Complex regional pain syndrome pathophysiology: Difference between revisions
No edit summary |
m Bot: Removing from Primary care |
||
| (4 intermediate revisions by 3 users not shown) | |||
| Line 3: | Line 3: | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
Recent research has suggested that [[oxidative]] damage (e.g. by [[free radicals]]) may play a role in the pathophysiology of complex regional pain syndrome. The [[sympathetic nervous system]] may also play an important role in the pain aspect of the condition. Another theory is that CRPS is caused by a triggering of the [[immune response]]. | |||
==Pathophysiology== | ==Pathophysiology== | ||
The [[pathophysiology]] of CRPS remains unclear. However, recent research has suggested that [[oxidative]] damage (e.g. by [[free radicals]]) associated with one of the precipitating factors described earlier may play a role.<ref name="vitaminc">{{cite journal | author=Zollinger PE, Tuinebreijer WE, Breederveld RS, Kreis RW | title=Can Vitamin C Prevent Complex Regional Pain Syndrome in Patients with Wrist Fractures? A Randomized, Controlled, Multicenter Dose-Response Study | journal=J Bone Joint Surg Am | year=2007 | pages=1424-1431 | volume=89 | issue=7 | id=PMID 17606778}}</ref> | The [[pathophysiology]] of CRPS remains unclear. However, recent research has suggested that [[oxidative]] damage (e.g. by [[free radicals]]) associated with one of the precipitating factors described earlier may play a role.<ref name="vitaminc">{{cite journal | author=Zollinger PE, Tuinebreijer WE, Breederveld RS, Kreis RW | title=Can Vitamin C Prevent Complex Regional Pain Syndrome in Patients with Wrist Fractures? A Randomized, Controlled, Multicenter Dose-Response Study | journal=J Bone Joint Surg Am | year=2007 | pages=1424-1431 | volume=89 | issue=7 | id=PMID 17606778}}</ref> | ||
| Line 18: | Line 20: | ||
* Nerves | * Nerves | ||
* Skin | * Skin | ||
===Susceptibility=== | ===Susceptibility=== | ||
| Line 38: | Line 33: | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Orthopedics]] | [[Category:Orthopedics]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Disease]] | |||
Latest revision as of 21:02, 29 July 2020
|
Complex regional pain syndrome Microchapters |
|
Differentiating Complex Regional Pain Syndrome from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Complex regional pain syndrome pathophysiology On the Web |
|
American Roentgen Ray Society Images of Complex regional pain syndrome pathophysiology |
|
Directions to Hospitals Treating Complex regional pain syndrome |
|
Risk calculators and risk factors for Complex regional pain syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Recent research has suggested that oxidative damage (e.g. by free radicals) may play a role in the pathophysiology of complex regional pain syndrome. The sympathetic nervous system may also play an important role in the pain aspect of the condition. Another theory is that CRPS is caused by a triggering of the immune response.
Pathophysiology
The pathophysiology of CRPS remains unclear. However, recent research has suggested that oxidative damage (e.g. by free radicals) associated with one of the precipitating factors described earlier may play a role.[1]
Doctors aren't sure what causes CRPS. In some cases, the sympathetic nervous system plays an important role in the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the inflammatory symptoms of redness, warmth, and swelling in the affected area.
CRPS is thought to result from damage to the nervous system, including the nerves that control the blood vessels and sweat glands.
The damaged nerves are no longer able to properly control blood flow, feeling (sensation), and temperature to the affected area. This leads to medical problems in the:
- Blood vessels
- Bones
- Muscles
- Nerves
- Skin
Susceptibility
CRPS can strike at any age, but is more common between the ages of 40 and 60. It affects both men and women, but is more frequently seen in women. The number of reported CRPS cases among adolescents and young adults is increasing.
Investigators estimate that two to five percent of those with peripheral nerve injury and 12 to 21 percent of those with hemiplegia (paralysis of one side of the body) will suffer from CRPS.
Research has demonstrated that the administration of Vitamin C after an injury may decrease one's susceptibility to developing CRPS.[1]