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{{Epidural abscess}}
{{Epidural abscess}}
{{CMG}}; {{AE}} {{JS}}
{{CMG}} {{AE}} {{JS}}; {{AG}}


==Overview==
==Overview==
An epidural abscess is a rare [[suppurative]] [[infection]] of the [[central nervous system]], a collection of [[pus]] localised in the [[epidural space]] lying outside the [[dura mater]], which accounts for less than 2% of focal [[CNS]] infections. <ref>{{Cite book  | last1 = Longo | first1 = Dan L. (Dan Louis) | title = Harrison's principles of internal medici | date = 2012 | publisher = McGraw-Hill | location = New York | isbn = 978-0-07-174889-6 | pages =  }}</ref> It may occur in two different places: [[intracranial space|intracranially]] or in the [[spinal canal]].  Because the initial [[symptoms]] and clinical characteristics are not always identical, and are similar to the ones in other diseases, along with the fact that they are both rare conditions, the final [[diagnosis]] might be delayed in time. This late [[diagnosis]] comes at great cost to the patient, since it is usually accompanied by a bad [[prognosis]] and severe [[complications]] with a potential fatal outcome. The [[diagnosis]] of epidural abscess should be first suspected from the clinical findings and posteriorly supported by laboratory tests and imaging studies, however it can only be confirmed after surgical drainage and proper study of the collected material. The laboratory test, despite helpful are not diagnostic and should always be used along history taking, clinical examination and imaging studies. According to the location of the collection, the [[abscess]] may have different origins, different organisms involved, [[symptoms]],  evolutions, [[complications]] and therapeutical techniques. <ref name="DannerHartman1987">{{cite journal|last1=Danner|first1=R. L.|last2=Hartman|first2=B. J.|title=Update of Spinal Epidural Abscess: 35 Cases and Review of the Literature|journal=Clinical Infectious Diseases|volume=9|issue=2|year=1987|pages=265–274|issn=1058-4838|doi=10.1093/clinids/9.2.265}}</ref><ref name="Darouiche2006">{{cite journal|last1=Darouiche|first1=Rabih O.|title=Spinal Epidural Abscess|journal=New England Journal of Medicine|volume=355|issue=19|year=2006|pages=2012–2020|issn=0028-4793|doi=10.1056/NEJMra055111}}</ref>
[[X ray]] is likely not helpful in the diagnosis of epidural abscess. [[Myelography]] may be helpful in the diagnosis of epidural abscess, however it is now considered obsolete.


==X Ray==
==Other Imaging Findings==
Despite the fact that the [[X-Ray]] is not an ideal imaging test to study the [[epidural abscess]], it is useful to evaluate possible [[skull fractures]], [[osteomyelitis]] lesions, [[discitis]] or foreign bodies lodged in the [[skull]] or [[spine]], which might be the source of the [[infection]]. <ref name="Hendaus2013">{{cite journal|last1=Hendaus|first1=Mohammed A.|title=Subdural Empyema in Children|journal=Global Journal of Health Science|volume=5|issue=6|year=2013|issn=1916-9744|doi=10.5539/gjhs.v5n6p54}}</ref> Despite the fact that epidural abscesses are not normally seen in [[X Ray]]s, a study from David R. Maslen ''et all'', showed that in 30% of the cases, the [[X Ray]] showed some kind of abnormality in these patients, often reporting degenerative changes, vertebral end-plate destruction or narrowing of the [[Intervertebral disc|disc]] space. <ref name="pmid8333809">{{cite journal| author=Maslen DR, Jones SR, Crislip MA, Bracis R, Dworkin RJ, Flemming JE| title=Spinal epidural abscess. Optimizing patient care. | journal=Arch Intern Med | year= 1993 | volume= 153 | issue= 14 | pages= 1713-21 | pmid=8333809 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8333809  }} </ref>
===X Ray===
[[X ray]] is likely not helpful in the diagnosis of epidural abscess. Findings on x ray suggestive of spinal epidural abscess include narrowing of the disk and bone [[lysis]] to indicate the presence of [[discitis]] and [[osteomyelitis]].<ref name="pmid17093252">{{cite journal |vauthors=Darouiche RO |title=Spinal epidural abscess |journal=The New England Journal of Medicine |volume=355 |issue=19 |pages=2012–20 |year=2006 |pmid=17093252 |doi=10.1056/NEJMra055111 |url=}}</ref><ref name=RadioSEA> Spinal Epidural Abscess. Radiopaedia.org (2015). http://radiopaedia.org/articles/spinal-epidural-abscess Accessed on November 20, 2015</ref> X ray is useful in evaluating possible [[skull fractures]], [[osteomyelitis]] lesions, [[discitis]], or [[foreign bodies]] lodged in the [[skull]] or [[spine]], which may be the source of the [[infection]].<ref name="Hendaus2013">{{cite journal|last1=Hendaus|first1=Mohammed A.|title=Subdural Empyema in Children|journal=Global Journal of Health Science|volume=5|issue=6|year=2013|issn=1916-9744|doi=10.5539/gjhs.v5n6p54}}</ref> In 30% of patients with epidural abscess, radiography demonstrated some abnormality, often presenting degenerative changes, [[vertebral]] end-plate destruction, or narrowing of the [[intervertebral disc]] space.<ref name="pmid8333809">{{cite journal| author=Maslen DR, Jones SR, Crislip MA, Bracis R, Dworkin RJ, Flemming JE| title=Spinal epidural abscess. Optimizing patient care. | journal=Arch Intern Med | year= 1993 | volume= 153 | issue= 14 | pages= 1713-21 | pmid=8333809 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8333809  }} </ref>


In the case of '''[[myelography]]''', despite the increased [[sensitivity]] to diagnose epidural abscess, the invasiveness of this technique and possible complications, give more relevance to the [[MRI]].<ref name="Grewal2006">{{cite journal|last1=Grewal|first1=S.|title=Epidural abscesses|journal=British Journal of Anaesthesia|volume=96|issue=3|year=2006|pages=292–302|issn=0007-0912|doi=10.1093/bja/ael006}}</ref>
[[Image:L5-S1 intervertebral narrowing.jpg|left|200px|thumb|Intervertebral narrowing at the level of L5-S1, with concomitant sclerosis of vertebral plateau<ref name=SEAXRay> Image courtesy of Dr Maxime St-Amant. [http://www.radiopaedia.org Radiopaedia] (original file [http://radiopaedia.org/cases/spondylodiscitis-l5-s1-with-epidural-abscesses "here"]). [http://radiopaedia.org/licence Creative Commons BY-SA-NC]</ref>]]
<br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>
 
===Myelography===
[[Myelography]] may be helpful in the diagnosis of epidural abscess. However, the invasiveness of this technique and possible [[complications]] give more relevance to the [[MRI]].<ref name="Grewal2006">{{cite journal|last1=Grewal|first1=S.|title=Epidural abscesses|journal=British Journal of Anaesthesia|volume=96|issue=3|year=2006|pages=292–302|issn=0007-0912|doi=10.1093/bja/ael006}}</ref>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Wikinfect]]
[[Category:Infectious disease]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Primary care]]

Latest revision as of 21:36, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]; Anthony Gallo, B.S. [3]

Overview

X ray is likely not helpful in the diagnosis of epidural abscess. Myelography may be helpful in the diagnosis of epidural abscess, however it is now considered obsolete.

Other Imaging Findings

X Ray

X ray is likely not helpful in the diagnosis of epidural abscess. Findings on x ray suggestive of spinal epidural abscess include narrowing of the disk and bone lysis to indicate the presence of discitis and osteomyelitis.[1][2] X ray is useful in evaluating possible skull fractures, osteomyelitis lesions, discitis, or foreign bodies lodged in the skull or spine, which may be the source of the infection.[3] In 30% of patients with epidural abscess, radiography demonstrated some abnormality, often presenting degenerative changes, vertebral end-plate destruction, or narrowing of the intervertebral disc space.[4]

Intervertebral narrowing at the level of L5-S1, with concomitant sclerosis of vertebral plateau[5]


























Myelography

Myelography may be helpful in the diagnosis of epidural abscess. However, the invasiveness of this technique and possible complications give more relevance to the MRI.[6]

References

  1. Darouiche RO (2006). "Spinal epidural abscess". The New England Journal of Medicine. 355 (19): 2012–20. doi:10.1056/NEJMra055111. PMID 17093252.
  2. Spinal Epidural Abscess. Radiopaedia.org (2015). http://radiopaedia.org/articles/spinal-epidural-abscess Accessed on November 20, 2015
  3. Hendaus, Mohammed A. (2013). "Subdural Empyema in Children". Global Journal of Health Science. 5 (6). doi:10.5539/gjhs.v5n6p54. ISSN 1916-9744.
  4. Maslen DR, Jones SR, Crislip MA, Bracis R, Dworkin RJ, Flemming JE (1993). "Spinal epidural abscess. Optimizing patient care". Arch Intern Med. 153 (14): 1713–21. PMID 8333809.
  5. Image courtesy of Dr Maxime St-Amant. Radiopaedia (original file "here"). Creative Commons BY-SA-NC
  6. Grewal, S. (2006). "Epidural abscesses". British Journal of Anaesthesia. 96 (3): 292–302. doi:10.1093/bja/ael006. ISSN 0007-0912.