Dermatofibroma history and symptoms: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
m (Bot: Removing from Primary care)
 
(7 intermediate revisions by 3 users not shown)
Line 5: Line 5:


==Overview==
==Overview==
Although typical dermatofibromas cause little or no discomfort, [[itching]] and tenderness can occur.
The majority of [[patients]] with dermatofibroma are [[asymptomatic]]. Dermatofibroma mostly develops as a single slow  growing [[lesion]] on an extremity. Traumatized [[lesion]] may cause [[pain]], [[bleeding]], i[[Itching|tching]], erosive changes,and [[ulceration]]. Multiple dermatofibromas is a [[rare]] variant of [[disease]] which mostly seen in [[patients]] with underlying [[systemic]] [[disorders]].
==Symptoms==
Although typical dermatofibromas cause little or no discomfort, [[itching]] and tenderness can occur.
 
==Overview==
The majority of patients with [disease name] are asymptomatic.
 
OR
 
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].


==History and Symptoms==
==History and Symptoms==
*The majority of patients with [disease name] are asymptomatic.
*The majority of [[patients]] with dermatofibroma are [[asymptomatic]]. <ref name="LeeLee2015">{{cite journal|last1=Lee|first1=MiWoo|last2=Lee|first2=WooJin|last3=Jung|first3=JoonMin|last4=Won|first4=ChongHyun|last5=Chang|first5=SungEun|last6=Choi|first6=JeeHo|last7=Moon|first7=KeeChan|title=Clinical and histological patterns of dermatofibroma without gross skin surface change: A comparative study with conventional dermatofibroma|journal=Indian Journal of Dermatology, Venereology, and Leprology|volume=81|issue=3|year=2015|pages=263|issn=0378-6323|doi=10.4103/0378-6323.154795}}</ref>
OR
*Dermatofibroma mostly develops as a single slow  growing [[lesion]] on an extremity.  
*The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
*Traumatized [[lesion]] may cause:<ref name="NaversenTrask1993">{{cite journal|last1=Naversen|first1=Douglas N.|last2=Trask|first2=David M.|last3=Watson|first3=Frank H.|last4=Burket|first4=John M.|title=Painful tumors of the skin: “LEND AN EGG”|journal=Journal of the American Academy of Dermatology|volume=28|issue=2|year=1993|pages=298–300|issn=01909622|doi=10.1016/0190-9622(93)70039-V}}</ref>
*Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. 
**[[Pain]]
Dermatofibromas typically arise slowly and most often occur as a solitary nodule on an extremity, particularly the lower leg, but any cutaneous site is possible. Dermatofibromas are usually asymptomatic, but itching and pain often are noted. They are the most common of all painful skin tumors. [1] Women who shave their legs may be bothered by the razor traumatizing the lesion in that region, causing pain, bleeding, erosive changes, and ulceration. Although cases of unusually rapid growth exist, most dermatofibromas remain static for decades or persist indefinitely. Patients may describe a hard mole or unusual scar and are often concerned about the possibility of skin cancer.
**[[Bleeding]]
 
**[[Itching]]
Several lesions may be present, but rarely are numerous (ie, ≥15) tumors found. This multiple eruptive variant occurs in less than 1% of patients, approximately 60% of whom have an underlying systemic condition, such as HIV infection or systemic lupus erythematosus. [30, 31, 32] However, dermatomyositis, [33] Graves disease, [34] Hashimoto thyroiditis, [35] myasthenia gravis, [35] Down syndrome, [36] leukemia, [37] myelodysplastic syndrome, [38] cutaneous T-cell lymphoma, [39] multiple myeloma, [39] atopic dermatitis, [40] Crohn disease, [41] and ulcerative colitis [42] have all been reported in association with the phenomenon. In addition, antiretroviral agents, [43] the biologic agent efalizumab, [44] antitumor necrosis factor-alpha agents, [45] and the tyrosine kinase inhibitor imatinib [46] have been linked to their appearance.
**Erosive changes
 
**[[Ulceration]]
Both congenital [47] and acquired [48] cases of multiple clustered dermatofibromas have been reported.
*Multiple dermatofibromas is a [[rare]] variant of [[disease]] which mostly seen in [[patients]] with underlying [[systemic]] [[disorders]]. <ref name="BhattacharjeeUmar2005">{{cite journal|last1=Bhattacharjee|first1=Pradip|last2=Umar|first2=Saleem|last3=Fatteh|first3=Shokat|title=Multiple Eruptive Dermatofibromas Occurring in a Patient with Myelodysplastic Syndrome|journal=Acta Dermato-Venereologica|volume=-1|issue=1|year=2005|pages=1–1|issn=0001-5555|doi=10.1080/00015550410024517}}</ref><ref>{{Cite journal
 
| author = [[I. Lu]], [[P. R. Cohen]] & [[M. E. Grossman]]
Dermatofibromas are slow growing lesions which can affect any part of the body but have a predilection for the extremities. Clinically these lesions are a firm, non-tender cutaneous nodule, with or without overlying skin changes (such as tan-pink to reddish-brown discoloration, depending on the age of the lesion) with a smooth surface. Dermoscopic evaluation of these lesions will most commonly exhibit a central white patch with a peripheral pigmented network. Dermatofibromas are usually less than or equal to one centimeter in diameter. Patients are usually asymptomatic but will relate a history of local trauma at the site of the lesion such as vaccination or an insect bite in approximately one out of five cases. A thorough full body skin exam is important as these lesions may be subtle and are multiple in 10% of cases. The “dimple sign” is a characteristic finding where in lateral inward digital pressure of the skin produces a central dimpling over the lesion. [8] [9]
| title = Multiple dermatofibromas in a woman with HIV infection and systemic lupus erythematosus
 
| journal = [[Journal of the American Academy of Dermatology]]
Dermatofibromas typically present as firm, often hyperpigmented, nodules 0.3 to 1 cm in diameter (picture 4A-B), but giant lesions larger than 3 cm in diameter have been described [11,12]. They occur most often in adults and are most commonly located on the lower extremities. Lesions are usually asymptomatic, but may be pruritic. On palpations, dermatofibromas are fixed to the subcutaneous tissues and characteristically dimple when pinched
| volume = 32
 
| issue = 5 Pt 2
Dermatofibromas usually develop slowly. These small, hard, raised skin growths:
| pages = 901–903
 
| year = 1995
Usually, appear on the lower legs, but may appear on the arms or trunk
| month =
May be red, pink, purplish, gray or brown and may change color over time
| doi = 10.1016/0190-9622(95)91558-3
May be as small as a BB pellet but rarely grow larger than a fingernail
| pmid = 7722054
Are often painless but may be tender, painful or itchy
|url=|first=|date=|via=}}</ref><ref>{{Cite journal
Usually, dimple inward when pinched
| author = [[P. R. Cohen]]
===History===
| title = Multiple dermatofibromas in patients with autoimmune disorders receiving immunosuppressive therapy
Patients with [disease name]] may have a positive history of:
| journal = [[International journal of dermatology]]
*[History finding 1]
| volume = 30
*[History finding 2]
| issue = 4
*[History finding 3]
| pages = 266–270
 
| year = 1991
===Common Symptoms===
| month =
Common symptoms of [disease] include:
| pmid = 2050454
*[Symptom 1]
|url=|first=|date=|via=}}</ref><ref>{{Cite journal
*[Symptom 2]
| author = [[Mayuri Tanaka]], [[Toshihiko Hoashi]], [[Naotaka Serizawa]], [[Kyochika Okabe]], [[Susumu Ichiyama]], [[Rie Shinohara]], [[Yoko Funasaka]] & [[Hidehisa Saeki]]
*[Symptom 3]
| title = Multiple unilaterally localized dermatofibromas in a patient with Down syndrome
| journal = [[The Journal of dermatology]]
| volume = 44
| issue = 9
| pages = 1074–1076
| year = 2017
| month =
| doi = 10.1111/1346-8138.13625
| pmid = 27665731
|url=|first=|date=|via=}}</ref><ref>{{Cite journal
| author = [[J. Stainforth]] & [[M. J. Goodfield]]
| title = Multiple dermatofibromata developing during pregnancy
| journal = [[Clinical and experimental dermatology]]
| volume = 19
| issue = 1
| pages = 59–60
| year = 1994
| month =
| pmid = 8313640
|url=|first=|date=|via=}}</ref><ref>{{Cite journal
| author = [[Yuichiro Tsunemi]], [[Hironobu Ihn]], [[Naoko Hattori]], [[Hidehisa Saeki]] & [[Kunihiko Tamaki]]
| title = Multiple eruptive dermatofibromas with CD34+ cells in a patient with hypertriglyceridemia
| journal = [[Dermatology (Basel, Switzerland)]]
| volume = 207
| issue = 3
| pages = 319–321
| year = 2003
| month =
| doi = 10.1159/000073098
| pmid = 14571078
}}</ref><ref>{{Cite journal
| author = [[H. B. Bargman]] & [[I. Fefferman]]
| title = Multiple dermatofibromas in a patient with myasthenia gravis treated with prednisone and cyclophosphamide
| journal = [[Journal of the American Academy of Dermatology]]
| volume = 14
| issue = 2 Pt 2
| pages = 351–352
| year = 1986
| month =
| doi = 10.1016/s0190-9622(86)70041-8
| pmid = 3950136
|url=|first=|date=|via=}}</ref><ref>{{Cite journal
| author = [[S. E. Chang]], [[J. H. Choi]], [[K. J. Sung]], [[K. C. Moon]] & [[J. K. Koh]]
| title = Multiple eruptive dermatofibromas occurring in a patient with acute myeloid leukaemia
| journal = [[The British journal of dermatology]]
| volume = 142
| issue = 5
| pages = 1062–1063
| year = 2000
| month =
| doi = 10.1046/j.1365-2133.2000.03508.x
| pmid = 10809884
|url=|first=|date=|via=}}</ref>
[[File:Dermatofibroma.jpg|200px|thumb|Contributed by creative commons|center]]
[[File:Dermoscopy of dermatofibroma.png|350px|thumb|https://openi.nlm.nih.gov/detailedresult?img=PMC3667312_IJD-58-243a-g003&query=&req=4|center]]
[[File:Multiple dermatofibromas.png|200px|thumb|https://openi.nlm.nih.gov/detailedresult?img=PMC3875973_abd-88-06-s1-0063-g05&query=&req=4|center]]


===Less Common Symptoms===
Less common symptoms of [disease name] include
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
Line 60: Line 101:
[[Category:Medicine]]
[[Category:Medicine]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Up-To-Date]]​
[[Category:Up-To-Date]]
[[Category:Primary care]]
[[Category:Dermatology]]
[[Category:Dermatology]]

Latest revision as of 21:17, 29 July 2020


Dermatofibroma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Dermatofibroma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Dermatofibroma history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Dermatofibroma history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Dermatofibroma history and symptoms

CDC on Dermatofibroma history and symptoms

Dermatofibroma history and symptoms in the news

Blogs on Dermatofibroma history and symptoms

Directions to Hospitals Treating Type page name here

Risk calculators and risk factors for Dermatofibroma history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]

Overview

The majority of patients with dermatofibroma are asymptomatic. Dermatofibroma mostly develops as a single slow growing lesion on an extremity. Traumatized lesion may cause pain, bleeding, itching, erosive changes,and ulceration. Multiple dermatofibromas is a rare variant of disease which mostly seen in patients with underlying systemic disorders.

History and Symptoms

Contributed by creative commons
https://openi.nlm.nih.gov/detailedresult?img=PMC3667312_IJD-58-243a-g003&query=&req=4
https://openi.nlm.nih.gov/detailedresult?img=PMC3875973_abd-88-06-s1-0063-g05&query=&req=4

References

  1. ↑ Lee, MiWoo; Lee, WooJin; Jung, JoonMin; Won, ChongHyun; Chang, SungEun; Choi, JeeHo; Moon, KeeChan (2015). "Clinical and histological patterns of dermatofibroma without gross skin surface change: A comparative study with conventional dermatofibroma". Indian Journal of Dermatology, Venereology, and Leprology. 81 (3): 263. doi:10.4103/0378-6323.154795. ISSN 0378-6323.
  2. ↑ Naversen, Douglas N.; Trask, David M.; Watson, Frank H.; Burket, John M. (1993). "Painful tumors of the skin: "LEND AN EGG"". Journal of the American Academy of Dermatology. 28 (2): 298–300. doi:10.1016/0190-9622(93)70039-V. ISSN 0190-9622.
  3. ↑ Bhattacharjee, Pradip; Umar, Saleem; Fatteh, Shokat (2005). "Multiple Eruptive Dermatofibromas Occurring in a Patient with Myelodysplastic Syndrome". Acta Dermato-Venereologica. -1 (1): 1–1. doi:10.1080/00015550410024517. ISSN 0001-5555.
  4. ↑ I. Lu, P. R. Cohen & M. E. Grossman (1995). "Multiple dermatofibromas in a woman with HIV infection and systemic lupus erythematosus". Journal of the American Academy of Dermatology. 32 (5 Pt 2): 901–903. doi:10.1016/0190-9622(95)91558-3. PMID 7722054.
  5. ↑ P. R. Cohen (1991). "Multiple dermatofibromas in patients with autoimmune disorders receiving immunosuppressive therapy". International journal of dermatology. 30 (4): 266–270. PMID 2050454.
  6. ↑ Mayuri Tanaka, Toshihiko Hoashi, Naotaka Serizawa, Kyochika Okabe, Susumu Ichiyama, Rie Shinohara, Yoko Funasaka & Hidehisa Saeki (2017). "Multiple unilaterally localized dermatofibromas in a patient with Down syndrome". The Journal of dermatology. 44 (9): 1074–1076. doi:10.1111/1346-8138.13625. PMID 27665731.
  7. ↑ J. Stainforth & M. J. Goodfield (1994). "Multiple dermatofibromata developing during pregnancy". Clinical and experimental dermatology. 19 (1): 59–60. PMID 8313640.
  8. ↑ Yuichiro Tsunemi, Hironobu Ihn, Naoko Hattori, Hidehisa Saeki & Kunihiko Tamaki (2003). "Multiple eruptive dermatofibromas with CD34+ cells in a patient with hypertriglyceridemia". Dermatology (Basel, Switzerland). 207 (3): 319–321. doi:10.1159/000073098. PMID 14571078.
  9. ↑ H. B. Bargman & I. Fefferman (1986). "Multiple dermatofibromas in a patient with myasthenia gravis treated with prednisone and cyclophosphamide". Journal of the American Academy of Dermatology. 14 (2 Pt 2): 351–352. doi:10.1016/s0190-9622(86)70041-8. PMID 3950136.
  10. ↑ S. E. Chang, J. H. Choi, K. J. Sung, K. C. Moon & J. K. Koh (2000). "Multiple eruptive dermatofibromas occurring in a patient with acute myeloid leukaemia". The British journal of dermatology. 142 (5): 1062–1063. doi:10.1046/j.1365-2133.2000.03508.x. PMID 10809884.
Retrieved from "https://www.wikidoc.org/index.php?title=Dermatofibroma_history_and_symptoms&oldid=1636987"