Muscle weakness and Myoglobinuria: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{CMG}}; {{AE}} {{IQ}} | {{CMG}}; {{AE}} {{IQ}} | ||
==Differential Diagnosis of Muscle weakness and Myoglobinuria== | |||
{| | {| | ||
! rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Organ system | ! rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Organ system | ||
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! style="background:#4479BA; color: #FFFFFF;" align="center" + |Electromyogram | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Electromyogram | ||
|- | |- | ||
!Medication−induced | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Medication−induced | ||
! style="background:#DCDCDC;" align="center" + |[[Statins]]<ref name="pmid22001973">{{cite journal |vauthors=Tomaszewski M, Stępień KM, Tomaszewska J, Czuczwar SJ |title=Statin-induced myopathies |journal=Pharmacol Rep |volume=63 |issue=4 |pages=859–66 |date=2011 |pmid=22001973 |doi= |url=}}</ref> | ! style="background:#DCDCDC;" align="center" + |[[Statins]]<ref name="pmid22001973">{{cite journal |vauthors=Tomaszewski M, Stępień KM, Tomaszewska J, Czuczwar SJ |title=Statin-induced myopathies |journal=Pharmacol Rep |volume=63 |issue=4 |pages=859–66 |date=2011 |pmid=22001973 |doi= |url=}}</ref> | ||
| style="background:#F5F5F5;" align="center" + |60+ | | style="background:#F5F5F5;" align="center" + |60+ | ||
| Line 59: | Line 59: | ||
* Normal | * Normal | ||
|- | |- | ||
! rowspan="3" |Endocrine | ! rowspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" + |Endocrine | ||
! style="background:#DCDCDC;" align="center" + |[[Hyperaldosteronism]] with myopathy<ref name="pmid5037033">{{cite journal |vauthors=Sambrook MA, Heron JR, Aber GM |title=Myopathy in association with primary hyperaldosteronism |journal=J. Neurol. Neurosurg. Psychiatry |volume=35 |issue=2 |pages=202–7 |date=April 1972 |pmid=5037033 |pmc=494037 |doi= |url=}}</ref> | ! style="background:#DCDCDC;" align="center" + |[[Hyperaldosteronism]] with myopathy<ref name="pmid5037033">{{cite journal |vauthors=Sambrook MA, Heron JR, Aber GM |title=Myopathy in association with primary hyperaldosteronism |journal=J. Neurol. Neurosurg. Psychiatry |volume=35 |issue=2 |pages=202–7 |date=April 1972 |pmid=5037033 |pmc=494037 |doi= |url=}}</ref> | ||
| style="background:#F5F5F5;" align="center" + |50 | | style="background:#F5F5F5;" align="center" + |50 | ||
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* Normal | * Normal | ||
|- | |- | ||
!Infectious | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Infectious | ||
! style="background:#DCDCDC;" align="center" + |[[Influenza]]<ref name="pmid6687269">{{cite journal |vauthors=Bove KE, Hilton PK, Partin J, Farrell MK |title=Morphology of acute myopathy associated with influenza B infection |journal=Pediatr Pathol |volume=1 |issue=1 |pages=51–66 |date=1983 |pmid=6687269 |doi= |url=}}</ref> | ! style="background:#DCDCDC;" align="center" + |[[Influenza]]<ref name="pmid6687269">{{cite journal |vauthors=Bove KE, Hilton PK, Partin J, Farrell MK |title=Morphology of acute myopathy associated with influenza B infection |journal=Pediatr Pathol |volume=1 |issue=1 |pages=51–66 |date=1983 |pmid=6687269 |doi= |url=}}</ref> | ||
| style="background:#F5F5F5;" align="center" + |Variable | | style="background:#F5F5F5;" align="center" + |Variable | ||
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* N/A | * N/A | ||
|} | |} | ||
==References== | |||
{{Reflist|2}} | |||
[[Category:Medicine]] | |||
[[Category:Neurology]] | |||
[[Category:Rheumatology]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 22:48, 29 July 2020
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Differential Diagnosis of Muscle weakness and Myoglobinuria
| Organ system | Disease | Symptoms | History | Physical
Examination |
Diagnosis | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age of onset | Muscle weakness | Fever | Myalgia | Contractures | Gait abnormality | Neuropathy | Atrophy | Stiffness | Myoglobinuria | Other features | Laboratory Findings | Creatine Kinase | Muscle Biopsy | Electromyogram | |||||
| Medication−induced | Statins[1] | 60+ | Proximal | − | + | − | − | − | − | − | −/+(Rhabdomyolysis) |
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| Endocrine | Hyperaldosteronism with myopathy[2] | 50 | Proximal & distal |
− | − | − | − | − | − | − | + |
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| Hyperthyroidism[3] | 40 | Proximal | − | − | − | − | − | + | + | + |
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| Hypothyroidism[4] | 55 | Proximal | − | + | + | − | − | + | + | + Rhabdomyolysis |
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| Infectious | Influenza[5] | Variable | Proximal and Distal | + | + | − | + | − | − | − | + |
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References
- ↑ Tomaszewski M, Stępień KM, Tomaszewska J, Czuczwar SJ (2011). "Statin-induced myopathies". Pharmacol Rep. 63 (4): 859–66. PMID 22001973.
- ↑ Sambrook MA, Heron JR, Aber GM (April 1972). "Myopathy in association with primary hyperaldosteronism". J. Neurol. Neurosurg. Psychiatry. 35 (2): 202–7. PMC 494037. PMID 5037033.
- ↑ Li Q, Liu Y, Zhang Q, Tian H, Li J, Li S (July 2017). "Myopathy in hyperthyroidism as a consequence of rapid reduction of thyroid hormone: A case report". Medicine (Baltimore). 96 (30): e7591. doi:10.1097/MD.0000000000007591. PMC 5627834. PMID 28746208.
- ↑ Khaleeli AA, Griffith DG, Edwards RH (September 1983). "The clinical presentation of hypothyroid myopathy and its relationship to abnormalities in structure and function of skeletal muscle". Clin. Endocrinol. (Oxf). 19 (3): 365–76. PMID 6627693.
- ↑ Bove KE, Hilton PK, Partin J, Farrell MK (1983). "Morphology of acute myopathy associated with influenza B infection". Pediatr Pathol. 1 (1): 51–66. PMID 6687269.