Gonadoblastoma historical perspective: Difference between revisions
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==Overview== | ==Overview== | ||
Gonadoblastoma was first discovered by Dr. Scully in 1953. The association between GBY gene (GonadoBlastoma on the Y chromosome) and gonadoblastoma was made in 1986. In 1995, Tsuchiya found that the GBY gene located near the [[centromere]] of [[Y chromosome]] and contains multiple [[gene]]<nowiki/>s including Testis-specific protein Y-encoded (TSPY) gene. | |||
== | ==Historical Perspective== | ||
=== | * Gonadoblastoma was first discovered by Dr. Scully, an American [[pathologist]], in 1953 studying the [[pathology]] of a series of [[tumors]] suspected of being [[Dysgerminoma|dysgerminomas]].<ref name="Scully1953">{{cite journal|last1=Scully|first1=Robert E.|title=Gonadoblastoma. A gonadal tumor related to the dysgerminoma (Seminoma) and capable of sex-hormone production|journal=Cancer|volume=6|issue=3|year=1953|pages=455–463|issn=0008-543X|doi=10.1002/1097-0142(195305)6:3<455::AID-CNCR2820060303>3.0.CO;2-U}}</ref><ref name="pmid4193741">{{cite journal| author=Scully RE| title=Gonadoblastoma. A review of 74 cases. | journal=Cancer | year= 1970 | volume= 25 | issue= 6 | pages= 1340-56 | pmid=4193741 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4193741 }}</ref><ref name="pmid3503713">{{cite journal |vauthors=Page DC |title=Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads |journal=Development |volume=101 Suppl |issue= |pages=151–5 |date=1987 |pmid=3503713 |doi= |url=}}</ref><ref name="pmid8533770">{{cite journal |vauthors=Tsuchiya K, Reijo R, Page DC, Disteche CM |title=Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome |journal=Am. J. Hum. Genet. |volume=57 |issue=6 |pages=1400–7 |date=December 1995 |pmid=8533770 |pmc=1801429 |doi= |url=}}</ref> | ||
The | * This tumor is called gonadoblastoma since it looks like [[embryonic]] tissue, but in an indifferent way regarding [[sexual development]]. | ||
* The association between GBY gene (GonadoBlastoma on [[Y chromosome]]) and gonadoblastoma was made in 1986. | |||
* In 1995, Tsuchiya found that the GBY gene located near the [[centromere]] of [[Y chromosome]] and contains multiple [[gene]]<nowiki/>s including testis-specific protein Y-encoded (TSPY) gene. | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Gonadoblastoma was first discovered by Dr. Scully in 1953. The association between GBY gene (GonadoBlastoma on the Y chromosome) and gonadoblastoma was made in 1986. In 1995, Tsuchiya found that the GBY gene located near the centromere of Y chromosome and contains multiple genes including Testis-specific protein Y-encoded (TSPY) gene.
Historical Perspective
- Gonadoblastoma was first discovered by Dr. Scully, an American pathologist, in 1953 studying the pathology of a series of tumors suspected of being dysgerminomas.[1][2][3][4]
- This tumor is called gonadoblastoma since it looks like embryonic tissue, but in an indifferent way regarding sexual development.
- The association between GBY gene (GonadoBlastoma on Y chromosome) and gonadoblastoma was made in 1986.
- In 1995, Tsuchiya found that the GBY gene located near the centromere of Y chromosome and contains multiple genes including testis-specific protein Y-encoded (TSPY) gene.
References
- ↑ Scully, Robert E. (1953). "Gonadoblastoma. A gonadal tumor related to the dysgerminoma (Seminoma) and capable of sex-hormone production". Cancer. 6 (3): 455–463. doi:10.1002/1097-0142(195305)6:3<455::AID-CNCR2820060303>3.0.CO;2-U. ISSN 0008-543X.
- ↑ Scully RE (1970). "Gonadoblastoma. A review of 74 cases". Cancer. 25 (6): 1340–56. PMID 4193741.
- ↑ Page DC (1987). "Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads". Development. 101 Suppl: 151–5. PMID 3503713.
- ↑ Tsuchiya K, Reijo R, Page DC, Disteche CM (December 1995). "Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome". Am. J. Hum. Genet. 57 (6): 1400–7. PMC 1801429. PMID 8533770.