Fibroadenoma classification: Difference between revisions

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Latest revision as of 21:45, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2] Haytham Allaham, M.D. [3]

Overview

Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, giant fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.

Classification

Fibroadenoma may be classified according to microscopic histopathological analysis into five subtypes, which include:^[1]

Juvenile fibroadenoma
Complex fibroadenoma
Giant fibroadenoma
Myxoid fibroadenoma
Cellular fibroadenoma

The table below differentiates between the main subtypes of fibrodenoma according to microscopic histopathological analysis:^[1]^[2]^[3]


Fibroadenoma Subtype	Description

Juvenile fibroadenoma	Commonly found in ages 10 to 18 years. Stromal and epithelial hyperplasia Tapering, thin micropapillae (gynecomastoid hyperplasia) Mitoses is absent Occurs mostly in African Americans Rapid growth Associated with skin ulcerations and prominent veins Referred to as a giant fibroadenoma when it is >5cm, >500g, or replaces more than 80% of the breast
Complex fibroadenoma	Excessive proliferation of epithelial cells Apocrine metaplasia Cysts > 3 mm Calcification Sclerosing adenosis
Giant fibroadenoma	>5cm in diameter High stromal cellularity Rapid growth Usually seen in pregnant or lactating women
Myxoid fibroadenoma	Myxoid stroma
Cellular fibroadenoma	Relatively high cellular component Increased mitotic rate Absence of calcification and sclerosing adenosis Sometimes referred to as juvenile fibroadenoma

References

↑ ^1.0 ^1.1 Cerrato F, Labow BI (2013). "Diagnosis and management of fibroadenomas in the adolescent breast". Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.
↑ Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A; et al. (2017). "A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review". Int J Surg Case Rep. 41: 427–430. doi:10.1016/j.ijscr.2017.11.026. PMC 5702868. PMID 29546008.
↑ Greenberg R, Skornick Y, Kaplan O (1998). "Management of breast fibroadenomas". J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.

Template:WH Template:WS

[pmid24872735-1] 1.0 ^1.1 Cerrato F, Labow BI (2013). "Diagnosis and management of fibroadenomas in the adolescent breast". Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.

[pmid29546008-2] Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A; et al. (2017). "A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review". Int J Surg Case Rep. 41: 427–430. doi:10.1016/j.ijscr.2017.11.026. PMC 5702868. PMID 29546008.

[pmid9754521-3] Greenberg R, Skornick Y, Kaplan O (1998). "Management of breast fibroadenomas". J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.

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[2]

[3]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Fibroadenoma}}
-{{CMG}} {{AE}} {{HL}}
+{{CMG}} {{AE}} {{IO}} {{HL}}
 ==Overview==
-Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.<ref name="patho">Fibroadenoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Fibroadenoma Accessed on January, 29 2016</ref>
+Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, giant fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.
 ==Classification==
-* Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include:<ref name="patho">Fibroadenoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Fibroadenoma Accessed on January, 29 2016</ref>
+* Fibroadenoma may be classified according to microscopic histopathological analysis into five subtypes, which include:<ref name="pmid24872735">{{cite journal| author=Cerrato F, Labow BI| title=Diagnosis and management of fibroadenomas in the adolescent breast. | journal=Semin Plast Surg | year= 2013 | volume= 27 | issue= 1 | pages= 23-5 | pmid=24872735 | doi=10.1055/s-0033-1343992 | pmc=3706050 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24872735  }} </ref>
 :* Juvenile fibroadenoma
 :* Complex fibroadenoma
+:* Giant fibroadenoma
 :* Myxoid fibroadenoma
 :* Cellular fibroadenoma
+* The table below differentiates between the main subtypes of fibrodenoma according to microscopic histopathological analysis:<ref name="pmid24872735">{{cite journal| author=Cerrato F, Labow BI| title=Diagnosis and management of fibroadenomas in the adolescent breast. | journal=Semin Plast Surg | year= 2013 | volume= 27 | issue= 1 | pages= 23-5 | pmid=24872735 | doi=10.1055/s-0033-1343992 | pmc=3706050 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24872735  }} </ref><ref name="pmid29546008">{{cite journal| author=Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A et al.| title=A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review. | journal=Int J Surg Case Rep | year= 2017 | volume= 41 | issue=  | pages= 427-430 | pmid=29546008 | doi=10.1016/j.ijscr.2017.11.026 | pmc=5702868 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29546008  }} </ref><ref name="pmid9754521">{{cite journal| author=Greenberg R, Skornick Y, Kaplan O| title=Management of breast fibroadenomas. | journal=J Gen Intern Med | year= 1998 | volume= 13 | issue= 9 | pages= 640-5 | pmid=9754521 | doi= | pmc=1497021 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9754521  }} </ref>
+{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
+|valign=top|
+|+
+! style="background: #4479BA; width: 250px; color: #FFFFFF;"|'''Fibroadenoma Subtype'''
+! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Description'''
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Juvenile fibroadenoma '''|| style="padding: 5px 5px; background: #F5F5F5;" |
+:* Commonly found in ages 10 to 18 years.
+:* Stromal and epithelial hyperplasia
+:* Tapering, thin micropapillae (gynecomastoid hyperplasia)
+:* Mitoses is absent
+:* Occurs mostly in African Americans
+:* Rapid growth
+:* Associated with skin ulcerations and prominent veins
+:* Referred to as a giant fibroadenoma when it is >5cm, >500g, or replaces more than 80% of the breast
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Complex fibroadenoma '''|| style="padding: 5px 5px; background: #F5F5F5;"|
+:* Excessive proliferation of epithelial cells
+:* Apocrine metaplasia
+:* Cysts > 3 mm
+:* Calcification
+:* Sclerosing adenosis
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Giant fibroadenoma ''' || style="padding: 5px 5px; background: #F5F5F5;"|
+:* >5cm in diameter
+:* High stromal cellularity
+:* Rapid growth
+:* Usually seen in pregnant or lactating women
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Myxoid fibroadenoma'''|| style="padding: 5px 5px; background: #F5F5F5;"|
+:* Myxoid stroma
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Cellular fibroadenoma '''|| style="padding: 5px 5px; background: #F5F5F5;" |
+:* Relatively high cellular component
+:* Increased mitotic rate
+:* Absence of calcification and sclerosing adenosis
+:* Sometimes referred to as juvenile fibroadenoma
+|}
 ==References==
 {{reflist|1}}
 {{Soft tissue tumors and sarcomas}}
-[[Category:Breast]]
-[[Category:Primary care]]
 {{WH}}
 {{WS}}
- [[Category:Up-To-Date]]
+[[Category:Breast]]
+[[Category:Up-To-Date]]
 [[Category:Oncology]]
 [[Category:Medicine]]

v t e Soft tissue tumors and sarcomas (ICD-O 8800-9349)
Not otherwise specified (8800-8809)	Soft tissue sarcoma - Desmoplastic small round cell tumor
Fibromatous (8810-8839)	Fibroma/fibrosarcoma - Malignant fibrous histiocytoma - Dermatofibroma/dermatofibrosarcoma - Dermatofibrosarcoma protuberans
Myxomatous (8840-8849)	Myxoma - Ossifying fibromyxoid tumour
Lipomatous (8850-8889)	Lipoma/liposarcoma (Angiomyolipoma)
Myomatous (8890-8929)	Leiomyoma/leiomyosarcoma - Myoma - Rhabdomyoma/rhabdomyosarcoma - Sarcoma botryoides
Complex Mixed And Stromal (8930-8999)	Adenomyoma - Pleomorphic adenoma - Mixed Mullerian tumor - Mesoblastic nephroma - Wilms' tumor - Rhabdoid tumour - Clear cell sarcoma of the kidney - Hepatoblastoma - Carcinosarcoma
Fibroepithelial (9000-9039)	Brenner tumour - Fibroadenoma - Phyllodes tumor
Synovial-like (9040-9049)	Synovial sarcoma - Clear cell sarcoma, NOS
Mesothelial (9050-9059)	Mesothelioma - Adenomatoid tumor
Germ cell tumors (9060-9119)	germinomatous germ cell tumors: Dysgerminoma - Germinoma - Seminoma nongerminomatous germ cell tumors: Embryonal carcinoma - Endodermal sinus tumor / Yolk sac tumor - Teratoma/Fetus in fetu / Dermoid cyst/Struma ovarii - Gestational trophoblastic disease (Hydatidiform mole) - Choriocarcinoma - Polyembryoma - Gonadoblastoma
Vascular (9120-9179)	blood vessels: Hemangioma/hemangiosarcoma - Angioma/angiosarcoma - Blue rubber bleb nevus syndrome - Hemangioendothelioma - Kaposi's sarcoma - Hemangiopericytoma lymphatic vessels: Lymphangioma/lymphangiosarcoma - Lymphangioleiomyomatosis
Osseous and chondromatous (9180-9349)	Osteoma/osteosarcoma - Osteochondroma - Chondroma/enchondroma/chondrosarcoma - Chondroblastoma - Giant cell tumor of bone - Ewing's sarcoma - Chordoma teeth/odontogenic: (Cementoblastoma, Cementoma, Odontoma, Adenomatoid odontogenic tumor, Ameloblastoma) Adamantinoma

Fibroadenoma classification: Difference between revisions

Latest revision as of 21:45, 29 July 2020

Overview

Classification

References

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