Cystitis future or investigational therapies: Difference between revisions

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{{Cystitis}}
{{Cystitis}}
 
{{CMG}} {{AE}} {{USAMA}}
==Overview==
==Overview==
Cystitis can be hard to treat and recurrence can be an important concern. The complications of cystitis and some carcinomas associated with it sometimes require an aggressive approach. new modalities help improve the existing treatment options and limit further complications.Pulsed radio frequency treatment is one such advancement.<ref name="pmid27930554">{{cite journal| author=Kim JH, Kim E, Kim BI| title=Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 49 | pages= e5549 | pmid=27930554 | doi=10.1097/MD.0000000000005549 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27930554  }} </ref>
Cystitis can be hard to treat and recurrence can be an important concern. The complications of cystitis and some carcinomas associated with it sometimes require an aggressive approach. new modalities help improve the existing treatment options and limit further complications. Pulsed radiofrequency treatment is one such advancement.<ref name="pmid27930554">{{cite journal| author=Kim JH, Kim E, Kim BI| title=Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 49 | pages= e5549 | pmid=27930554 | doi=10.1097/MD.0000000000005549 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27930554  }} </ref>


==Future Therapies==
==Future Therapies==
*Pulsed radiofrequency (PRF) treatment of the superior hypogastric plexus may replace conventional treatment invasive and on invasive modalities. It is responsible for providing superior hypogastric plexus with nondestructive modulation, so that majority of the pain signals are transferred from the pelvic viscera.<ref name="pmid27930554">{{cite journal| author=Kim JH, Kim E, Kim BI| title=Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 49 | pages= e5549 | pmid=27930554 | doi=10.1097/MD.0000000000005549 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27930554  }} </ref>
*Pulsed radiofrequency (PRF) treatment of the superior [[hypogastric plexus]] may replace conventional treatment invasive and on invasive modalities. It is responsible for providing superior [[hypogastric plexus]] with nondestructive modulation, so that majority of the pain signals are transferred from the pelvic viscera.<ref name="pmid27930554">{{cite journal| author=Kim JH, Kim E, Kim BI| title=Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 49 | pages= e5549 | pmid=27930554 | doi=10.1097/MD.0000000000005549 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27930554  }} </ref>
 
*Various approaches are being tried to prevent the developing resistance to certain medications. These include:<ref name="pmid16413668">{{cite journal| author=Wagenlehner FM, Naber KG| title=Treatment of bacterial urinary tract infections: presence and future. | journal=Eur Urol | year= 2006 | volume= 49 | issue= 2 | pages= 235-44 | pmid=16413668 | doi=10.1016/j.eururo.2005.12.017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16413668 }} </ref>
*Hyperbaric Oxygen is used to treat hemorrhagic cystitis associated with exposure to radiation.<ref name="pmid27906922">{{cite journal| author=Chong V, Rice M| title=The effectiveness of hyperbaric oxygen therapy (HBOT) in radiation-induced haemorrhagic cystitis. | journal=N Z Med J | year= 2016 | volume= 129 | issue= 1446 | pages= 79-83 | pmid=27906922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27906922  }} </ref> Hyperbaric Oxygen is also helpful in treating emphysematous cystitis as presence of gas in the bladder wall interferes with the tissue oxygenation and proper oxygenation may help to curtail the associated damage. <ref name="pmid26331400">{{cite journal| author=Garde H, Useros E, Hernando A, Chávez C, Paños E, Quijano P et al.| title=[Emphysematous cystitis: Report of 2 cases with different outcomes]. | journal=Arch Esp Urol | year= 2015 | volume= 68 | issue= 7 | pages= 627-32 | pmid=26331400 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26331400 }} </ref>
**Avoid prolonged use of broad spectrum [[antibiotics]]
 
**Optimal dosing
*Discontinuation of the drug causing cystitis is the first approach. Similarly in case of a foreign body like stone etc,that is leading to cystitis, removal is performed. The associated conditions like BPH etc have to be treated to make sure that the patient does not have to face recurrence of Urinary Tract Infection.
**Preventing [[infection]]
**Developing new agents


==References==
==References==
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Latest revision as of 21:12, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Usama Talib, BSc, MD [2]

Overview

Cystitis can be hard to treat and recurrence can be an important concern. The complications of cystitis and some carcinomas associated with it sometimes require an aggressive approach. new modalities help improve the existing treatment options and limit further complications. Pulsed radiofrequency treatment is one such advancement.[1]

Future Therapies

  • Pulsed radiofrequency (PRF) treatment of the superior hypogastric plexus may replace conventional treatment invasive and on invasive modalities. It is responsible for providing superior hypogastric plexus with nondestructive modulation, so that majority of the pain signals are transferred from the pelvic viscera.[1]
  • Various approaches are being tried to prevent the developing resistance to certain medications. These include:[2]
    • Avoid prolonged use of broad spectrum antibiotics
    • Optimal dosing
    • Preventing infection
    • Developing new agents

References

  1. 1.0 1.1 Kim JH, Kim E, Kim BI (2016). "Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report". Medicine (Baltimore). 95 (49): e5549. doi:10.1097/MD.0000000000005549. PMID 27930554.
  2. Wagenlehner FM, Naber KG (2006). "Treatment of bacterial urinary tract infections: presence and future". Eur Urol. 49 (2): 235–44. doi:10.1016/j.eururo.2005.12.017. PMID 16413668.


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