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| __NOTOC__
| | #REDIRECT[[Hepatitis B virus]] |
| {{Hepatitis B}}
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| {{CMG}}; {{AE}} {{JS}}
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| ==Overview==
| | [[Category:Emergency mdicine]] |
| The [[hepatitis B virus]] is an [[hepadnavirus]] with a DNA [[genome]]. The viral particle consists of an outer [[lipid]] envelope and an [[icosahedron|icosahedral]] [[nucleocapsid]] core composed of [[protein]]. The nucleocapsid encloses the viral DNA and a DNA [[polymerase]] that has [[reverse transcriptase]] activity. It shows [[tropism]] for [[hepatocytes]] and humans are its only [[natural reservoir]].
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| ==Taxonomy==
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| [[Viruses]]; Retro-transcribing viruses; [[Hepadnaviridae]]; Orthohepadnavirus
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| ==Biology==
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| {| style="float: right;"
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| | [[File:Hepatitis B virus.png|200px|thumb|none|Hepatitis B virions <SMALL>Courtesy: ''[http://www.who.int/en/ World Health Organization]''<ref>{{Cite web | title = http://www.who.int/en/ | url = http://www.who.int/en/}}</ref></SMALL>]]
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| | [[File:HBV Genome.png|200px|thumb|none|The genome organisation of HBV. The genes overlap. <SMALL>Courtesy: ''[Wikimedia Commons]''<ref>{{Cite web | title = http://commons.wikimedia.org/wiki/File:HBV_Genome.svg | url = http://commons.wikimedia.org/wiki/File:HBV_Genome.svg}}</ref></SMALL>]]
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| The [[hepatitis B virus]], an [[hepadnavirus]], is a 42 nm partially double stranded [[DNA]] virus, composed of a 27 nm nucleocapsid core (HBcAg), surrounded by an outer [[lipoprotein]] coat (also called envelope) containing the surface antigen ([[HBsAg]]).
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| [[Hepatocytes]] infected in vivo by [[hepadnaviruses]] produce an excess of noninfectious viral [[lipoprotein]] particles.
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| ==Tropism==
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| [[Hepatitis B virus]] shows [[tropism]] for [[hepatocytes]].<ref name=WHO>{{cite web | title = Hepatitis B | url = http://www.who.int/csr/disease/hepatitis/HepatitisB_whocdscsrlyo2002_2.pdf }}</ref>
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| ==Natural Reservoir==
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| The [[natural reservoir]] for [[hepatitis B virus]] is man. Closely related [[hepadnaviruses]] have been found in woodchucks and ducks, but they are not [[infectious]] for humans.<ref name=WHO1>{{cite web | title = Hepatitis B | url = http://www.who.int/csr/disease/hepatitis/whocdscsrlyo20022/en/index3.html }}</ref>
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| == References ==
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| {{Reflist|2}}
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| {{STD/STI}}
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| [[Category:Hepatitis|B]] | |
| [[Category:Viruses]] | |
| [[Category:Infectious disease]] | | [[Category:Infectious disease]] |
| | [[Category:Hepatology]] |
| [[Category:Gastroenterology]] | | [[Category:Gastroenterology]] |
| [[Category:Mature chapter]]
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| [[Category:Disease]]
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| {{WH}}
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| {{WS}}
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