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__NOTOC__
__NOTOC__
{{Non small cell lung cancer}}
{{Non small cell lung cancer}}
{{CMG}}; {{AE}} {{SC}}
{{CMG}}; {{AE}} {{SC}} {{MV}}
==Overview==
==Overview==
Non-small cell lung cancer may be classified according to the WHO histological classification system into 3 main types: squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Other less common subtypes, include: adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumors of lung, and carcinomas of the lung of salivary gland type.<ref name="NSCLC"> Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.</ref>
Non-small cell lung cancer may be classified according to the [[World Health Organization|WHO histological classification system]] into 3 main types; [[Squamous cell lung cancer|Squamous cell carcinoma]], [[Adenocarcinoma of the lung|lung adenocarcinoma]], and [[Large cell carcinoma of the lung|large cell carcinoma]]. Other less common subtypes include adenosquamous lung carcinoma, [[Sarcomatoid carcinoma of the lung|pulmonary sarcomatoid carcinoma]], [[carcinoid tumor of the lung]], and carcinomas of the lung of salivary gland type.
 
==Classification==
==Classification==
* There are 3 main types of non–small cell lung cancer: adenocarcinoma, squamous cell carcinoma and large cell carcinoma.
* There are 3 main types of non–small cell lung cancer:<ref name="NSCLC">Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.</ref><ref>{{cite book | last = Travis | first = William | title = Pathology and genetics of tumours of the lung, pleura, thymus, and heart | publisher = IARC Press | location = Lyon | year = 2004 | isbn = 9283224183 }}</ref><ref name="pmid16640802">{{cite journal| author=Raz DJ, He B, Rosell R, Jablons DM| title=Bronchioloalveolar carcinoma: a review. | journal=Clin Lung Cancer | year= 2006 | volume= 7 | issue= 5 | pages= 313-22 | pmid=16640802 | doi=10.3816/CLC.2006.n.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16640802  }} </ref>
*The table below summarizes the WHO histological classification system for non small cell lung cancer.<ref>{{cite book | last = Travis | first = William | title = Pathology and genetics of tumours of the lung, pleura, thymus, and heart | publisher = IARC Press | location = Lyon | year = 2004 | isbn = 9283224183 }}</ref><ref name="pmid16640802">{{cite journal| author=Raz DJ, He B, Rosell R, Jablons DM| title=Bronchioloalveolar carcinoma: a review. | journal=Clin Lung Cancer | year= 2006 | volume= 7 | issue= 5 | pages= 313-22 | pmid=16640802 | doi=10.3816/CLC.2006.n.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16640802  }} </ref>
** [[Adenocarcinoma of the lung|Adenocarcinoma]]
** [[Squamous cell carcinoma of the lung|Squamous cell carcinoma]]
** [[Large cell carcinoma of the lung|Large cell carcinoma]]
*The table below summarizes the WHO histological classification system for non small cell lung cancer.<ref name="radiowiki">  Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016 </ref>


{| class="wikitable"
{|
|+
! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" + |WHO histological classification system<br>Adapted from WHO/IARC (2006)
! colspan="3" style="text-align: center; font-weight: bold; width: 1000px" | WHO histological classification system
|-
|-
| style="text-align: center; font-weight: bold;" | Main types
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Main types
| style="text-align: center; font-weight: bold;" | Subtypes
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subtypes
| style="text-align: center; font-weight: bold;" | Prevalence
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Prevalence
|-
|-
| Adenocarcinoma
! align="center" style="background:#DCDCDC;" + |Adenocarcinoma
|  
| align="left" style="background:#F5F5F5;" + |
*Adenocarcinoma, mixed
*Adenocarcinoma, mixed
*Acinar adenocarcinoma         
*Acinar adenocarcinoma         
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*Signet ring adenocarcinoma             
*Signet ring adenocarcinoma             
*Clear cell adenocarcinoma
*Clear cell adenocarcinoma
| 40% of lung cancers
| align="center" style="background:#F5F5F5;" + |
*40% of lung cancers
|-
|-
| Squamous cell carcinoma
! align="center" style="background:#DCDCDC;" + |Squamous cell carcinoma
|  
| align="left" style="background:#F5F5F5;" + |
*Papillary         
*Papillary         
*Clear cell         
*Clear cell         
*Small cell  
*Small cell  
*Basaloid
*Basaloid
| 25% of lung cancers
| align="left" style="background:#F5F5F5;" + |
*25% of lung cancers
|-
|-
| Large cell carcinoma
! align="center" style="background:#DCDCDC;" + |Large cell carcinoma
|  
| align="left" style="background:#F5F5F5;" + |
*Large cell neuroendocrine carcinoma  
*Large cell neuroendocrine carcinoma  
*Basaloid carcinoma  
*Basaloid carcinoma  
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*Clear cell carcinoma
*Clear cell carcinoma
*Large cell carcinoma with rhabdoid phenotype
*Large cell carcinoma with rhabdoid phenotype
| 10% of lung cancer
| align="left" style="background:#F5F5F5;" + |
*10% of lung cancer
|-
|-
| style="font-weight: bold;" | Less common types
| colspan="3" style="background: #4479BA; width: 100px; text-align:center;" |{{fontcolor|#FFF|'''Less common types'''}}
|
|
|-
|-
| Adenosquamous carcinoma
! align="center" style="background:#DCDCDC;" + |Adenosquamous carcinoma
|
| align="left" style="background:#F5F5F5;" + |
*No subtypes
*No subtypes
| Less than 5%
| align="left" style="background:#F5F5F5;" + |
*Less than 5%
|-
|-
| Sarcomatoid carcinoma
! align="center" style="background:#DCDCDC;" + |Sarcomatoid carcinoma
|  
| align="left" style="background:#F5F5F5;" + |
*Pleomorphic carcinoma  
*Pleomorphic carcinoma  
*Spindle cell carcinoma  
*Spindle cell carcinoma  
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*Carcinosarcoma         
*Carcinosarcoma         
*Pulmonary blastoma
*Pulmonary blastoma
| Less than 5%
| align="left" style="background:#F5F5F5;" + |
*Less than 5%
|-
|-
| Carcinoid tumor
! align="center" style="background:#DCDCDC;" + |Carcinoid tumor
|  
| align="left" style="background:#F5F5F5;" + |
*Typical carcinoid         
*Typical carcinoid         
*Atypical carcinoid
*Atypical carcinoid
| Less than 5%
| align="left" style="background:#F5F5F5;" + |
*Less than 5%
|-
|-
| Salivary gland tumor
! align="center" style="background:#DCDCDC;" + |Salivary gland tumor
|  
| align="left" style="background:#F5F5F5;" + |
*Mucoepidermoid carcinoma         
*Mucoepidermoid carcinoma         
*Adenoid cystic carcinoma  
*Adenoid cystic carcinoma  
*Epithelial-myoepithelial carcinoma
*Epithelial-myoepithelial carcinoma
| Less than 5%
| align="left" style="background:#F5F5F5;" + |
*Less than 5%
|}
|}


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{{reflist|2}}
{{reflist|2}}


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Latest revision as of 22:58, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Non-small cell lung cancer may be classified according to the WHO histological classification system into 3 main types; Squamous cell carcinoma, lung adenocarcinoma, and large cell carcinoma. Other less common subtypes include adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumor of the lung, and carcinomas of the lung of salivary gland type.

Classification

WHO histological classification system
Adapted from WHO/IARC (2006)
Main types Subtypes Prevalence
Adenocarcinoma
  • Adenocarcinoma, mixed
  • Acinar adenocarcinoma
  • Papillary adenocarcinoma
  • Bronchioloalveolar carcinoma
  • Nonmucinous
  • Mucinous
  • Mixed nonmucinous and mucinous or indeterminate
  • Solid adenocarcinoma with mucin production
  • Fetal adenocarcinoma
  • Mucinous (“colloid”) carcinoma
  • Mucinous cystadenocarcinoma
  • Signet ring adenocarcinoma
  • Clear cell adenocarcinoma
  • 40% of lung cancers
Squamous cell carcinoma
  • Papillary
  • Clear cell
  • Small cell
  • Basaloid
  • 25% of lung cancers
Large cell carcinoma
  • Large cell neuroendocrine carcinoma
  • Basaloid carcinoma
  • Lymphoepithelioma-like carcinoma
  • Clear cell carcinoma
  • Large cell carcinoma with rhabdoid phenotype
  • 10% of lung cancer
Less common types
Adenosquamous carcinoma
  • No subtypes
  • Less than 5%
Sarcomatoid carcinoma
  • Pleomorphic carcinoma
  • Spindle cell carcinoma
  • Giant cell carcinoma
  • Carcinosarcoma
  • Pulmonary blastoma
  • Less than 5%
Carcinoid tumor
  • Typical carcinoid
  • Atypical carcinoid
  • Less than 5%
Salivary gland tumor
  • Mucoepidermoid carcinoma
  • Adenoid cystic carcinoma
  • Epithelial-myoepithelial carcinoma
  • Less than 5%

References

  1. ↑ Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.
  2. ↑ Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.
  3. ↑ Raz DJ, He B, Rosell R, Jablons DM (2006). "Bronchioloalveolar carcinoma: a review". Clin Lung Cancer. 7 (5): 313–22. doi:10.3816/CLC.2006.n.012. PMID 16640802.
  4. ↑ Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016
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