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| __NOTOC__
| | #REDIRECT[[Hepatitis A virus]] |
| {{Hepatitis A}}
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| {{CMG}}; {{AE}} {{JS}}
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| ==Overview==
| | [[Category:Emergency mdicine]] |
| | | [[Category:Disease]] |
| ==Taxonomy==
| | [[Category:Up-To-Date]] |
| [[Viruses]]; ssRNA] [[viruses]]; [[Positive-sense ssRNA virus|ssRNA virus]]; positive-strand viruses; Picornavirales; [[Picornaviridae]]; [[Hepatovirus]]
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| ==Biology==
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| {| style="float: right;"
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| | [[File:HapatitisA.jpeg|200px|thumb|none|Electron micrograph of the Hepatitis A virus (HAV), an RNA virus that can survive up to a month at room temperature. <SMALL>Courtesy: ''[http://phil.cdc.gov/phil/home.asp Public Health Image Library (PHIL), Centers for Disease Control and Prevention (CDC)]''<ref>{{Cite web | title = http://phil.cdc.gov/phil/details.asp | url = http://phil.cdc.gov/phil/details.asp}}</ref></SMALL>]]
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| |}
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| [[Hepatitis A virus]] ([[HAV]]) is a 27 nm, [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]]. It is in length
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| ===Genome===
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| The [[HAV]] [[genome]] is encoded in 7474 [[nucleotides]], which are divided into three regions:
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| * 5' untranslated region, with 742 [[nucleotides]]
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| * Single reading frame encoding a 2227 [[amino acid]] [[polypeptide]], with 6681 [[nucleotides]]
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| * 3' noncoding region, with 63 [[nucleotides]]
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| The reading frame encodes a [[polypeptide]] that is processed by a [[viral]] [[protease]]. This process takes place cotranslationally, and leads to the formation of:
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| * Four structural proteins
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| * Seven nonstructural proteins
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| Four distinct genotypes of HAV have been identified in humans, although they do not appear to have important biological differences [3]. All four genotypes belong to a single serotype.
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| ==Tropism==
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| ==Natural Reservoir==
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| ==References==
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| {{Reflist|2}}
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| [[Category:Needs overview]] | |
| [[Category:Foodborne illnesses]] | |
| [[Category:hepatitis|A]] | |
| [[Category:Picornaviruses]]
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| [[Category:Viral diseases]]
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| [[Category:Mature chapter]]
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| [[Category:Infectious disease]] | | [[Category:Infectious disease]] |
| [[Category:Disease]] | | [[Category:Hepatology]] |
| | | [[Category:Gastroenterology]] |
| {{WH}}
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| {{WS}}
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