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| {{CMG}}; {{AE}} {{Sahar}} | | {{CMG}}; {{AE}} {{Sahar}} |
| ==Overview== | | ==Overview== |
| Gonadoblastoma mainly develops in the context of [[gonadal dysgenesis]]. common causes of gonadoblastoma are:[[Turner syndrome]], XY [[XX gonadal dysgenesis|gonadal dysgenesis]], [[Frasier syndrome]], [[WAGR syndrome]], [[Swyer syndrome]], and 9p partial [[monosomy]].
| | There are no established [[causes]] for gonadoblastoma. However, there are certain [[risk factors]] that predispose to increased [[risk]] of gonadoblastoma. |
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| ==Causes== | | ==Causes== |
| ===Life-threatening Causes===
| | There are no established [[causes]] for gonadoblastoma. However, there are certain [[risk factors]] that predispose to increased [[risk]] of gonadoblastoma. For more information on [[risk factors]], [[Gonadoblastoma risk factors|click here]]. |
| *There are no life-threatening causes of gonadoblastoma, however [[complications]] resulting from coexisting [[dysgerminoma]] is possible.
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| ===Common Causes===
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| Common causes of gonadoblastoma may include:<ref name="MilewiczMrozińska2016">{{cite journal|last1=Milewicz|first1=Tomasz|last2=Mrozińska|first2=Sandra|last3=Szczepański|first3=Wojciech|last4=Białas|first4=Magdalena|last5=Kiałka|first5=Marta|last6=Doroszewska|first6=Katarzyna|last7=Kabzińska-Turek|first7=Monika|last8=Wojtyś|first8=Andrzej|last9=Ludwin|first9=Artur|last10=Chmura|first10=Łukasz|title=Dysgerminoma and gonadoblastoma in the course of Swyer syndrome|journal=Polish Journal of Pathology|volume=4|year=2016|pages=411–414|issn=1233-9687|doi=10.5114/pjp.2016.65876}}</ref><ref name="QuinonezPark2013">{{cite journal|last1=Quinonez|first1=Shane C.|last2=Park|first2=John M.|last3=Rabah|first3=Raja|last4=Owens|first4=Kailey M.|last5=Yashar|first5=Beverly M.|last6=Glover|first6=Thomas W.|last7=Keegan|first7=Catherine E.|title=9p partial monosomy and disorders of sex development: Review and postulation of a pathogenetic mechanism|journal=American Journal of Medical Genetics Part A|volume=161|issue=8|year=2013|pages=1882–1896|issn=15524825|doi=10.1002/ajmg.a.36018}}</ref><ref name="urlYen & Jaffes Reproductive Endocrinology | ScienceDirect">{{cite web |url=https://www.sciencedirect.com/book/9781455727582/yen-and-jaffes-reproductive-endocrinology |title=Yen & Jaffe's Reproductive Endocrinology | ScienceDirect |format= |work= |accessdate=}}</ref><ref name="PatelPappas2013">{{cite journal|last1=Patel|first1=Payal R.|last2=Pappas|first2=John|last3=Arva|first3=Nicoleta C.|last4=Franklin|first4=Bonita|last5=Brar|first5=Preneet Cheema|title=Early presentation of bilateral gonadoblastomas in a Denys-Drash syndrome patient: a cautionary tale for prophylactic gonadectomy|journal=Journal of Pediatric Endocrinology and Metabolism|volume=26|issue=9-10|year=2013|issn=2191-0251|doi=10.1515/jpem-2012-0409}}</ref>
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| *XY [[gonadal dysgenesis]]
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| *[[Frasier syndrome]]
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| *[[WAGR syndrome]]
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| *[[Swyer syndrome]]
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| *9p partial [[monosomy]]
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| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
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| {{WH}}
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| {{WS}}
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| [[Category:Medicine]] | | [[Category:Medicine]] |
| [[Category:Primary care]]
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| [[Category:Oncology]] | | [[Category:Oncology]] |
| [[Category:Gynecology]] | | [[Category:Gynecology]] |
| [[Category:Up-To-Date]] | | [[Category:Up-To-Date]] |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
There are no established causes for gonadoblastoma. However, there are certain risk factors that predispose to increased risk of gonadoblastoma.
Causes
There are no established causes for gonadoblastoma. However, there are certain risk factors that predispose to increased risk of gonadoblastoma. For more information on risk factors, click here.
References