=122|issue=10|year=2013|pages=1707–1711|issn=0006-4971|doi=10.1182/blood-2013-05-500959}}</ref><ref name="MeggendorferHaferlach2014">{{cite journal|last1=Meggendorfer|first1=M.|last2=Haferlach|first2=T.|last3=Alpermann|first3=T.|last4=Jeromin|first4=S.|last5=Haferlach|first5=C.|last6=Kern|first6=W.|last7=Schnittger|first7=S.|title=Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia|journal=Haematologica|volume=99|issue=12|year=2014|pages=e244–e246|issn=0390-6078|doi=10.3324/haematol.2014.113159}}</ref><ref name="CuiLi2014">{{cite journal|last1=Cui|first1=Yajuan|last2=Li|first2=Bing|last3=Gale|first3=Robert Peter|last4=Jiang|first4=Qian|last5=Xu|first5=Zefeng|last6=Qin|first6=Tiejun|last7=Zhang|first7=Peihong|last8=Zhang|first8=Yue|last9=Xiao|first9=Zhijian|title=CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia|journal=Journal of Hematology & Oncology|volume=7|issue=1|year=2014|issn=1756-8722|doi=10.1186/s13045-014-0077-1}}</ref><ref name="DaoTyner2015">{{cite journal|last1=Dao|first1=K.-H. T.|last2=Tyner|first2=J. W.|title=What's different about atypical CML and chronic neutrophilic leukemia?|journal=Hematology|volume=2015|issue=1|year=2015|pages=264–271|issn=1520-4391|doi=10.1182/asheducation-2015.1.264}}</ref> | ||
===== '''Blood tests:''' ===== | ===== '''Blood tests:''' ===== | ||
* [[Peripheral blood]] [[White blood cells]] (WBC) ≥25 ×10<sup>9</sup>/L | * [[Peripheral blood]] [[White blood cells]] (WBC) ≥25 ×10<sup>9</sup>/L | ||
| Line 52: | Line 50: | ||
* Mild [[anemia]] | * Mild [[anemia]] | ||
* [[Thrombocytopenia]] | * [[Thrombocytopenia]] | ||
==== Blood chemistry tests: ==== | ==== Blood chemistry tests: ==== | ||
| Line 84: | Line 75: | ||
**[[Trisomy 9]] | **[[Trisomy 9]] | ||
**Detection of JAK2V617F | **Detection of JAK2V617F | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Up-To-Date]] | [[Category:Up-To-Date]] | ||
[[Category:Medicine]] | [[Category:Medicine]] | ||
| Line 96: | Line 86: | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Immunology]] | [[Category:Immunology]] | ||
Latest revision as of 20:57, 29 July 2020
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Chronic neutrophilic leukemia Microchapters |
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Differentiating Chronic neutrophilic leukemia from other Diseases |
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Risk calculators and risk factors for Chronic neutrophilic leukemia laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
A chronic elevated concentration of blood mature neutrophils is diagnostic for chronic neutrophilic leukemia (CNL). There are other blood, bone marrow and genetic tests which help the diagnosis of CNL.
Laboratory Findings
A chronic elevated concentration of blood mature neutrophils is diagnostic for CNL.[1]
Some patients with CNL may have:[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]
Blood tests:
- Peripheral blood White blood cells (WBC) ≥25 ×109/L
- Segmented neutrophils plus band forms ≥80% of WBC
- Myeloblasts rarely observed
- Monocyte count <1 ×109/L
- Mild anemia
- Thrombocytopenia
Blood chemistry tests:
- Elevation of lactate dehydrogenase (LDH).
Blood vitamin analysis:
- Elevation of vitamin B12
Genetic tests:
- Cytogenetic abnormalities which may seen:
- Trisomy 8
- Trisomy 21
- Deletion 11q
- Deletion 20q6
- Deletion Y
- Trisomy 7
- Trisomy 9
- Detection of JAK2V617F
References
- ↑ 1.0 1.1 Elliott, M A; Hanson, C A; Dewald, G W; Smoley, S A; Lasho, T L; Tefferi, A (2004). "WHO-defined chronic neutrophilic leukemia: a long-term analysis of 12 cases and a critical review of the literature". Leukemia. 19 (2): 313–317. doi:10.1038/sj.leu.2403562. ISSN 0887-6924.
- ↑ Hasle, Henrik; Olesen, Gitte; Kerndrup, GITTE; Philip, Preben; Jacobsen, Niels (1996). "Chronic neutrophil leukaemia in adolescence and young adulthood". British Journal of Haematology. 94 (4): 628–630. doi:10.1046/j.1365-2141.1996.7082329.x. ISSN 0007-1048.
- ↑ Elliott, Michelle A. (2006). "Chronic neutrophilic leukemia and chronic myelomonocytic leukemia: WHO defined". Best Practice & Research Clinical Haematology. 19 (3): 571–593. doi:10.1016/j.beha.2005.07.012. ISSN 1521-6926.
- ↑ Arber, D. A.; Orazi, A.; Hasserjian, R.; Thiele, J.; Borowitz, M. J.; Le Beau, M. M.; Bloomfield, C. D.; Cazzola, M.; Vardiman, J. W. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–2405. doi:10.1182/blood-2016-03-643544. ISSN 0006-4971.
- ↑ Elliott, Michelle A.; Pardanani, Animesh; Hanson, Curtis A.; Lasho, Terra L.; Finke, Christy M.; Belachew, Alem A.; Tefferi, Ayalew (2015). "ASXL1mutations are frequent and prognostically detrimental inCSF3R-mutated chronic neutrophilic leukemia". American Journal of Hematology. 90 (7): 653–656. doi:10.1002/ajh.24031. ISSN 0361-8609.
- ↑ John T. Reilly (2002). "Chronic neutrophilic leukaemia: a distinct clinical entity?". British journal of haematology. 116 (1): 10–18. PMID 11841395. Unknown parameter
|month=ignored (help) - ↑ Piliotis, E.; Kutas, G.; Lipton, J.H. (2009). "Allogeneic Bone Marrow Transplantation in the Management of Chronic Neutrophilic Leukemia". Leukemia & Lymphoma. 43 (10): 2051–2054. doi:10.1080/1042819021000016087. ISSN 1042-8194.
- ↑ Donato, Carlo Di; Croci, Gianfranco; Lazzari, Stefano; Scarduelli, Laura; Vignoli, Roberto; Buia, Marco; Tramaloni, Casimiro; Maccari, Sergio; Plancher, Angelo Cesare (1986). "Chronic Neutrophilic Leukemia: Description of a New Case with Karyotypic Abnormalities". American Journal of Clinical Pathology. 85 (3): 369–371. doi:10.1093/ajcp/85.3.369. ISSN 1943-7722.
- ↑ Michelle A. Elliott (2004). "Chronic neutrophilic leukemia: a contemporary review". Current hematology reports. 3 (3): 210–217. PMID 15087070. Unknown parameter
|month=ignored (help) - ↑ Donald P. Mc Lornan, Melanie J. Percy, Amy V. Jones, Nicholas C. P. Cross & Mary Frances Mc Mullin (2005). "Chronic neutrophilic leukemia with an associated V617F JAK2 tyrosine kinase mutation". Haematologica. 90 (12): 1696–1697. PMID 16330446. Unknown parameter
|month=ignored (help) - ↑ Pardanani, A; Lasho, T L; Laborde, R R; Elliott, M; Hanson, C A; Knudson, R A; Ketterling, R P; Maxson, J E; Tyner, J W; Tefferi, A (2013). "CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia". Leukemia. 27 (9): 1870–1873. doi:10.1038/leu.2013.122. ISSN 0887-6924.
- ↑ Maxson, Julia E.; Gotlib, Jason; Pollyea, Daniel A.; Fleischman, Angela G.; Agarwal, Anupriya; Eide, Christopher A.; Bottomly, Daniel; Wilmot, Beth; McWeeney, Shannon K.; Tognon, Cristina E.; Pond, J. Blake; Collins, Robert H.; Goueli, Basem; Oh, Stephen T.; Deininger, Michael W.; Chang, Bill H.; Loriaux, Marc M.; Druker, Brian J.; Tyner, Jeffrey W. (2013). "Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML". New England Journal of Medicine. 368 (19): 1781–1790. doi:10.1056/NEJMoa1214514. ISSN 0028-4793.
- ↑ Gotlib, J.; Maxson, J. E.; George, T. I.; Tyner, J. W. (2013). "The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment". Blood. 122 (10): 1707–1711. doi:10.1182/blood-2013-05-500959. ISSN 0006-4971.
- ↑ Meggendorfer, M.; Haferlach, T.; Alpermann, T.; Jeromin, S.; Haferlach, C.; Kern, W.; Schnittger, S. (2014). "Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia". Haematologica. 99 (12): e244–e246. doi:10.3324/haematol.2014.113159. ISSN 0390-6078.
- ↑ Cui, Yajuan; Li, Bing; Gale, Robert Peter; Jiang, Qian; Xu, Zefeng; Qin, Tiejun; Zhang, Peihong; Zhang, Yue; Xiao, Zhijian (2014). "CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia". Journal of Hematology & Oncology. 7 (1). doi:10.1186/s13045-014-0077-1. ISSN 1756-8722.
- ↑ Dao, K.-H. T.; Tyner, J. W. (2015). "What's different about atypical CML and chronic neutrophilic leukemia?". Hematology. 2015 (1): 264–271. doi:10.1182/asheducation-2015.1.264. ISSN 1520-4391.