Gonadoblastoma natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Gonadoblastoma per se is a benign tumor, however, it has the capacity to convert to [[dysgerminoma]] or other more malignant [[Germ cell tumor|germ cell tumors]] and produce steroids with resultant [[virilization]]. Prognosis is generally excellent after removing the tumor. | Gonadoblastoma per se is a [[benign tumor]], however, it has the capacity to convert to [[dysgerminoma]] or other more [[malignant]] [[Germ cell tumor|germ cell tumors]] and produce [[steroids]] with resultant [[virilization]]. [[Prognosis]] is generally excellent after removing the [[tumor]]. | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
* | *Gonadoblastoma usually develops in the first and second decades of life.<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref> | ||
*It is usually diagnosed during a workup for sex organ developmental disorders, primary amenorrhea and or virilization. | *If complicated by an [[invasive]] [[germ cell tumor]], then [[prognosis]] depends on the [[Staging (pathology)|staging]] of the [[tumor]].<ref name="978-0-323-40067-1">{{cite book | last = Saia | first = Philip | title = Clinical gynecologic oncology | publisher = Elsevier | location = Philadelphia, PA | year = 2018 | isbn = 978-0-323-40067-1 }}</ref> | ||
*It is usually diagnosed during a workup for [[sex organ]] developmental disorders, [[primary amenorrhea]], and/or [[virilization]]. | |||
===Complications=== | ===Complications=== | ||
*Common complications of gonadoblastoma include: | *Common [[complications]] of gonadoblastoma include:<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref> | ||
**Dysgerminoma | **[[Dysgerminoma]] | ||
**Seminoma | **[[Seminoma]] | ||
**Other gonadal malignancies | **Other gonadal [[malignancies]] | ||
===Prognosis=== | ===Prognosis=== | ||
*Prognosis is generally excellent if the tumor is removed | *[[Prognosis]] is generally excellent if the [[tumor]] is diagnosed and removed early.<ref name="urlPediatric Endocrinology | ScienceDirect">{{cite web |url=https://www.sciencedirect.com/book/9781455748587/pediatric-endocrinology |title=Pediatric Endocrinology | ScienceDirect |format= |work= |accessdate=}}</ref> | ||
*Depending on the presence of the coexisting germinal tumors at the time of diagnosis, the prognosis may vary. | *Depending on the presence of the coexisting germinal [[tumors]] at the time of [[diagnosis]], the [[prognosis]] may vary. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
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[[Category:Oncology]] | |||
[[Category:Gynecology]] | |||
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Latest revision as of 21:54, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Gonadoblastoma per se is a benign tumor, however, it has the capacity to convert to dysgerminoma or other more malignant germ cell tumors and produce steroids with resultant virilization. Prognosis is generally excellent after removing the tumor.
Natural History, Complications, and Prognosis
Natural History
- Gonadoblastoma usually develops in the first and second decades of life.[1]
- If complicated by an invasive germ cell tumor, then prognosis depends on the staging of the tumor.[2]
- It is usually diagnosed during a workup for sex organ developmental disorders, primary amenorrhea, and/or virilization.
Complications
- Common complications of gonadoblastoma include:[1]
- Dysgerminoma
- Seminoma
- Other gonadal malignancies
Prognosis
- Prognosis is generally excellent if the tumor is diagnosed and removed early.[3]
- Depending on the presence of the coexisting germinal tumors at the time of diagnosis, the prognosis may vary.
References
- ↑ 1.0 1.1 Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ Saia, Philip (2018). Clinical gynecologic oncology. Philadelphia, PA: Elsevier. ISBN 978-0-323-40067-1.
- ↑ "Pediatric Endocrinology | ScienceDirect".