Hepatitis E future or investigational therapies: Difference between revisions
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==Overview== | ==Overview== | ||
Attending to the impact of hepatitis E worldwide, further studies are required to [[diagnose]] and treat severe cases of the disease. Patients with elevated liver transaminases, particularly immunocompromised and end-stage liver disease | Attending to the impact of hepatitis E worldwide, further studies are required to [[diagnose]] and treat severe cases of the disease. [[Serological]] assays to identify past and current [[infections]] should be developed, in order to help in the accurate [[diagnosis]] of hepatitis E, in high-risk patients.<ref name="pmid22549046">{{cite journal| author=Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J et al.| title=Hepatitis E. | journal=Lancet | year= 2012 | volume= 379 | issue= 9835 | pages= 2477-88 | pmid=22549046 | doi=10.1016/S0140-6736(11)61849-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22549046 }} </ref><ref name="pmid22537448">{{cite journal| author=Wedemeyer H, Pischke S, Manns MP| title=Pathogenesis and treatment of hepatitis e virus infection. | journal=Gastroenterology | year= 2012 | volume= 142 | issue= 6 | pages= 1388-1397.e1 | pmid=22537448 | doi=10.1053/j.gastro.2012.02.014 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22537448 }} </ref> | ||
==Future or Investigational Therapies== | |||
Patients with elevated liver [[transaminases]], particularly [[immunocompromised]] and with end-stage [[liver disease]] should be tested for the presence of [[HEV]] [[RNA]]. Pregnant women with hepatitis E have an increased risk of [[complications]]. Therefore, when in the presence of elevated liver [[transaminases]], they should also be tested and treated.<ref name="pmid22549046">{{cite journal| author=Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J et al.| title=Hepatitis E. | journal=Lancet | year= 2012 | volume= 379 | issue= 9835 | pages= 2477-88 | pmid=22549046 | doi=10.1016/S0140-6736(11)61849-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22549046 }} </ref><ref name="pmid22537448">{{cite journal| author=Wedemeyer H, Pischke S, Manns MP| title=Pathogenesis and treatment of hepatitis e virus infection. | journal=Gastroenterology | year= 2012 | volume= 142 | issue= 6 | pages= 1388-1397.e1 | pmid=22537448 | doi=10.1053/j.gastro.2012.02.014 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22537448 }} </ref> | |||
Further studies are required to answer questions such as:<ref name="pmid22549046">{{cite journal| author=Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J et al.| title=Hepatitis E. | journal=Lancet | year= 2012 | volume= 379 | issue= 9835 | pages= 2477-88 | pmid=22549046 | doi=10.1016/S0140-6736(11)61849-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22549046 }} </ref><ref name="pmid22537448">{{cite journal| author=Wedemeyer H, Pischke S, Manns MP| title=Pathogenesis and treatment of hepatitis e virus infection. | journal=Gastroenterology | year= 2012 | volume= 142 | issue= 6 | pages= 1388-1397.e1 | pmid=22537448 | doi=10.1053/j.gastro.2012.02.014 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22537448 }} </ref> | |||
*What are the areas of [[endemic|hyperendemnicity]]? | |||
*Which [[serotype]]s prevail in different areas? | |||
*What is the real percentage of [[asymptomatic]] [[infection]]? | |||
*Other potential routes of [[infection]]? | |||
*What is the real risk of [[transmission]] of [[HEV]] through [[blood transfusion]]s? | |||
*What [[genotype]]s can cause chronic [[infection]]? | |||
*Mechanism of interaction between [[T-cell]]s and [[HEV]]? | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WS}} | |||
{{WH}} | |||
[[Category:Hepatitis|E]] | [[Category:Hepatitis|E]] | ||
[[Category:Viruses]] | [[Category:Viruses]] | ||
[[Category:Gastroenterology]] | |||
[[Category:Emergency mdicine]] | |||
[[Category:Disease]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
[[Category: | [[Category:Hepatology]] | ||
Latest revision as of 22:07, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Attending to the impact of hepatitis E worldwide, further studies are required to diagnose and treat severe cases of the disease. Serological assays to identify past and current infections should be developed, in order to help in the accurate diagnosis of hepatitis E, in high-risk patients.[1][2]
Future or Investigational Therapies
Patients with elevated liver transaminases, particularly immunocompromised and with end-stage liver disease should be tested for the presence of HEV RNA. Pregnant women with hepatitis E have an increased risk of complications. Therefore, when in the presence of elevated liver transaminases, they should also be tested and treated.[1][2]
Further studies are required to answer questions such as:[1][2]
- What are the areas of hyperendemnicity?
- Which serotypes prevail in different areas?
- What is the real percentage of asymptomatic infection?
- Other potential routes of infection?
- What is the real risk of transmission of HEV through blood transfusions?
- What genotypes can cause chronic infection?
- Mechanism of interaction between T-cells and HEV?
References
- ↑ 1.0 1.1 1.2 Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J; et al. (2012). "Hepatitis E." Lancet. 379 (9835): 2477–88. doi:10.1016/S0140-6736(11)61849-7. PMID 22549046.
- ↑ 2.0 2.1 2.2 Wedemeyer H, Pischke S, Manns MP (2012). "Pathogenesis and treatment of hepatitis e virus infection". Gastroenterology. 142 (6): 1388–1397.e1. doi:10.1053/j.gastro.2012.02.014. PMID 22537448.