Polycystic kidney disease history and symptoms: Difference between revisions

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{{Polycystic kidney disease}}
{{Polycystic kidney disease}}
{{CMG}} {{AE}} [[User:Sergekorjian|Serge Korjian]],[[User:YazanDaaboul|Yazan Daaboul]]
{{CMG}}; {{AE}}{{MKA}}, [[User:Sergekorjian|Serge Korjian]],[[User:YazanDaaboul|Yazan Daaboul]]


==Overview==
==Overview==
Common clues for ADPKD on history include flank or back pain, nocturia and polyuria, headache and family history of renal failure or diagnosed renal cystic diseases.
The hallmark of polycystic kidney disease is [[flank]] or [[back]] [[pain]]. A positive family history of [[renal failure]], [[cystic]] [[diseases]], intracranial [[aneurysms]] is suggestive of polycystic kidney disease. The most common symptoms of polycystic kidney disease include [[hematuria]], [[polyuria]], [[nocturia]] and [[hypertension]].


==History==
==History and Symptoms==
''Early ADPKD is asymptomatic and clinical diagnosis is usually with family history and imaging. Common symptoms at presentation include:''<ref name="pmid8321262">{{cite journal| author=Gabow PA| title=Autosomal dominant polycystic kidney disease. | journal=N Engl J Med | year= 1993 | volume= 329 | issue= 5 | pages= 332-42 | pmid=8321262 | doi=10.1056/NEJM199307293290508 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8321262 }} </ref><ref name="pmid17434405">{{cite journal| author=Torres VE, Harris PC, Pirson Y| title=Autosomal dominant polycystic kidney disease. | journal=Lancet | year= 2007 | volume= 369 | issue= 9569 | pages= 1287-301 | pmid=17434405 | doi=10.1016/S0140-6736(07)60601-1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17434405 }} </ref>
*The hallmark of polycystic kidney disease is [[flank]] or [[back]] [[pain]]. A positive family history of [[renal failure]], [[cystic]] diseases, [[intracranial aneurysms]] is suggestive of polycystic kidney disease.  
* '''Flank/Back pain''' due to an enlarging cyst, cyst infection or hemorrhage, nephrolithiasis, and pyelonephritis.
*The most common symptoms of polycystic kidney disease include [[hematuria]], [[polyuria]], [[nocturia]] and [[hypertension]].
* '''Headache''' due to hypertension
* '''Polyuria and nocturia''' due to loss of concentrating ability
* '''Hematuria'''
* '''Dyspnea, early satiety, and obstructive jaundice''' due to enlarging hepatic cysts
<br>
''Other important clues on history include:''
* Detailed family history of renal failure and cystic diseases
* Detailed family history of intracranial aneurysms and aneurysmal rupture to assess patient risk


==History and Symptoms==
*The majority of patients with [disease name] are asymptomatic.
OR
*The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
*Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. 
===History===
===History===
Patients with [disease name]] may have a positive history of:
Patients with polycystic kidney disease may have a positive history of:<ref name="pmid8321262">{{cite journal| author=Gabow PA| title=Autosomal dominant polycystic kidney disease. | journal=N Engl J Med | year= 1993 | volume= 329 | issue= 5 | pages= 332-42 | pmid=8321262 | doi=10.1056/NEJM199307293290508 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8321262 }} </ref>
*[History finding 1]
*[[Fatigue]]/[[weakness]]/[[malaise]]
*[History finding 2]
*[[Blood]] in [[urine]]
*[History finding 3]
*[[Flank]]/[[back]] [[pain]]
*[[Headache]] from [[hypertension]]
*Family history of [[renal failure]] or diagnosed [[renal]] [[cystic]] diseases
*Family history of intracranial or abdominal [[aortic]] [[aneurysms]]


===Common Symptoms===
===Common Symptoms===
Common symptoms of [disease] include:
Common symptoms of polycystic kidney disease include:<ref name="pmid17434405">{{cite journal| author=Torres VE, Harris PC, Pirson Y| title=Autosomal dominant polycystic kidney disease. | journal=Lancet | year= 2007 | volume= 369 | issue= 9569 | pages= 1287-301 | pmid=17434405 | doi=10.1016/S0140-6736(07)60601-1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17434405 }} </ref>
*[Symptom 1]
*[[Flank]]/[[back]] [[pain]]
*[Symptom 2]
*[[Hematuria]]
*[Symptom 3]
*[[Hypertension]]
*[[Polyuria]]
*[[Nocturia]]


===Less Common Symptoms===
===Less Common Symptoms===
Less common symptoms of [disease name] include
Less common symptoms of polycystic kidney disease include:<ref name="pmid26413277">{{cite journal |vauthors=Baker A, King D, Marsh J, Makin A, Carr A, Davis C, Kirby C |title=Understanding the physical and emotional impact of early-stage ADPKD: experiences and perspectives of patients and physicians |journal=Clin Kidney J |volume=8 |issue=5 |pages=531–7 |date=October 2015 |pmid=26413277 |pmc=4581379 |doi=10.1093/ckj/sfv060 |url=}}</ref>
*[Symptom 1]
*[[Dyspnea]]
*[Symptom 2]
*Early [[satiety]]
*[Symptom 3]
*[[Jaundice]]
*[[Urinary tract infection]]
*[[Pyelonephritis]]
*[[Nephrolithiasis]]


==References==
==References==
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[[Category:Up-To-Date]]
[[Category:Medicine]]
[[Category:Nephrology]]

Latest revision as of 23:46, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2], Serge Korjian,Yazan Daaboul

Overview

The hallmark of polycystic kidney disease is flank or back pain. A positive family history of renal failure, cystic diseases, intracranial aneurysms is suggestive of polycystic kidney disease. The most common symptoms of polycystic kidney disease include hematuria, polyuria, nocturia and hypertension.

History and Symptoms

History

Patients with polycystic kidney disease may have a positive history of:[1]

Common Symptoms

Common symptoms of polycystic kidney disease include:[2]

Less Common Symptoms

Less common symptoms of polycystic kidney disease include:[3]

References

  1. Gabow PA (1993). "Autosomal dominant polycystic kidney disease". N Engl J Med. 329 (5): 332–42. doi:10.1056/NEJM199307293290508. PMID 8321262.
  2. Torres VE, Harris PC, Pirson Y (2007). "Autosomal dominant polycystic kidney disease". Lancet. 369 (9569): 1287–301. doi:10.1016/S0140-6736(07)60601-1. PMID 17434405.
  3. Baker A, King D, Marsh J, Makin A, Carr A, Davis C, Kirby C (October 2015). "Understanding the physical and emotional impact of early-stage ADPKD: experiences and perspectives of patients and physicians". Clin Kidney J. 8 (5): 531–7. doi:10.1093/ckj/sfv060. PMC 4581379. PMID 26413277.

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