Lactose intolerance other diagnostic studies: Difference between revisions
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{{Lactose intolerance}} | {{Lactose intolerance}} | ||
{{CMG}}; {{AE}} {{MA}} | |||
==Overview== | |||
Lactose tolerance test may be helpful in the diagnosis of lactose intolerance. Findings suggestive of lactose intolerance include [[bloating]], [[diarrhea]] and [[abdominal pain]] and rising of blood [[glucose]] by less than 20 mg/dL after the ingestion of [[lactose]]. Genetic test can also be used for diagnosis of primary lactase deficiency that is associated with CC [[genotype]] at -13.9 kb upstream of the [[lactase]] gene. | |||
==Other Diagnostic Studies== | |||
Other diagnostic studies for lactose intolerance include: | |||
*Lactose tolerance test<ref name="pmid20686460">{{cite journal |vauthors=Law D, Conklin J, Pimentel M |title=Lactose intolerance and the role of the lactose breath test |journal=Am. J. Gastroenterol. |volume=105 |issue=8 |pages=1726–8 |year=2010 |pmid=20686460 |doi=10.1038/ajg.2010.146 |url=}}</ref> | |||
* Genetic test for primary lactase deficiency <ref name="pmid15479673">{{cite journal |vauthors=Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL |title=A genetic test which can be used to diagnose adult-type hypolactasia in children |journal=Gut |volume=53 |issue=11 |pages=1571–6 |year=2004 |pmid=15479673 |pmc=1774274 |doi=10.1136/gut.2004.040048 |url=}}</ref> | |||
===Lactose tolerance test=== | |||
*50 g of oral [[lactose]] in adults (2 g/kg in children) is administered and blood [[glucose]] levels are checked at 0, 60, and 120 minutes after the ingestion. | |||
**[[Symptom|Symptoms]] such as [[bloating]], [[diarrhea]] and [[abdominal pain]] and rising of blood [[glucose]] by less than 20 mg/dL (1.1 mmol/L) are diagnostic for lactose intolerance. | |||
**This test is used less than lactose breath hydrogen test because it needs repeated measurements of blood [[glucose]] level | |||
* False negative results cab be obtained due to | |||
** [[Diabetes]] | |||
** [[Small bowel bacterial overgrowth syndrome|Bacterial overgrowth]] | |||
===Genetic test for primary lactase deficiency=== | |||
* Acquired primary lactase deficiency is associated with a CC [[genotype]] at -13.9 kb upstream of the [[lactase]] gene and [[lactase]] persistence is related to TT [[genotype]].<ref name="pmid15479673">{{cite journal |vauthors=Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL |title=A genetic test which can be used to diagnose adult-type hypolactasia in children |journal=Gut |volume=53 |issue=11 |pages=1571–6 |year=2004 |pmid=15479673 |pmc=1774274 |doi=10.1136/gut.2004.040048 |url=}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | |||
{{WH}} | |||
{{WS}} | |||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category: | [[Category:Medicine]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
Latest revision as of 22:28, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
Lactose tolerance test may be helpful in the diagnosis of lactose intolerance. Findings suggestive of lactose intolerance include bloating, diarrhea and abdominal pain and rising of blood glucose by less than 20 mg/dL after the ingestion of lactose. Genetic test can also be used for diagnosis of primary lactase deficiency that is associated with CC genotype at -13.9 kb upstream of the lactase gene.
Other Diagnostic Studies
Other diagnostic studies for lactose intolerance include:
Lactose tolerance test
- 50 g of oral lactose in adults (2 g/kg in children) is administered and blood glucose levels are checked at 0, 60, and 120 minutes after the ingestion.
- False negative results cab be obtained due to
Genetic test for primary lactase deficiency
- Acquired primary lactase deficiency is associated with a CC genotype at -13.9 kb upstream of the lactase gene and lactase persistence is related to TT genotype.[2]
References
- ↑ Law D, Conklin J, Pimentel M (2010). "Lactose intolerance and the role of the lactose breath test". Am. J. Gastroenterol. 105 (8): 1726–8. doi:10.1038/ajg.2010.146. PMID 20686460.
- ↑ 2.0 2.1 Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL (2004). "A genetic test which can be used to diagnose adult-type hypolactasia in children". Gut. 53 (11): 1571–6. doi:10.1136/gut.2004.040048. PMC 1774274. PMID 15479673.