De Quervain's thyroiditis medical therapy: Difference between revisions

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{{De Quervain's thyroiditis }}
{{De Quervain's thyroiditis }}
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==Overview==
==Overview==
The mainstay of therapy for [[de Quervain's thyroiditis]] is [[aspirin]] or [[Non-steroidal anti-inflammatory drug|non-steroidal anti-inflammatory]] drugs for pain control. [[Beta adrenergic-blocking agents|Beta-adrenergic blockers]] are recommended for the patients who develop [[Thyrotoxicosis|thyrotoxic symptoms]]. [[Corticosteroids]] are usually used in severely ill patients. [[Levothyroxine]] is required if the patient develops [[hypothyroidism]] following the resolution of the [[hyperthyroid]] state.


 
==Medical Therapy==
 
===De Quervain's thyroiditis===
 
The drugs used in the treatment of [[de Quervain's thyroiditis]] are:<ref name="pmid20886353">{{cite journal |vauthors=Engkakul P, Mahachoklertwattana P, Poomthavorn P |title=Eponym : de Quervain thyroiditis |journal=Eur. J. Pediatr. |volume=170 |issue=4 |pages=427–31 |year=2011 |pmid=20886353 |doi=10.1007/s00431-010-1306-4 |url=}}</ref><ref name="pmid3427792">{{cite journal |vauthors=Yamamoto M, Saito S, Sakurada T, Fukazawa H, Yoshida K, Kaise K, Kaise N, Nomura T, Itagaki Y, Yonemitsu K |title=Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis |journal=Clin. Endocrinol. (Oxf) |volume=27 |issue=3 |pages=339–44 |year=1987 |pmid=3427792 |doi= |url=}}</ref><ref name="pmid8257868">{{cite journal |vauthors=Volpé R |title=The management of subacute (DeQuervain's) thyroiditis |journal=Thyroid |volume=3 |issue=3 |pages=253–5 |year=1993 |pmid=8257868 |doi= |url=}}</ref><ref name="pmid6144501">{{cite journal |vauthors=Feely J, Peden N |title=Use of beta-adrenoceptor blocking drugs in hyperthyroidism |journal=Drugs |volume=27 |issue=5 |pages=425–46 |year=1984 |pmid=6144501 |doi= |url=}}</ref>
* '''For pain'''
**Preferred regimen (1): [[Naproxen]]: 500 to 1000 mg per day in two divided doses
**Preferred regimen (2): [[Ibuprofen]]: 1200 to 3200 mg per day in three or four divided doses
* '''For severe condition'''
**Preferred regimen (1): [[Prednisone]]: 40 mg per day orally
* '''For hypothyroidism'''
*Preferred regimen (1): [[Levothyroxine (oral)|Synthetic levothyroxine]] (L-T4): 1.6–1.8 μg/kg per day orally
* '''For thyrotoxic symptoms'''
**Preferred regimen (1): [[atenolol]]: 25-200mg per day orally
**Preferred regimen (2): [[metoprolol]]: 25-200mg per day orally


==References==
==References==
{{reflist|2}}
{{reflist|2}}
[[Category:Medicine]]
[[Category:Endocrinology]]
[[Category:Up-To-Date]]

Latest revision as of 21:14, 29 July 2020

De Quervain's thyroiditis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating De Quervain's thyroiditis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary prevention

Secondary prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The mainstay of therapy for de Quervain's thyroiditis is aspirin or non-steroidal anti-inflammatory drugs for pain control. Beta-adrenergic blockers are recommended for the patients who develop thyrotoxic symptoms. Corticosteroids are usually used in severely ill patients. Levothyroxine is required if the patient develops hypothyroidism following the resolution of the hyperthyroid state.

Medical Therapy

De Quervain's thyroiditis

The drugs used in the treatment of de Quervain's thyroiditis are:[1][2][3][4]

  • For pain
    • Preferred regimen (1): Naproxen: 500 to 1000 mg per day in two divided doses
    • Preferred regimen (2): Ibuprofen: 1200 to 3200 mg per day in three or four divided doses
  • For severe condition
    • Preferred regimen (1): Prednisone: 40 mg per day orally
  • For hypothyroidism
  • Preferred regimen (1): Synthetic levothyroxine (L-T4): 1.6–1.8 μg/kg per day orally
  • For thyrotoxic symptoms
    • Preferred regimen (1): atenolol: 25-200mg per day orally
    • Preferred regimen (2): metoprolol: 25-200mg per day orally

References

  1. Engkakul P, Mahachoklertwattana P, Poomthavorn P (2011). "Eponym : de Quervain thyroiditis". Eur. J. Pediatr. 170 (4): 427–31. doi:10.1007/s00431-010-1306-4. PMID 20886353.
  2. Yamamoto M, Saito S, Sakurada T, Fukazawa H, Yoshida K, Kaise K, Kaise N, Nomura T, Itagaki Y, Yonemitsu K (1987). "Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis". Clin. Endocrinol. (Oxf). 27 (3): 339–44. PMID 3427792.
  3. Volpé R (1993). "The management of subacute (DeQuervain's) thyroiditis". Thyroid. 3 (3): 253–5. PMID 8257868.
  4. Feely J, Peden N (1984). "Use of beta-adrenoceptor blocking drugs in hyperthyroidism". Drugs. 27 (5): 425–46. PMID 6144501.