Nephrotic syndrome biopsy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Nephrotic syndrome}} | {{Nephrotic syndrome}} | ||
{{CMG}}; {{AE}} [[User:YazanDaaboul|Yazan Daaboul]], [[User:Sergekorjian|Serge Korjian]], {{MJ}} | |||
==Overview== | |||
[[Ultrasound]]-guided renal biopsy for visualization under [[light microscopy]], [[immunofluorescence]] or immunoperoxidase, and [[electron microscopy]] is usually recommended for patients with nephrotic syndrome.<ref name="pmid18497417">{{cite journal| author=Hull RP, Goldsmith DJ| title=Nephrotic syndrome in adults. | journal=BMJ | year= 2008 | volume= 336 | issue= 7654 | pages= 1185-9 | pmid=18497417 | doi=10.1136/bmj.39576.709711.80 | pmc=PMC2394708 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18497417 }} </ref> Renal biopsy provides diagnostic and prognostic benefit. However, guidelines that define the timing and the circumstances to perform renal [[biopsy]] are not present. In [[minimal change disease]], the most common primary cause of nephrotic syndrome in children, and in [[diabetic nephropathy]], the most common secondary cause of nephrotic syndrome in adults, renal biopsy is not generally recommended and is not routinely performed.<ref name="pmid19904897">{{cite journal| author=Kodner C| title=Nephrotic syndrome in adults: diagnosis and management. | journal=Am Fam Physician | year= 2009 | volume= 80 | issue= 10 | pages= 1129-34 | pmid=19904897 | doi= | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19904897 }} </ref> Nonetheless, patients who present with unknown or unsure etiology of nephrotic syndrome are recommended to undergo renal biopsy for definitive diagnosis.<ref name="pmid19904897">{{cite journal| author=Kodner C| title=Nephrotic syndrome in adults: diagnosis and management. | journal=Am Fam Physician | year= 2009 | volume= 80 | issue= 10 | pages= 1129-34 | pmid=19904897 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19904897 }} </ref>{{Nephrotic syndrome}} | |||
== Biopsy == | |||
== | *Kidney biopsy is the gold standard test for the diagnosis of nephrotic syndrome.<ref name="pmid3341661">{{cite journal |vauthors= |title=Clinical competence in percutaneous renal biopsy. Health and Public Policy Committee. American College of Physicians |journal=Ann. Intern. Med. |volume=108 |issue=2 |pages=301–3 |date=February 1988 |pmid=3341661 |doi= |url=}}</ref> | ||
*This method will reveal the exact cause of [[proteinuria]]. | |||
'''Relative contrandications of the kidney biopsy:''' | |||
*Single kidney, | |||
*Anatomic kidney abnormalities, | |||
*Small size [[kidneys]] (less than 9 cm), indicative of [[end stage renal disease]] | |||
*Renal tumor | |||
*Multiple, bilateral cysts | |||
*Active infection in the kidney or on the skin over the biopsy side | |||
*Uncorrectable [[bleeding diathesis]] | |||
*Severe uncontrolled [[hypertension]] | |||
*[[Hydronephrosis]] | |||
*Uncooperative patient | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WS}} | |||
[[Category:Needs content]] | [[Category:Needs content]] | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Syndromes]] | [[Category:Syndromes]] | ||
Latest revision as of 22:57, 29 July 2020
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Nephrotic Syndrome Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Nephrotic syndrome biopsy On the Web |
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American Roentgen Ray Society Images of Nephrotic syndrome biopsy |
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Risk calculators and risk factors for Nephrotic syndrome biopsy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, Serge Korjian, Mehrian Jafarizade, M.D [2]
Overview
Ultrasound-guided renal biopsy for visualization under light microscopy, immunofluorescence or immunoperoxidase, and electron microscopy is usually recommended for patients with nephrotic syndrome.[1] Renal biopsy provides diagnostic and prognostic benefit. However, guidelines that define the timing and the circumstances to perform renal biopsy are not present. In minimal change disease, the most common primary cause of nephrotic syndrome in children, and in diabetic nephropathy, the most common secondary cause of nephrotic syndrome in adults, renal biopsy is not generally recommended and is not routinely performed.[2] Nonetheless, patients who present with unknown or unsure etiology of nephrotic syndrome are recommended to undergo renal biopsy for definitive diagnosis.[2]
|
Nephrotic Syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Nephrotic syndrome biopsy On the Web |
|
American Roentgen Ray Society Images of Nephrotic syndrome biopsy |
|
Risk calculators and risk factors for Nephrotic syndrome biopsy |
Biopsy
- Kidney biopsy is the gold standard test for the diagnosis of nephrotic syndrome.[3]
- This method will reveal the exact cause of proteinuria.
Relative contrandications of the kidney biopsy:
- Single kidney,
- Anatomic kidney abnormalities,
- Small size kidneys (less than 9 cm), indicative of end stage renal disease
- Renal tumor
- Multiple, bilateral cysts
- Active infection in the kidney or on the skin over the biopsy side
- Uncorrectable bleeding diathesis
- Severe uncontrolled hypertension
- Hydronephrosis
- Uncooperative patient
References
- ↑ Hull RP, Goldsmith DJ (2008). "Nephrotic syndrome in adults". BMJ. 336 (7654): 1185–9. doi:10.1136/bmj.39576.709711.80. PMC 2394708. PMID 18497417.
- ↑ 2.0 2.1 Kodner C (2009). "Nephrotic syndrome in adults: diagnosis and management". Am Fam Physician. 80 (10): 1129–34. PMID 19904897.
- ↑ "Clinical competence in percutaneous renal biopsy. Health and Public Policy Committee. American College of Physicians". Ann. Intern. Med. 108 (2): 301–3. February 1988. PMID 3341661.