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| __NOTOC__ | | __NOTOC__ |
| {{Mucormycosis}} | | {{Mucormycosis}} |
| {{CMG}}; {{AE}}{{HK}} | | {{CMG}}; {{AE}} {{HK}} |
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| ==Overview== | | ==Overview== |
| When a clinician suspects invasive mucormycosis infection, an early diagnostic procedure performed within 16 days from the onset of symptom and early initiation of antifungal therapy will lead to successful management of this highly fatal disease.<ref name="pmid26565066">{{cite journal |vauthors=Jeong SJ, Lee JU, Song YG, Lee KH, Lee MJ |title=Delaying diagnostic procedure significantly increases mortality in patients with invasive mucormycosis |journal=Mycoses |volume=58 |issue=12 |pages=746–52 |year=2015 |pmid=26565066 |doi=10.1111/myc.12428 |url=}}</ref> Biopsy with H&E staining of the specimen and PCR may confirm the diagnosis in suspected cases.
| | There are no other diagnostic studies for mucormycosis. |
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| ==Key Findings on Hemotoxylin and Eosin (H&E) sections in Mucormycosis==<ref name="pmid10756000">{{cite journal |vauthors=Ribes JA, Vanover-Sams CL, Baker DJ |title=Zygomycetes in human disease |journal=Clin. Microbiol. Rev. |volume=13 |issue=2 |pages=236–301 |year=2000 |pmid=10756000 |pmc=100153 |doi= |url=}}</ref> | | ==Other Diagnostic Studies== |
| *Subcutaneous lesions showed aseptate hyphae immersed in an intense acute inflammatory exudate of neutrophils, eosinophils and fibrosis
| | There are no other diagnostic studies for mucormycosis. |
| *Focal collections of epithelioid and Langhans multinucleated giant cells were also observed
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| *Mucor spp. typically are rapid growing, producing globose sporangia on sporangiophores that are either solitary or branched
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| *The sporangia contain the entire columella and spores that are mucus bound.
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| *The sporangial wall collapses irregularly, if at all.
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| *Rhizoids and stolons are absent. These features distinguish the Mucor spp. from the other producers of globose sporangia
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| ==Key Findings on PCR analysis in Mucormycosis==
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| *Detection of fungal DNA from biopsy specimens allows rapid identification of the causative organism of mucormycosis<ref name="pmid16416267">{{cite journal |vauthors=Rickerts V, Just-Nübling G, Konrad F, Kern J, Lambrecht E, Böhme A, Jacobi V, Bialek R |title=Diagnosis of invasive aspergillosis and mucormycosis in immunocompromised patients by seminested PCR assay of tissue samples |journal=Eur. J. Clin. Microbiol. Infect. Dis. |volume=25 |issue=1 |pages=8–13 |year=2006 |pmid=16416267 |doi=10.1007/s10096-005-0078-7 |url=}}</ref>
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| *Mucorales quantitative PCR could not only confirm the mucormycosis diagnosis when other mycological arguments were present but could also anticipate this diagnosis<ref name="pmid26706615">{{cite journal |vauthors=Millon L, Herbrecht R, Grenouillet F, Morio F, Alanio A, Letscher-Bru V, Cassaing S, Chouaki T, Kauffmann-Lacroix C, Poirier P, Toubas D, Augereau O, Rocchi S, Garcia-Hermoso D, Bretagne S |title=Early diagnosis and monitoring of mucormycosis by detection of circulating DNA in serum: retrospective analysis of 44 cases collected through the French Surveillance Network of Invasive Fungal Infections (RESSIF) |journal=Clin. Microbiol. Infect. |volume=22 |issue=9 |pages=810.e1–810.e8 |year=2016 |pmid=26706615 |doi=10.1016/j.cmi.2015.12.006 |url=}}</ref>
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| *Quantification of DNA loads may also be a useful adjunct to treatment monitoring
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| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
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| {{WH}}
| | [[Category:Emergency mdicine]] |
| {{WS}}
| | [[Category:Disease]] |
| | [[Category:Up-To-Date]] |
| | [[Category:Infectious disease]] |
| | [[Category:Gastroenterology]] |
| | [[Category:Otolaryngology]] |
| | [[Category:Nephrology]] |
| | [[Category:Dermatology]] |
| | [[Category:Pulmonology]] |