HIV AIDS classification: Difference between revisions
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{{AIDS}} | {{AIDS}} | ||
{{CMG}} ; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Many definitions have been developed for [[epidemiology|epidemiological]] surveillance of HIV/AIDS such as the ''Bangui definition'' and the ''1994 Expanded World Health Organization AIDS Case Definition''. However, these systems are neither sensitive nor specific for clinical staging. In developing countries, the [[World Health Organization]] staging system for HIV infection and disease that uses clinical and laboratory data is widely employed. The [[Centers for Disease Control and Prevention|Centers for Disease Control]] (CDC) Classification System for HIV/AIDS is another primary system used that is primarily based on [[T helper cells|CD4 T-lymphocyte]] counts. | |||
==Classification== | ==Classification== | ||
=== WHO | ===WHO Staging System for HIV Infection and Disease in Adults and Adolescents<ref name=who>WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. 2006.</ref>=== | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width:950px " align=center | {| style="border: 0px; font-size: 90%; margin: 3px; width:950px " align=center | ||
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*Papular pruritic eruptions | *Papular pruritic eruptions | ||
*Angular cheilitis | *Angular cheilitis | ||
* | *Seborrhoeic [[dermatitis]] | ||
*Fungal [[finger nail]] [[infections]] | *Fungal [[finger nail]] [[infections]] | ||
|- | |- | ||
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|} | |} | ||
===WHO Staging System for HIV | ===WHO Staging System for HIV Infection and Disease in Children (Revised 2006) <ref name=who>WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. 2006.</ref>=== | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width:950px;" align=center | {| style="border: 0px; font-size: 90%; margin: 3px; width:950px;" align=center | ||
! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Clinical stage}} | ! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Clinical stage}} | ||
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*[[Hepatosplenomegaly]] | *[[Hepatosplenomegaly]] | ||
* | *Papular pruritic eruptions | ||
*[[Seborrhoeic dermatitis]] | *[[Seborrhoeic dermatitis]] | ||
*Extensive | *Extensive human papilloma virus infection | ||
*Extensive [[molluscum contagiosum]] | *Extensive [[molluscum contagiosum]] | ||
*Fungal | *Fungal nail [[infections]] | ||
*Recurrent [[oral ulcerations]] | *Recurrent [[oral ulcerations]] | ||
* | *Linear gingival erythema (LGE) | ||
*Angular [[cheilitis]] | *Angular [[cheilitis]] | ||
*[[Parotid]] enlargement | *[[Parotid]] enlargement | ||
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*Unexplained severe wasting or severe [[malnutrition]] not adequately responding to standard therapy | *Unexplained severe wasting or severe [[malnutrition]] not adequately responding to standard therapy | ||
*[[Pneumocystis pneumonia]] | *[[Pneumocystis pneumonia]] | ||
*Recurrent severe presumed bacterial [[infections]] (e.g. [[empyema]], [[pyomyositis]], [[bone]] or | *Recurrent severe presumed bacterial [[infections]] (e.g. [[empyema]], [[pyomyositis]], [[bone]] or joint infection, [[meningitis]], but excluding [[pneumonia]]) | ||
*Chronic [[herpes simplex]] infection; (orolabial or cutaneous of more than one month’s duration) | *Chronic [[herpes simplex]] infection; (orolabial or cutaneous of more than one month’s duration) | ||
*Extrapulmonary [[Tuberculosis]] | *Extrapulmonary [[Tuberculosis]] | ||
* | *Kaposi’s sarcoma | ||
*Oesophageal [[candidiasis]] | *Oesophageal [[candidiasis]] | ||
*Central nervous system [[toxoplasmosis]] (outside the neonatal period) | *Central nervous system [[toxoplasmosis]] (outside the neonatal period) | ||
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*[[Cryptosporidiosis]] | *[[Cryptosporidiosis]] | ||
*[[Isosporiasis]] | *[[Isosporiasis]] | ||
*Disseminated non-tuberculous | *Disseminated non-tuberculous mycobacteria infection | ||
*[[Candida]] of trachea, bronchi or lungs | *[[Candida]] of trachea, bronchi or lungs | ||
*Visceral | *Visceral herpes simplex infection | ||
*Acquired [[HIV]] associated rectal fistula | *Acquired [[HIV]] associated rectal fistula | ||
*Cerebral or B cell [[non-Hodgkin lymphoma]] | *Cerebral or B cell [[non-Hodgkin lymphoma]] | ||
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==CDC Classification System== | |||
{{ | The table below shows the HIV infection stage, based on age-specific CD4+ T-lymphocyte count or CD4+ T-lymphocyte percentage of total lymphocytes. <ref> {{cite web| url=http://www.cdc.gov/hiv/statistics/recommendations/terms.html| title=CDC HIV/AIDS Surveillance Publications}}</ref> | ||
{{#widget:BlueTable}} | |||
{|class="BlueTable" style="width: 500px" | |||
!rowspan=3|Stage* | |||
!colspan=6|Age on date of CD4 T-lymphocyte test | |||
|- | |||
! colspan=2|<1 year | |||
! colspan=2|1—5 years | |||
! colspan=2|6 years through adult | |||
|- | |||
! Cells/µL||%||Cells/µL||%||Cells/µL||% | |||
|- | |- | ||
| | | 1||≥1,500||≥34||≥1,000||≥30||≥500||≥26 | ||
| | |||
| | |||
|- | |- | ||
| | | 2||750—1,499||26—33||500—999||22—29||200—499||14—25 | ||
| | |||
| | |||
|- | |- | ||
| | | 3||<750||<26||<500||<22||<200||<14 | ||
| | |||
|- | |- | ||
|colspan=7|<small> *The stage is based primarily on the CD4+ T-lymphocyte count; the CD4+ T-lymphocyte count takes precedence over the CD4 T-lymphocyte percentage, and the percentage is considered only if the count is missing.</small> | |||
|} | |} | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category:HIV/AIDS]] | [[Category:HIV/AIDS]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Immune system disorders]] | [[Category:Immune system disorders]] | ||
[[Category: | [[Category:Viral diseases]] | ||
[[Category:Pandemics]] | [[Category:Pandemics]] | ||
[[Category:Sexually transmitted infections]] | [[Category:Sexually transmitted infections]] | ||
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[[Category:Immunodeficiency]] | [[Category:Immunodeficiency]] | ||
[[Category:Microbiology]] | [[Category:Microbiology]] | ||
[[Category:Emergency mdicine]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] |
Latest revision as of 22:11, 29 July 2020
AIDS Microchapters |
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HIV AIDS classification On the Web |
American Roentgen Ray Society Images of HIV AIDS classification |
Risk calculators and risk factors for HIV AIDS classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Many definitions have been developed for epidemiological surveillance of HIV/AIDS such as the Bangui definition and the 1994 Expanded World Health Organization AIDS Case Definition. However, these systems are neither sensitive nor specific for clinical staging. In developing countries, the World Health Organization staging system for HIV infection and disease that uses clinical and laboratory data is widely employed. The Centers for Disease Control (CDC) Classification System for HIV/AIDS is another primary system used that is primarily based on CD4 T-lymphocyte counts.
Classification
WHO Staging System for HIV Infection and Disease in Adults and Adolescents[1]
Clinical stage | Features |
---|---|
Clinical stage 1 |
|
Clinical stage 2 |
|
Clinical stage 3 |
Conditions where a presumptive diagnosis can be made on the basis of clinical signs or simple investigations
Conditions where confirmatory diagnostic testing is necessary
|
Clinical stage 4 |
Conditions where a presumptive diagnosis can be made on the basis of clinical signs or simple investigations
Conditions where confirmatory diagnostic testing is necessary
|
WHO Staging System for HIV Infection and Disease in Children (Revised 2006) [1]
Clinical stage | Features |
---|---|
Clinical stage 1 |
|
Clinical stage 2 |
|
Clinical stage 3 |
Conditions where a presumptive diagnosis can be made on the basis of clinical signs or simple investigations
Conditions where confirmatory diagnostic testing is necessary
|
Clinical stage 4 |
Conditions where a presumptive diagnosis can be made on the basis of clinical signs or simple investigations
Conditions where confirmatory diagnostic testing is necessary
|
CDC Classification System
The table below shows the HIV infection stage, based on age-specific CD4+ T-lymphocyte count or CD4+ T-lymphocyte percentage of total lymphocytes. [2]
Stage* | Age on date of CD4 T-lymphocyte test | |||||
---|---|---|---|---|---|---|
<1 year | 1—5 years | 6 years through adult | ||||
Cells/µL | % | Cells/µL | % | Cells/µL | % | |
1 | ≥1,500 | ≥34 | ≥1,000 | ≥30 | ≥500 | ≥26 |
2 | 750—1,499 | 26—33 | 500—999 | 22—29 | 200—499 | 14—25 |
3 | <750 | <26 | <500 | <22 | <200 | <14 |
*The stage is based primarily on the CD4+ T-lymphocyte count; the CD4+ T-lymphocyte count takes precedence over the CD4 T-lymphocyte percentage, and the percentage is considered only if the count is missing. |
References
- ↑ 1.0 1.1 WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. 2006.
- ↑ "CDC HIV/AIDS Surveillance Publications".